国家自然科学基金(China)

作品数：220被引量：1229H指数：16
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Angiogenic signaling pathways and anti-angiogenic therapy for cancer被引量：36
《Signal Transduction and Targeted Therapy》2023年第6期2599-2637,共39页Zhen-Ling Liu Huan-Huan Chen Li-Li Zheng Li-Ping Sun Lei Shi 
supported by the National Natural Science Foundation of China(21102182);the Natural Science Foundation of Jiangsu Province(BK2012760,China);Fundamental Research Funds for the Central Universities(2632018ZD09,China);Excellent Science and Technology Innovation Team of Jiangsu Province Universities in 2015(China).
Angiogenesis,the formation of new blood vessels,is a complex and dynamic process regulated by various pro-and anti-angiogenic molecules,which plays a crucial role in tumor growth,invasion,and metastasis.With the advan...
关键词：INVASION DRUGS METASTASIS 
The dichotomous role of immunoproteasome in cancer:Friend or foe?被引量：3
《Acta Pharmaceutica Sinica B》2023年第5期1976-1989,共14页Boya Chen Haiying Zhu Bo Yang Ji Cao 
grants from National Natural Science Foundation of China(No.81930102 to Bo Yang);Zhejiang Provincial Natural Science Foundation(No.LR22H310002 to Ji Cao,China);Zhejiang University K.P.Chao's High Technology Development Foundation(China)。
Immunoproteasome is a variant of proteasome with structural differences in 20S subunits optimizing them for the production of antigenic peptides with higher binding affinity to major histocompatibility complex(MHC)-I ...
关键词：IMMUNOPROTEASOME Ubiquitin—proteasome system Antigenic peptides PROTEOLYSIS CANCER Immunotherapy Proteasome inhibitor Targeted therapy 
UHRF1/DNMT1—MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer被引量：1
《Acta Pharmaceutica Sinica B》2023年第5期2086-2106,共21页Shuye Lin Hanli Xu Lin Qin Mengdi Pang Ziyu Wang Meng Gu Lishu Zhang Cong Zhao Xuefeng Hao Zhiyun Zhang Weimin Ding Jianke Ren Jiaqiang Huang 
National Natural Science Foundation of China(NSFC grant No.32200462,China);National Natural Science Foundation of China(NSFC grant No.81872021,China);Beijing Municipal Administration of Hospitals Youth Program(grant No.QMS20221603,China);R&D Program of Beijing Municipal Education Commission(grant No.KM202110025004,China);Beijing Natural Science Foundation of China(BJSFC No.7214242,China);Beijing Municipal Administration of Hospitals Incubating Program(grant No.PX2021063,China);Intramural Research Funding Program from Beijing Tuberculosis and Thoracic Tumor Research Institute/Beijing Chest Hospital。
As confusion mounts over RNA isoforms involved in phenotypic plasticity,aberrant CpG methylation-mediated disruption of alternative splicing is increasingly recognized as a driver of intratumor heterogeneity(ITH).Prot...
关键词：Lung cancer Intratumor heterogeneity Splice variants Intragenic CpG methylation Protease serine 3 Myeloid zinc finger 1 UHRF1/DNMT1 5-AZA-CDR 
Enhancement of oligodendrocyte autophagy alleviates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion in rats被引量：2
《Acta Pharmaceutica Sinica B》2023年第5期2107-2123,共17页Huiyang Wang Yueyang Liu Zhenkun Guo Minghui Cui Peng Pang Jingyu Yang Chunfu Wu 
the Natural Science Foundation of Liaoning Province(LJKQZ2021031,2022-MS-246,China)to Yueyang Liu。
Cognitive impairment caused by chronic cerebral hypoperfusion(CCH)is associated with white matter injury(WMI),possibly through the alteration of autophagy.Here,the autophagy—lysosomal pathway(ALP)dysfunction in white...
关键词：Chronic cerebral hypoperfusion Two vessel occlusion White matter Cognitive impairment OLIGODENDROCYTE Myelin sheath Autophagy-lysosomal pathway Mechanistic target of rapamycin 
Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome被引量：5
《Acta Pharmaceutica Sinica B》2023年第5期2176-2187,共12页Chuan Hu Yujun Song Yiwei Zhang Siqin He Xueying Liu Xiaotong Yang Tao Gong Yuan Huang Huile Gao 
the National Natural Science Foundation of China(82173762,China);111 Project(B18035,China);the Fundamental of Research Funds for the Central Universities(China);the Key Research and Development Program of Science and Technology Department of Sichuan Province(2022JDJQ0050,China);Project of Chengdu Science and Technology Bureau(2020-GH03-00003-HZ)。
Intelligent responsive drug delivery system opens up new avenues for realizing safer and more effective combination immunotherapy.Herein,a kind of tumor cascade-targeted responsive liposome(NLG919@Lip-pep1)is develope...
关键词：Immunotherapy Cascade targeting LIPOSOME MMP-2 responsive Breast cancer ICBs IDO inhibitors Immunosuppressive microenvironment 
Data-driven engineering framework with AI algorithm of Ginkgo Folium tablets manufacturing被引量：2
《Acta Pharmaceutica Sinica B》2023年第5期2188-2201,共14页Lijuan Ma Jing Zhang Ling Lin Tuanjie Wang Chaofu Ma Xiaomeng Wang Mingshuang Li Yanjiang Qiao Yongxiang Wang Guimin Zhang Zhisheng Wu 
co-National Outstanding Youth Science Fund Project of National Natural Science Foundation of China(Grant No.82022073,China);Major scientific and technological R&D projects in Jiangxi Province(Grant No.20203ABC28W018,China);National Key Research and Development Program of China(Grant No.2018YFC1706900,China)。
Smart manufacturing still remains critical challenges for pharmaceutical manufacturing.Here,an original data-driven engineering framework was proposed to tackle the challenges.Firstly,from sporadic indicators to five ...
关键词：Smart manufacturing Data-driven engineering Artificial intelligence Information fusion Process capability index End-to-end Quality traceability Real-world Ginkgo Folium products 
Click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries被引量：8
《Acta Pharmaceutica Sinica B》2023年第5期2202-2218,共17页Huitong Ruan Yongfang Li Cheng Wang Yixu Jiang Yulong Han Yiwei Li Dandan Zheng Jing Ye Gang Chen Guo-yuan Yang Lianfu Deng Ming Guo Xingcai Zhang Yaohui Tang Wenguo Cui 
support from Harvard/MIT;support by grants from the National Key R&D Program of China(2019YFA0112000);National Natural Science Foundation of China(Nos.81930051,82003658,81801170);the Interdisciplinary Program of Shanghai Jiao Tong University(ZH2018ZDA04,China);Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20171906,China);China Postdoctoral Science Foundation(2019M661546);National Postdoctoral Program for Innovative Talents(BX20200212,China);Zhejiang Provincial Natural Science Foundation of China(No.LQ21H300009,China)。
Central nervous system(CNS)injuries,including stroke,traumatic brain injury,and spinal cord injury,are essential causes of death and long-term disability and are difficult to cure,mainly due to the limited neuron rege...
关键词：Central nervous system injuries Stroke Neural stem cell Neurogenesis Click chemistry Extracellular vesicles Microglia Targeted delivery 
Recent progress of aptamer-drug conjugates in cancer therapy被引量：8
《Acta Pharmaceutica Sinica B》2023年第4期1358-1370,共13页Jiaxuan He Qiao Duan Chunyan Ran Ting Fu Yuan Liu Weihong Tan 
supported by the Zhejiang Provincial Natural Science Foundation of China(No.Y21C050001,China);Zhejiang Provincial Research Center for Diagnosis and Treatment of Major Diseases(No.JBZX-202003,China);the National Natural Science Foundation of China(Nos.22104132 and 22204144);the Zhejiang Province“Kunpeng”Program;。
Aptamers are single-stranded DNA or RNA sequences that can specifically bind with the target protein or molecule via specific secondary structures.Compared to antibody-drug conjugates(ADC),aptamer-drug conjugate(ApDC)...
关键词：APTAMER Cancer therapy Aptamer-drug conjugate Drug delivery Small-molecule drug Therapeutic molecules Nucleic acid drugs Biotherapeutic drug 
The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer被引量：2
《Acta Pharmaceutica Sinica B》2023年第4期1438-1466,共29页Yang Liu Wei Xu Mingxue Li Yueying Yang Dejuan Sun Lidian Chen Hua Li Lixia Chen 
supported by National Natural Science Foundation of China(NSFC)(No.81773637,82141216,U1803122);Chunhui Program-Cooperative Research Project of the Ministry of Education;Shenyang Young and Middle-aged Innovative Talents Support Program(RC210446,China);Liaoning Province Natural Science Foundation(Nos.2022-MS-241,2020-MZLH-31,China);support from National-Local Joint Engineering Research Center for Molecular Biotechnology of Fujian&Taiwan TCM,Fujian Key Laboratory of Chinese Materia Medica,Fujian University Key Laboratory for Research and Development of TCM Resources,at Fujian University of Traditional Chinese Medicine。
Reprogramming of energy metabolism is one of the basic characteristics of cancer and has been proved to be an important cancer treatment strategy.Isocitrate dehydrogenases(IDHs)are a class of key proteins in energy me...
关键词：IDH1 CANCER Regulatory mechanisms IDH1 inhibitors D-2HG Metabolic reprogramming EPIGENETICS Immune microenvironment 
Recent advances in diverse nanosystems for nitric oxide delivery in cancer therapy被引量：2
《Acta Pharmaceutica Sinica B》2023年第4期1498-1521,共24页Dan Gao Sajid Asghar Rongfeng Hu Su Chen Ruixin Niu Jia Liu Zhipeng Chen Yanyu Xiao 
supported by the Foundation of Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application(No.2021KFKT04,China);the National Natural Science Foundation of China(No.81973488,China);College Students Innovation Project for the R&D of Novel Drugs(No.J1310032,China)。
Gas therapy has been proven to be a promising and advantageous treatment option for cancers.Studies have shown that nitric oxide(NO)is one of the smallest structurally significant gas molecules with great potential to...
关键词：Nitric oxide Nitric oxide donor Nitric oxide-based delivery system ANTI-CANCER Binding mechanisms Synergistic treatment strategy Inorganic platforms Organic platforms 
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