IMMUNOPROTEASOME

作品数：8被引量：13H指数：3
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The role of proteasomes in tumorigenesis被引量：2
《Genes & Diseases》2024年第4期155-169,共15页Xiangyi Zhou Ruqing Xu Yue Wu Li Zhou Tingxiu Xiang 
supported by the National Natural Science Foundation of China(No.82172619);the Natural Science Foundation of Chongqing,China(No.CSTC2021jscx-gksb-No023);the Medical and Industrial Integration Project(China)(No.2022CDJYGRH-002).
Protein homeostasis is the basis of normal life activities,and the proteasomefamily plays an extremely important function in this process.The proteasome 2os is a concentric circle structure with twoαrings and twoβri...
关键词：BORTEZOMIB Cancer therapy IMMUNOPROTEASOME MULTIPLEMYELOMA Proteasome 20S Proteasome inhibitor Thymoproteasom 
A novel role of PSMB9 in endothelial cells and atherosclerosis: beyond its canonical function in immunoproteasome
《Acta Pharmacologica Sinica》2024年第7期1530-1532,共3页Xiaolei Liu Esteban Delgado 
The ubiquitin-proteasome system (UPS) constitutes a highly conserved protein degradation system in eukaryotic cells [1], comprising ubiquitin, ubiquitin enzymes, the 26 S proteasome, and deubiquitinating enzymes. The ...
关键词：PROTEASOME ATHEROSCLEROSIS BEYOND 
The dichotomous role of immunoproteasome in cancer:Friend or foe?被引量：3
《Acta Pharmaceutica Sinica B》2023年第5期1976-1989,共14页Boya Chen Haiying Zhu Bo Yang Ji Cao 
grants from National Natural Science Foundation of China(No.81930102 to Bo Yang);Zhejiang Provincial Natural Science Foundation(No.LR22H310002 to Ji Cao,China);Zhejiang University K.P.Chao's High Technology Development Foundation(China)。
Immunoproteasome is a variant of proteasome with structural differences in 20S subunits optimizing them for the production of antigenic peptides with higher binding affinity to major histocompatibility complex(MHC)-I ...
关键词：IMMUNOPROTEASOME Ubiquitin—proteasome system Antigenic peptides PROTEOLYSIS CANCER Immunotherapy Proteasome inhibitor Targeted therapy 
Inhibition of the immunoproteasome LMP_(2) ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway被引量：3
《Military Medical Research》2022年第4期404-418,共15页Xing-Yong Chen Shao-Fen Wan Nan-Nan Yao Ze-Jing Lin Yan-Guang Mao Xiao-Hua Yu Yin-Zhou Wang 
supported by the National Natural Science Foundation of China(81771250);the Natural Science Foundation of Fujian Province,China(2020J011059,2020R1011004);the Joint Funds for the Innovation of Science and Technology of Fujian Province,China(2017Y9065);the High-level hospital foster grants from Fujian Provincial Hospital,Fujian Province,China(2020HSJJ07)。
Background:Disruption of the blood–brain barrier(BBB)after a stroke can lead to brain injury and neurological impairment.Previous work confirmed the involvement of the immunoproteasome subunit of low molecular mass p...
关键词：IMMUNOPROTEASOME Blood–brain barrier Wnt/β-catenin pathway Oxygen–glucose deprivation/reperfusion Cerebral ischemia 
Proteasomal adaptations to FDA-approved proteasome inhibitors:a potential mechanism for drug resistance?
《Cancer Drug Resistance》2021年第3期634-645,共12页Kyung Bo Kim 
National Institutes of Health(R01 CA188354).
With proteasome inhibitors(PIs)becoming clinically available since 2003,outcomes for patients with multiple myeloma(MM)have dramatically changed,improving quality of life and survival.Despite the impressive treatment ...
关键词：Constitutive proteasome IMMUNOPROTEASOME carfilzomib BORTEZOMIB drug resistance 
Association between plasma immunoproteasome and 90-day prognosis after first-ever ischemic stroke被引量：6
《Neural Regeneration Research》2021年第4期795-800,共6页Xing-Yong Chen Ming Fu Shao-Fen Wan Xu Zhang Yin-Zhou Wang 
This work was supported by the National Natural Science Foundation of China,No.81771250(to XYC);the Natural Science Foundation of Fujian Province of China,Nos.2013J01275(to XYC),2016J01432(to XYC),2018J01255(to XZ);Young and Middle-aged Talents Training Project of Health and Family Planning Committee of Fujian Province,China,No.2015-ZQN-JC-5(to XYC);Joint Funds for the Innovation of Science and Technology of Fujian Province,China,No.2017Y9065(to XYC);High-Level Hospital Foster Grants from Fujian Provincial Hospital,Fujian Province,China,No.2020HSJJ07(to XYC).
Many blood biomarkers are reportedly helpful for predicting post-stroke cognitive impairment(PSCI),but no biomarkers are widely used in clinical practice.The purpose of this study was to investigate the association be...
关键词：behavior BIOMARKER brain clinical trial cognitive impairment immune function neurological function protein stroke 
Dopaminergic neurons show increased low-molecular-mass protein 7 activity induced by 6-hydroxydopamine in vitro and in vivo
《Translational Neurodegeneration》2018年第1期175-186,共12页Ming-Shu Mo Gui-Hua Li Cong-Cong Sun Shu-Xuan Huang Lei Wei Li-Min Zhang Miao-Miao Zhou Zhuo-Hua Wu Wen-Yuan Guo Xin-Ling Yang Chao-Jun Chen Shao-Gang Qu Jian-Xing He Ping-Yi Xu 
This work was supported by research grants from National Key R&D Program of China(2016YFC1306600,SQ2017YFSF110116);National Natural Science Foundation of China(81701254,81471292,U1603281,U1503222,81430021,81501100,NO.8187050204);Science Foundation of Guangdong of China(2015A030311021,2018A030313649);a technology project of Guangzhou(201504281820463);Shandong Provincial Natural Science Foundation(BS2015YY041);International Project of Science and Technology for Guangdong(2016A050502025);Science and Technology of Guangdong of China(2013B022000026);Collaborative Innovation Foundation of Guangzhou Science and Technology Bureau(2018-1202-SF-0019).
Background:Abnormal expression of major histocompatibility complex class I(MHC-I)is increased in dopaminergic(DA)neurons in the substantia nigra(SN)in Parkinson’s disease(PD).Low-molecular-mass protein 7(β5i)is a pr...
关键词：Parkinson’s disease 6-HYDROXYDOPAMINE IMMUNOPROTEASOME TAP1 
Mallory-Denk body pathogenesis revisited
《World Journal of Hepatology》2010年第8期295-301,共7页Samuel W French Fawzia Bardag-Gorce Barbara A French Joan Oliva 
Supported by the NIH/NIAAA 8116;Alcohol Center Grant on Liver and Pancreas P50-011999,Morphology Core
This editorial reviews the recent evidence showing that Mallory-Denk bodies(MDBs)form in hepatocytes as the result of a drug-induced shift from the 26s proteasome formation to the immunoproteasome formation.The shift ...
关键词：TOLL-LIKE receptor PROINFLAMMATORY Methyl DONORS EPIGENETIC processes Drug toxicity 26s PROTEASOME IMMUNOPROTEASOME 
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