《Biomedical and Environmental Sciences》

作品数:3340被引量:10859H指数:31
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《Biomedical and Environmental Sciences》
主办单位:中国疾病预防控制中心
最新期次:2025年4期更多>>
发文主题:IN_CHINARATSASSOCIATIONAMONGEFFECTS更多>>
发文领域:医药卫生生物学环境科学与工程农业科学更多>>
发文基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划北京市自然科学基金更多>>
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Identification of High-Risk Populations: The Cornerstone of Effective and Cost-Efficient Cancer Screening
《Biomedical and Environmental Sciences》2025年第4期401-402,共2页Wei Cao Fei Wang Ni Li 
Cancer screening is a strategy focused on highrisk populations rather than universal populationwide screening, based on a comprehensive evaluation of epidemiological principles and practical feasibility. The effective...
关键词:epidemiological principles practical feasibility cancer screening screening technology sensitivity high risk populations disease prevalence practical feasibility epidemiological principles 
Role of Gold Nanorods Functionalized by Nucleic Acid Nanostructures Carrying Doxorubicin in Synergistic Anti-Cancer Therapy
《Biomedical and Environmental Sciences》2025年第4期403-415,共13页Hao Wu Huangshui Ma Xinghan Wu Qiang Sun Lin Feng Ruifang Jiang Yanhong Li Quan Shi 
supported by the PLAGH Innovation Funds,(Grant No.22QNFC080);the Sichuan Science and Technology Program(Grant No.2023ZYD0064 and 2023YFG0220);the Fundamental Research Funds for the Central Universities(Grant No.YJ202242);the Research Funding from West China School/Hospital of Stomatology, Sichuan University(Grant No.QDJF2022-2);National Undergraduate Training Program for Innovation(Grant No.C2024129736)。
Objective Cancer remains a significant global health challenge, necessitating the development of effective treatment approaches. Developing synergistic therapy can provide a highly promising strategy for anti-cancer t...
关键词:Gold Nanorods Synergistic therapy NANOMATERIALS Anti-tumor therapy 
Construction of a Prognostic Model for Lysosome-dependent Cell Death in Gastric Cancer Based on Single-cell RNA-seq and Bulk RNA-seq Data
《Biomedical and Environmental Sciences》2025年第4期416-432,共17页Peng Ni Kaixin Guo Tianyi Liang Xinshuang Fan Yanqiao Hua Yangye Gao Shuaiyin Chen Guangcai Duan Rongguang Zhang 
supported by Hainan Provincial Natural Science Foundation of China(No.820CXTD438);National Natural Science Foundation of China(No.82160634, No.81773495)。
Objective To identify prognostic genes associated with lysosome-dependent cell death(LDCD)in patients with gastric cancer(GC).Methods Differentially expressed genes(DEGs)were identified using The Cancer Genome Atlas-S...
关键词:Gastric cancer Lysosomal dependent cell death Single-cell analysis Risk model Immune infiltration 
Threshold-Effect Associations of Serum 25- hydroxyvitamin D on Bone Turnover Markers and GC rs2282679 Variants in Chinese Women of Childbearing Age
《Biomedical and Environmental Sciences》2025年第4期433-446,共14页Xiaoyun Shan Yuting Li Xiayu Zhao Yichun Hu Siran Li Huidi Zhang Yang Cao Rui Wang Lichen Yang 
Objective This study aimed to investigate possible serum 25-hydroxyvitamin D[25(OH)D]cutoffs for the associations between 25(OH)D and Bone turnover markers(BTMs),and how GC gene variation influences such cutoffs in Ch...
关键词:25-hydroxyvitamin D OSTEOCALCIN Procollagen type 1 N-terminal propeptide β-CrossLaps of type 1 collagen containing cross-linked C-telopeptide Gene polymorphism 
Exploring the Efficacy of BMSC Transplantation via Various Pathways for Treating Cholestatic Liver Fibrosis in Mice
《Biomedical and Environmental Sciences》2025年第4期447-458,共12页Junjie Ren Zixu Li Xinrui Shi Tingting Lyu Xiaonan Li Min Ge Qizhi Shuai Tingjuan Huang 
supported by grants from the Natural Science Research Project of Shanxi Basic Research Program [20210302123246];the Scientific Research Project of Shanxi Provincial Health Commission [2020079];the Natural Science Foundation Youth Fund of Hebei Province[C2022402032];the Shanxi Province Higher Education “Billion Project” Science and Technology Guidance Project [BYJL036]。
Objective To compare the therapeutic efficacy of portal and tail vein transplantation of bone marrowderived mesenchymal stem cells(BMSCs) against cholestatic liver fibrosis in mice.Methods BMSCs were isolated and co-c...
关键词:Bone marrow mesenchymal stem cells Portal vein Tail vein Cholestatic hepatic fibrosis Administration route 
Homocysteine Levels and Determinants among Chinese Women at Mid-pregnancy, Late Pregnancy, and Postpartum
《Biomedical and Environmental Sciences》2025年第4期459-468,共10页Zhenyu Guo Hongtian Li Yirui Ma Ying Meng Yubo Zhou Jianmeng Liu 
Objective Data on homocysteine(Hcy) status and its determinants are limited among women during pregnancy and postpartum. This cross-sectional study aimed to investigate Hcy levels during pregnancy and postpartum, and ...
关键词:HOMOCYSTEINE HYPERHOMOCYSTEINEMIA Pregnancy and postpartum Determinants 
Antibiotic-Depleted Lung Microbiota Modulates Surfactant Proteins Expression and Reduces Experimental Silicosis
《Biomedical and Environmental Sciences》2025年第4期469-483,共15页Qiang Zhou Meiyu Chang Ning Li Yi Guan Sanqiao Yao 
supported by the National Natural Science Foundation of China Joint Fund for Regional Innovation and Development(Grant numbers [U21A20334]);the Postgraduate Innovation Funding Project of Hebei Province(Grant numbers [CXZZBS2022116])。
Objective Recent studies have overturned the traditional concept of the lung as a “sterile organ” revealing that pulmonary microbiota dysbiosis and abnormal surfactant proteins(SPs) expression are involved in the pr...
关键词:16s rRNA sequencing FIBROSIS Lung microbiota ANTIBIOTICS Surfactant proteins 
Hydrogen Sulfide Alleviates Lipid Peroxidation-Mediated Carbonyl Stress in Uranium-Intoxicated Kidney Cells via Nrf2/ARE Signaling
《Biomedical and Environmental Sciences》2025年第4期484-500,共17页Jialin Liu Min Wang Rui Zhang Jifang Zheng Xixiu Jiang Qiaoni Hu 
supported by the National Natural Science Foundation of China(No.82160627);the Natural Science Foundation of the Guangxi Autonomous Region(No.2020GXNFSAA297262)。
Objective To explore the protective effects and underlying mechanisms of H_2S against lipid peroxidation-mediated carbonyl stress in the uranium-treated NRK-52E cells.Methods Cell viability was evaluated using CCK-8 a...
关键词:Hydrogen sulfide(H_2S) Carbonyl stress Lipid peroxidation URANIUM NEPHROTOXICITY NRF2 
Development and Validation of Machine Learning Models for Lung Cancer Risk Prediction in High-Risk Population: A Retrospective Cohort Study
《Biomedical and Environmental Sciences》2025年第4期501-505,共5页Yu Su Haoran Zhan Shangyao Li Yitong Lu Ruhuan Ma Hai Fang Tingting Xu Yu Tian 
supported by the National Natural Science Foundation of China(grant numbers 82204127 and 72204172)。
Lung cancer, the leading cause of cancer deaths worldwide and in China, has a 19.7% five-year survival rate due to terminal-stage diagnosis^([1-3]).Although low-dose computed tomography(CT) screening can reduce mortal...
关键词:lung cancer retrospective cohort study lung cancer risk prediction low dose computed tomography high risk population MORTALITY machine learning false positive rates 
Risk Factors and Predictive Model for Acute Mountain Sickness among Han Chinese Travelers to Xizang Autonomous Region
《Biomedical and Environmental Sciences》2025年第4期506-510,共5页Qianhui Gong Qiong Li Zhichao Xu Xiaowei Chen Xiaobing Shen 
Acute mountain sickness(AMS) is an illness caused by hypoxia due to rapid ascent to altitudes above 2,500 m. Symptoms include headache,nausea, vomiting, and loss of appetite, all of which usually improve within 1 to 2...
关键词:risk factors Han Chinese travelers ALTITUDE HYPOXIA acute mountain sickness ams Xizang Autonomous Region SYMPTOMS acute mountain sickness 
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