《Chinese Journal of Natural Medicines》

作品数：2679被引量：15555H指数：43
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《Chinese Journal of Natural Medicines》
主办单位：中国药科大学;中国药学会
最新期次：2025年4期更多>>
发文主题：英文化学成分天然药物中药NEW更多>>
发文领域：医药卫生生物学化学工程文化科学更多>>
发文作者：梁敬钰余伯阳孔令义李萍王峥涛更多>>
发文机构：中国药科大学中国科学院中国医学科学院北京协和医学院第二军医大学更多>>
发文基金：国家自然科学基金国家高技术研究发展计划国家重点基础研究发展计划中国博士后科学基金更多>>
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Xiaohuang Qudan decoction alleviates ANIT-induced cholestatic liver injury by inhibiting the JAK2/STAT3 pathway and regulating TH17/Treg
《Chinese Journal of Natural Medicines》2025年第4期457-470,共14页Zhangkui Tan Lifeng Chen Zhiqin Ye Qiping Lu 
supported by the Natural Science Foundation of Hubei Province(No.2022CFD020);the Postdoctoral Research Initiation Fund(No.20211015KY19);the Hubei Provincial Medical Young Top Talents[No.2019(48)]。
Xiaohuang Qudan decoction(XHQDD)is a classical traditional Chinese medicine(TCM)formula widely used in the treatment of cholestatic liver injury.Despite its widespread use,the protective mechanism of XHQDD against cho...
关键词：ANIT TH17/TREG Cholestatic liver injury Xiaohuang Qudan decoction JAK2/STAT3 UHPLC-MS/MS 
Shionone protects cerebral ischemic injury through alleviating microglia-mediated neuroinflammation
《Chinese Journal of Natural Medicines》2025年第4期471-479,共9页Lushan Xu Chenggang Li ChenChen Zhao Zibu Wang Zhi Zhang Xin Shu Xiang Cao Shengnan Xia Xinyu Bao Pengfei Shao Yun Xu 
supported by the National Natural Science Foundation of China(Nos.81920108017 and 82130036);the Key Research and Development Program of Jiangsu Province of China(No.BE2020620);Jiangsu Province Key Medical Discipline(No.ZDXKA2016020)。
Microglia,the resident immune cells in the central nervous system(CNS),rapidly transition from a resting to an active state in the acute phase of ischemic brain injury.This active state mediates a pro-inflammatory res...
关键词：Shionone Ischemic Stroke NEUROINFLAMMATION Microglial Activation AKT-mTOR-STAT3 Signaling Pathway 
Andrographolide sulfonate alleviates rheumatoid arthritis by inhibiting glycolysis-mediated activation of PI3K/AKT to restrain Th17 cell differentiation
《Chinese Journal of Natural Medicines》2025年第4期480-491,共12页Chunhong Jiang Xi Zeng Jia Wang Xiaoqian Wu Lijuan Song Ling Yang Ze Li Ning Xie Xiaomei Yuan Zhifeng Wei Yi Guan 
supported by the project of Central Funds Guiding the Local Science and Technology Development(No.20212ZDD02010)。
Andrographolide sulfonate(AS)is a sulfonated derivative of andrographolide extracted from Andrographis paniculata(Burm.f.)Nees,and has been approved for several decades in China.The present study aimed to investigate ...
关键词：Andrographolide sulfonate Rheumatoid arthritis Th17 cell differentiation GLYCOLYSIS PI3K/AKT pathway 
Novel araucarene diterpenes from Agathis dammara exert hypoglycemic activity by promoting pancreatic β cell regeneration and glucose uptake
《Chinese Journal of Natural Medicines》2025年第4期492-503,共12页Zhewei Yu Yi Zhang Wenhui Wang XinYi Wu Shunzhi Liu Yanlin Bin Hongsheng Li Bangping Cai Zheng Wang Meijuan Fang Rong Qi Mingyu Li Yingkun Qiu 
supported by the Traditional Chinese Medicine Foundation of Xiamen City,China(No.XWZY-2023-0303);the Natural Science Foundation of Xiamen City,China(No.3502Z20227162)。
In this study,araucarene diterpenes,characterized by a pimarene skeleton with a variably oxidized side chain at C-13,were investigated.A total of 16 araucarene diterpenoids and their derivatives were isolated from the...
关键词：Agathis dammara Araucarene DITERPENES HYPOGLYCEMIC Pancreatic β Cells 
Structurally diverse sesquiterpenoids with anti-MDR cancer activity from Penicillium roqueforti
《Chinese Journal of Natural Medicines》2025年第4期504-512,共9页Shuyuan Mo Nanjin Ding Zhihong Huang Jun Yao Weiguang Sun Jianping Wang Yonghui Zhang Zhengxi Hu 
supported by the National Natural Science Foundation of China(Nos.82273811,32470417,and U22A20380);the National Program for Support of Top-notch Young Professionals(No.0106514050);the Hubei Provincial Natural Science Foundationof China(No.2024AFA028);the National Key R&D Program of China(No.2021YFA0910500);the Science and Technology Major Project of Hubei Province(Nos.2021ACA012 and 2024BCB021);the Chinese Medicine Research Foundation of the Health Commission of Hubei Province(No.ZY2025Z013)。
Five novel nor-eremophilane-type sesquiterpenoids,peniroqueforins E–H and J(1–4 and 7),two new eremophilane-type sesquiterpenoids,peniroqueforins I and K(5 and 8),and a new eudesmane-type sesquiterpenoid,peniroquefo...
关键词：Penicillium roqueforti SESQUITERPENOIDS Nor-sesquiterpenoids Anti-MDR cancer activity 
Pure drug nanomedicines-where we are?
《Chinese Journal of Natural Medicines》2025年第4期385-409,共25页Yaoyao Lai Bing Xie Wanting Zhang Wei He 
supported by the National Natural Science Foundation of China(Nos.82073782 and 82241002)。
Pure drug nanomedicines(PDNs)encompass active pharmaceutical ingredients(APIs),including macromolecules,biological compounds,and functional components.They overcome research barriers and conversion thresholds associat...
关键词：Pure drug nanomedicines Drug nanocrystals Drug-drug cocrystals Antibody-drug conjugates Drug nanoparticles Nanobodies 
Mass spectral database-based methodologies for the annotation and discovery of natural products
《Chinese Journal of Natural Medicines》2025年第4期410-420,共11页Fengyao Yang Zeyuan Liang Haoran Zhao Jiayi Zheng Lifang Liu Huipeng Song Guizhong Xin 
supported by the National Natural Science Foundation of China(Nos.82274064,82374026,and 82204591)。
Natural products(NPs)have long held a significant position in various fields such as medicine,food,agriculture,and materials.The chemical space covered by NPs is extensive but often underexplored.Therefore,high-throug...
关键词：Mass spectrometry Natural products ANNOTATION DATABASES 
Total alkaloids from Thesium chinense inhibit lipopolysaccharide-induced respiratory inflammation by modulating Nrf2/NF-κB/NLRP3 signaling pathway
《Chinese Journal of Natural Medicines》2025年第4期421-430,共10页Guohui Li Yueqin Guan Lintao Xu Guangcheng Peng Qingtong Han Tian Wang Zhenpeng Xu Xuesen Wen Hongxiang Lou Tao Shen 
supported by the National Natural Science Foundation of China(No.82274065);Toxicology of Traditional Chinese Medicines,a High-Level Priority Subject in Chinese Medicine in National Administration of Traditional Chinese Medicine(No.ZYYZDXK-2023296);Cutting Edge Development Fund of Advanced Medical Research Institute(No.GYY2023QY01)。
Inflammation plays a pivotal role in the etiology and progression of various diseases.In traditional Chinese medicine,the whole plants of Thesium chinense Turcz.and its preparations(e.g.Bairui Granules)have been emplo...
关键词：Thesium chinense ALKALOIDS NRF2 NF-ΚB NLRP3 INFLAMMATION 
Emd-D inhibited ovarian cancer progression via PFKFB4-dependent glycolysis and apoptosis
《Chinese Journal of Natural Medicines》2025年第4期431-442,共12页Xin Zhao Chao Chen Xuefei Feng Haoqi Lei Lingling Qi Hongxia Zhang Haiying Xu Jufeng Wan Yan Zhang Baofeng Yang 
funded by the Natural Science Foundation of Heilongjiang Province(No.LH2023H012);Postdoctoral Research Initiation Fund(No.LBH-Q20152);CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-078)。
Ovarian cancer poses a significant threat to women's health,necessitating effective therapeutic strategies.Emd-D,an emodin derivative,demonstrates enhanced pharmaceutical properties and bioavailability.In this study,C...
关键词：Ovarian cancer Emd-D GLYCOLYSIS APOPTOSIS PFKFB4 
Esculetin triggers ferroptosis via inhibition of the Nrf2-xCT/GPx4 axis in hepatocellular carcinoma
《Chinese Journal of Natural Medicines》2025年第4期443-456,共14页Zhixin Qu Jing Zeng Laifeng Zeng Xianmei Li Fenghua Zhang 
supported by the Natural Science Foundations of Fujian Province(Nos.2021J05063 and 2023J01541);a startup grant for High-level Talents of Fujian Medical University(No.XRCZX2021014)。
Esculetin,a natural dihydroxy coumarin derived from the Chinese herbal medicine Cortex Fraxini,has demonstrated significant pharmacological activities,including anticancer properties.Ferroptosis,an iron-dependent form...
关键词：ESCULETIN Ferroptosis Hepatocellular carcinoma Nrf2-xCT/GPx4 axis ZEBRAFISH 
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