《Chinese Journal of Natural Medicines》

作品数：2657被引量：15494H指数：43
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《Chinese Journal of Natural Medicines》
主办单位：中国药科大学;中国药学会
最新期次：2025年2期更多>>
发文主题：英文化学成分天然药物中药NEW更多>>
发文领域：医药卫生生物学化学工程文化科学更多>>
发文作者：梁敬钰余伯阳孔令义李萍王峥涛更多>>
发文机构：中国药科大学中国科学院中国医学科学院北京协和医学院第二军医大学更多>>
发文基金：国家自然科学基金国家高技术研究发展计划国家重点基础研究发展计划中国博士后科学基金更多>>
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General expert consensus on the application of network pharmacology in the research and development of new traditional Chinese medicine drugs
《Chinese Journal of Natural Medicines》2025年第2期129-142,共14页Shao Li Wei Xiao 
supported by the National Medical Products Administration Commissioned Research Project (No.20211440216);the National Administration of Traditional Chinese Medicine Science and Technology Project (No.GZY-KJS-2024-03);the State Key Laboratory of Drug Regulatory Science Project (No.2023SKLDRS0104);the Basic Research Program Natural Science Fund-Frontier Leading Technology Basic Research Special Project of Jiangsu Province (No.BK20232014);the Programs Foundation for Leading Talents in National Administration of Traditional Chinese Medicine of China“Qihuang scholars”Project;the Tianjin Administration for Market Regulation Science and Technology Key Projects (No.2022-W35)。
The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three ...
关键词：Network pharmacology Research and development of new traditional Chinese medicine drugs Expert consensus 
Research progress in methods of acquisition,structure elucidation,and quality control of Chinese herbal polysaccharides
《Chinese Journal of Natural Medicines》2025年第2期143-157,共15页Tingting Wang Baojie Zhu Jing Zhao Shaoping Li 
supported by the Science and Technology Development Fund,Macao SAR (Nos.0075/2022/A and028/2022/ITP);the Zhuhai Science and Technology Plan Project in the Social Development Field (No.2220004000117);the University of Macao (Nos.MYRG-GRG2023-00082-ICMS-UMDF/CPG2024-00011-ICMS)。
The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness.However,the precise active components underlying each prescription remain in...
关键词：Chinese medicine POLYSACCHARIDE Extraction and purification Structural analysis Quality control 
Metabolic insights into gut microbiota in the pharmacology of natural medicines
《Chinese Journal of Natural Medicines》2025年第2期158-168,共11页Zixin Chen Junchi Zhou Xiao Zheng Hao Xie Haiping Hao 
supported by the National Key Research and Development Program of China (No.2021YFA1301300);the Na-tional Natural Science Foundation of China (Nos.82321005 and 82274009);the“Double-first”Discipline Funding of China Pharmaceutical University (No.CPUQNJC22_09);the Natural Science Foundation of Jiangsu Province of China (No.SKLNMZZ202202)。
Natural medicines(NMs)demonstrate distinct advantages in the clinical management of chronic diseases.Recent years have seen growing recognition of the gut microbiota's role in the efficacy and synergy of NMs,providing...
关键词：Natural medicines Gut microbiota Metabolic signals PHARMACOKINETICS Drug discovery 
A comprehensive review on wedelolactone:natural sources,total synthesis,and pharmacological activities
《Chinese Journal of Natural Medicines》2025年第2期169-181,共13页Haiping Cai Yue Wu Xiaojin Zhang 
supported by the National Natural Science Foundation of China (No.82322062);Jiangsu Province Funds for Distinguished Young Scientists (No.BK20211527)。
Plant-derived natural products have long been a vital source for developing therapeutic drugs.Wedelolactone(WDL),a coumestan isolated from Eclipta prostrata,Wedelia calendulacea,Wedelia chinensis,and Sphagneticola tri...
关键词：Natural product Wedelolactone Pharmacological activity SYNTHESIS MECHANISM 
Metabolomics as an emerging tool for the pharmacological and toxicological studies on Aconitum alkaloids
《Chinese Journal of Natural Medicines》2025年第2期182-190,共9页Han Ding Yamin Liu Sifan Wang Yuqi Mei Linnan Li Aizhen Xiong Zhengtao Wang Li Yang 
supported by the National Natural Science Foundation of China (No.82274223)。
Aconitum(Ranunculaceae)has a long-standing history in traditional Chinese medicine(TCM),where it has been widely used to treat conditions such as rheumatoid arthritis(RA),myocardial infarction,and heart failure.Howeve...
关键词：Metabolomics Aconitum alkaloids Biomarkers METABOLITES Metabolic pathway 
Capsaicin(CAP)exerts a protective effect against ethanol-induced oxidative gastric mucosal injury by modulating the chemokine receptor 4(CCR4)/Src/p47phox signaling pathway both in vitro and in vivo
《Chinese Journal of Natural Medicines》2025年第2期191-202,共12页Zhiru Yang Haolin Guo Pengfei Zhang Kairui Liu Junli Ba Xue Bai Shiti Shama Bo Zhang Xiaoning Gao Jun Kang 
supported by the High-level Talent Research Start-up Project Funding of Henan Academy of Sciences (No.252028037)。
Ethanol(EtOH)is a common trigger for gastric mucosal diseases,and mitigating oxidative stress is essential for attenuating gastric mucosal damage.Capsaicin(CAP)has been identified as a potential agent to counteract ox...
关键词：CAPSAICIN Gastric mucosal damage Chemokine signaling NF-κB p65 
Nigella sativa L.seed extract alleviates oxidative stress-induced cellular senescence and dysfunction in melanocytes
《Chinese Journal of Natural Medicines》2025年第2期203-213,共11页Ben Niu Xiaohong An Yongmei Chen Ting He Xiao Zhan Xiuqi Zhu Fengfeng Ping Wei Zhang Jia Zhou 
supported by the National Natural Science Foundation of China (Nos.81973410 and 82473537);the Independent Research Fund of Yunnan Characteristic Plant Extraction Laboratory (Nos.2022YKZY002 and 2022YKZY004)。
Nigella sativa L.seeds have been traditionally utilized in Chinese folk medicine for centuries to treat vitiligo.This study revealed that the ethanolic extract of Nigella sativa L.(HZC)enhances melanogenesis and mitig...
关键词：Nigella sativa L.seed extract(HZC) MELANIN ROS VITILIGO Cellular senescence 
A quinolinyl analog of resveratrol improves neuronal damage after ischemic stroke by promoting Parkin-mediated mitophagy
《Chinese Journal of Natural Medicines》2025年第2期214-224,共11页Qingqi Meng Yan Mi Libin Xu Yeshu Liu Dong Liang Yongping Wang Yan Wang Yueyang Liu Guoliang Chen Yue Hou 
supported by the National Natural ScienceFoundation of China (No.82174076);the Construction Project of Liaoning Provincial Key Laboratory,China (No.2022JH13/10200026);the Fundamental Research Funds for the Central Universities (No.N2220002);the 111 Project (No.B16009);the Research Project of Educational Commission of Liaoning Province (No.LJ212410164003)。
Ischemic stroke(IS)is a prevalent neurological disorder often resulting in significant disability or mortality.Resveratrol,extracted from Polygonum cuspidatum Sieb.et Zucc.(commonly known as Japanese knotweed),has bee...
关键词：(E)-4-(3 5-dimethoxystyryl)quinoline RESVERATROL Ischemic stroke MITOPHAGY PARKIN 
Xanthones from Garcinia pedunculata and Garcinia nujiangensis and their anti-inflammatory activity
《Chinese Journal of Natural Medicines》2025年第2期225-233,共9页Xiaojie Fan Yufeng Jia Jiaxin Guo Jinyuan Yang Dahong Li Huiming Hua 
Ten novel xanthones,garpedunxanthones A-G(1-5,6a/6b,7a/7b) and nujiangxanthone Q(8),along with sixteen known analogs(9-24),were isolated from Garcinia pedunculata and G.nujiangensis.Their structures were elucidated th...
关键词：Garcinia pedunculata Garcinia nujiangensis XANTHONES Network pharmacology ANTI-INFLAMMATION 
Ent-pimarane and ent-kaurane diterpenoids from Siegesbeckia pubescens and their anti-endothelial damage effect in diabetic retinopathy
《Chinese Journal of Natural Medicines》2025年第2期234-244,共11页Mengjia Liu Tingting Luo Rongxian Li Wenying Yin Fengying Yang Di Ge Na Liu 
supported by the National Natural Science Foundation of China (No.82073728);the Natural Science Foundation of Shandong Province (No.ZR2021MH357)。
Diabetic retinopathy,a prevalent and vision-threatening microvascular complication of diabetes mellitus,is the leading cause of blindness among middle-aged and elderly individuals.Natural diterpenoids isolated from Si...
关键词：Siegesbeckia pubescens Natural diterpenoid Diabetic retinopathy Oxidative stress Inflammatory response 
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