《Bone Research》

作品数：498被引量：2896H指数：25
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《Bone Research》
主办单位：四川大学
最新期次：2024年4期更多>>
发文主题：BONEHOMEOSTASISSKELETALOSTEOARTHRITISOSTEOCLAST更多>>
发文领域：医药卫生自动化与计算机技术自然科学总论文化科学更多>>
发文基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划广东省自然科学基金更多>>
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Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases
《Bone Research》2024年第4期745-765,共21页Renpeng Zhou Weirong Hu Peter X.Ma Chuan-ju Liu 
supported by NIH research grants R01AR062207,R01AR061484,R01AR076900,R01AR078035,and R01NS070328。
Bone and joint-related diseases,including osteoarthritis(OA),rheumatoid arthritis(RA),and bone tumors,pose significant health challenges due to their debilitating effects on the musculoskeletal system.14-3-3 proteins,...
关键词：DISEASES offering DATING 
Cross-talk of inflammation and cellular senescence:a new insight into the occurrence and progression of osteoarthritis
《Bone Research》2024年第4期766-782,共17页Zeyu Han Ketao Wang Shenglong Ding Mingzhu Zhang 
supported by the Beijing Hospitals Authority’s Ascent Plan;the National Natural Science Foundation of China (82272473,82402805);the Talent Development Plan for High-level Public Health Technical Personnel Project (Subject leader-02-23);the Beijing Natural Science Foundation Haidian Original Innovation Joint Fund (L212010);the Priming Scientific Research Foundation for the Junior Researcher in Beijing Tongren Hospital (2023-YJJ-ZZL-016)。
Osteoarthritis (OA) poses a significant challenge in orthopedics. Inflammatory pathways are regarded as central mechanisms in the onset and progression of OA. Growing evidence suggests that senescence acts as a mediat...
关键词：INFLAMMATION OSTEOARTHRITIS SENESCENCE 
Engineering bone/cartilage organoids:strategy,progress,and application
《Bone Research》2024年第4期783-802,共20页Long Bai Dongyang Zhou Guangfeng Li Jinlong Liu Xiao Chen Jiacan Su 
financially supported by National Natural Science Foundation of China (32471396,82230071,82172098,82201716);Integrated Project of Major Research Plan of National Natural Science Foundation of China (92249303);Shanghai Committee of Science and Technology (23141900600,Laboratory Animal Research Project);Shanghai Clinical Research Plan of SHDC2023CRT01;Young Elite Scientist Sponsorship Program by China Association for Science and Technology (YESS20230049)。
The concept and development of bone/cartilage organoids are rapidly gaining momentum,providing opportunities for both fundamental and translational research in bone biology.Bone/cartilage organoids,essentially miniatu...
关键词：PREVENTION selecting PRINTING 
Cellular and molecular mechanisms underlying obesity in degenerative spine and joint diseases
《Bone Research》2024年第4期803-817,共15页Qian Xiang Zhenquan Wu Yongzhao Zhao Shuo Tian Jialiang Lin Longjie Wang Shuai Jiang Zhuoran Sun Weishi Li 
supported by the grants from the National Natural Science Foundation of China (82172480)。
Degenerative spine and joint diseases,including intervertebral disc degeneration(IDD),ossification of the spinal ligaments(OSL),and osteoarthritis(OA),are common musculoskeletal diseases that cause pain or disability ...
关键词：OBESITY METABOLISM DEGENERATIVE 
Bone loss with aging is independent of gut microbiome in mice
《Bone Research》2024年第4期980-993,共14页Xiaomeng You Jing Yan Jeremy Herzog Sabah Nobakhti Ross Campbell Allison Hoke Rasha Hammamieh R.Balfour Sartor Sandra Shefelbine Melissa A.Kacena Nabarun Chakraborty Julia F.Charles 
supported by NIH grants R01 AG046257 (JFC);the Orthopaedic Scholar Fund;the Department of Orthopaedic Surgery,Brigham and Women’s Hospital,P30 AR075042;the Joint Biology Consortium funded by P30-AR070253;performed at National Gnotobiotic Rodent Resource Center at University of North Carolina at Chapel Hill,funded by P40-OD010995,P30-DK034987;Crohn’s and Colitis Foundation;supported with resources and the use of facilities at the Richard L.Roudebush VA Medical Center,Indianapolis,IN:VA Merit#BX003751。
Emerging evidence suggests a significant role of gut microbiome in bone health.Aging is well recognized as a crucial factor influencing the gut microbiome.In this study,we investigated whether age-dependent microbial ...
关键词：METABOLISM AGING ALTERATION 
Enhanced osteogenic potential of iPSC-derived mesenchymal progenitor cells following genome editing of GWAS variants in the RUNX1 gene
《Bone Research》2024年第4期994-1008,共15页Nazir M.Khan Andrea Wilderman Jarred M.Kaiser Archana Kamalakar Steven L.Goudy Justin Cotney Hicham Drissi 
supported by NIH-R21 Award (R21AR071536) to HD;funds from Emory University。
Recent genome-wide association studies (GWAS) identified 518 significant loci associated with bone mineral density (BMD),including variants at the RUNX1 locus (rs13046645, rs2834676, and rs2834694). However, their reg...
关键词：RUNX1 potential utilized 
Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head
《Bone Research》2024年第4期1009-1030,共22页Wenkai Shao Bo Wang Ping Wang Shuo Zhang Song Gong Xiaodong Guo Deyu Duan Zengwu Shao Weijian Liu Lei He Fei Gao Xiao Lv Yong Feng 
supported by the National Natural Science Foundation of China (82472439,82270935,81974337,82102627);the Hubei Provincial Natural Science Foundation of China (2021CFB095);the Wuhan Knowledge Innovation Project (2022020801020468);the Project of Scientific Research Plan of Wuhan Municipal Health Commission (WX21Q19)。
Osteonecrosis of the femoral head(ONFH)is a common complication of glucocorticoid(GC)therapy.Recent advances demonstrate that sympathetic nerves regulate bone homeostasis,and GCs lower the sympathetic tone.Here,we sho...
关键词：SYMPATHETIC GLUCOCORTICOID FEMORAL 
KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m^(6)A modification of ATG4a to promote NPCs senescence and IVDD progression
《Bone Research》2024年第4期1031-1048,共18页Ouqiang Wu Yuxin Jin Zhiguang Zhang Hao Zhou Wenbin Xu Linjie Chen Morgan Jones Kenny Yat Hong Kwan Jianyuan Gao Kai Zhang Xiaofei Cheng Qizhu Chen Xinzhou Wang Yan Michael Li Zhenyu Guo Jing Sun Zhihua Chen Bin Wang Xiangyang Wang Shuying Shen Aimin Wu 
supported by the National Natural Science Foundation of China (82272555,82272522,82422044,82101647);Zhejiang Provincial Natural Science Foundation of China (LGF21H060010,LR22H060001,LY23H060011);Wenzhou Major Scientific and Technological Innovation Project (ZY2022010);Zhejiang Provincial Medical Technology Foundation of China (2022PY071)。
Intervertebral disc degeneration(IVDD),a disease associated with ageing,is characterised by a notable increase in senescent nucleus pulposus cells(NPCs)as IVDD progresses.However,the specific mechanisms that regulate ...
关键词：NPCs IMPAIRED DEGENERATION 
Bone Research EDITORIAL BOARD
《Bone Research》2024年第4期F0003-F0003,共1页
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
《Bone Research》2024年第4期818-831,共14页Yasmine Hachemi Simon Perrin Maria Ethel Anais Julien Julia Vettese Blandine Geisler Christian Göritz Céline Colnot 
supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases R01 AR072707 (C.C.and Ted Miclau)and R01 AR081671 (C.C.and Ralph Marcucio);Agence Nationale de la Recherche ANR-18-CE14-0033 and ANR-21-CE18-007-01 (C.C.)。
Musculoskeletal traumatic injuries(MTI)involve soft tissue lesions adjacent to a bone fracture leading to fibrous nonunion.The impact of MTI on the inflammatory response to fracture and on the immunomodulation of skel...
关键词：SKELETAL HEALING TRAUMA 
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