National Natural Science Foundation of China(82230071,82172098);Integrated Project of Major Research Plan of National Natural Science Foundation of China(92249303);Shanghai Committee of Science and Technology(23141900600,Laboratory Animal Research Project);Shanghai Clinical Research Plan of SHDC2023CRT01;Young Elite Scientist Sponsorship Program by China Association for Science and Technology(YESS20230049)。
Accumulating research has shed light on the significance of skeletal interoception,in maintaining physiological and metabolic homeostasis related to bone health.This review provides a comprehensive analysis of how ske...
National Natural Science Foundation of China(U24A20670,82372419,82072435);Tianjin Science and Technology Plan Project“Unveiling and Directing”Major Project(21ZXJBSY00130);Beijing-Tianjin-Hebei Basic Research Cooperation Project(J230020)。
Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles.Macrophages,as key immune cells,critically regulate inflammation through polarization into diff...
National Natural Science Foundation of China(82171003 and 82171002);Research and Develop Program of West China Hospital of Stomatology Sichuan University(NO.LCYJ-2022-YY-1)。
Circadian rhythm is ubiquitous in nature.Circadian clock genes such as Bmal1 and Clock form a multi-level transcription-translation feedback network,and regulate a variety of physiological and pathological processes,i...
National Natural Science Foundation of China(grant number 82272563 to B.S.);National Science and Technology Major Project of the Ministry of Science and Technology of China(grant number 2023ZD0501202 to B.S.);institutional grants allocated to the National Institute of Biological Sciences,Beijing(NIBS)from the Chinese Ministry of Science and Technology,Beijing Municipal Commission of Science and Technology,and Tsinghua University;the support from China Pharmaceutical University(grant number 3150140001 to S.F.);National Natural Science Foundation of China(grant numbers 82203653 to S.F.,82371957 to L.W.,and 82371956 to X.C.);Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes(grant number JYY2023-8 to X.C.);Research Grants Council of University Grants Committee Hong Kong(grant numbers 14113723,14108720,14121721,14202920,N_CUHK472/22,C7030-18G,T13-402/17-N,and AoE/M-402/20)。
Tissue clearing combined with high-resolution confocal imaging is a cutting-edge approach for dissecting the three-dimensional(3D)architecture of tissues and deciphering cellular spatial interactions under physiologic...
Scientific Research Training Program for Young Talents of Union Hospital,Tongji Medical College,Huazhong University of Science and Technology(F.W.),NIH/NIDCR grants DE029012 and DE029465;Department of Defense Grant PR190899(R.T.F.);Michigan Musculoskeletal Health Core Center(NIH/NIAMS P30 AR069620)。
Bone morphogenetic proteins are essential for bone regeneration/fracture healing but can also induce heterotopic ossification(HO).Understanding accessory factors modulating BMP signaling would provide both a means of ...
National Institutes of Health R01AR067859,R01DE019902,R21DE026256,R01DE029790,R01AR083224,R21AR076056,and P30AR069655。
The cranial mesenchyme,originating from both neural crest and mesoderm,imparts remarkable regional specificity and complexity to postnatal calvarial tissue.While the distinct embryonic origins of the superior and dura...
funding from the European Research Council(ERC)under the european union Horizon 2020 research and innovation program(grant agreement ERC co-LS4 ODE(AB)and ERC Synergy Grant 4D Nanoscope(GS));Deutsche Forschungsgemeinschaft DFG-Project number 501752319-TRR369-DIONE-Project No A02 and B05,FOR 2886(TP02),CRC1181(TPA01);DFG funding(450993414)Thunder Imager and the Leibniz Award(GS)。
Osteocytes are the main cells in mineralized bone tissue.Elevated osteocyte apoptosis has been observed in lytic bone lesions of patients with multiple myeloma.However,their precise contribution to bone metastasis rem...
jointly General Research Fund(17121619)of the Research Grant Council of Hong Kong;Guangdong Basic and Applied Basic Research Foundation(2024A1515010104 and 2023A1515220095);Scientific Research Foundation of Peking University Shenzhen Hospital(KYQD202100X)。
Fibrotic remodeling of nucleus pulposus(NP)leads to structural and mechanical anomalies of intervertebral discs that prone to degeneration,leading to low back pain incidence and disability.Emergence of fibroblastic ce...
National Natural Science Foundation of China(Grant Nos.82261160397,82272560);Central South University Research Programme of Advanced Interdisciplinary Studies(2023QYJC011);National Natural Science Foundation of China(Grant Nos.82472521,81922017);Hunan Provincial Science and Technology Department(2023JJ30896);Key Research and Development Program of Hunan Province(2022SK2023);Science and Technology Innovation Program of Hunan Province(2023RC1027);Major Basic Research Projects in Hunan Province(No.2024JC0004)。
Mechanical stress modulates bone formation and organization of the extracellular matrix(ECM),the interaction of which affects heterotopic ossification(HO).However,the mechanically sensitive cell populations in HO and ...
National Research Agency under the Investments for the Future program (ANR-10-IAHU-01);Filière Nationale TeteCou for financial support。
Gain-of-function mutations in fibroblast growth factor receptor(FGFR) genes lead to chondrodysplasia and craniosynostoses. FGFR signaling has a key role in the formation and repair of the craniofacial skeleton. Here, ...