《Bone Research》

作品数:514被引量:2918H指数:25
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《Bone Research》
主办单位:四川大学
最新期次:2025年1期更多>>
发文主题:BONEHOMEOSTASISSKELETALOSTEOARTHRITISOSTEOCLAST更多>>
发文领域:医药卫生自动化与计算机技术文化科学自然科学总论更多>>
发文基金:国家自然科学基金中国博士后科学基金国家重点基础研究发展计划广东省自然科学基金更多>>
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Skeletal interoception and prospective application in biomaterials for bone regeneration
《Bone Research》2025年第1期1-14,共14页Long Bai Jilong Li Guangfeng Li Dongyang Zhou Jiacan Su Changsheng Liu 
National Natural Science Foundation of China(82230071,82172098);Integrated Project of Major Research Plan of National Natural Science Foundation of China(92249303);Shanghai Committee of Science and Technology(23141900600,Laboratory Animal Research Project);Shanghai Clinical Research Plan of SHDC2023CRT01;Young Elite Scientist Sponsorship Program by China Association for Science and Technology(YESS20230049)。
Accumulating research has shed light on the significance of skeletal interoception,in maintaining physiological and metabolic homeostasis related to bone health.This review provides a comprehensive analysis of how ske...
关键词:HOMEOSTASIS BIOMATERIALS utilize 
Role of macrophage in intervertebral disc degeneration
《Bone Research》2025年第1期15-34,共20页Yiming Dou Yiming Zhang Yang Liu Xun Sun Xinyu Liu Bin Li Qiang Yang 
National Natural Science Foundation of China(U24A20670,82372419,82072435);Tianjin Science and Technology Plan Project“Unveiling and Directing”Major Project(21ZXJBSY00130);Beijing-Tianjin-Hebei Basic Research Cooperation Project(J230020)。
Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles.Macrophages,as key immune cells,critically regulate inflammation through polarization into diff...
关键词:DEGENERATION INTERVERTEBRAL INFLAMMATION 
Signaling pathway mechanisms of circadian clock gene Bmal1regulating bone and cartilage metabolism:a review
《Bone Research》2025年第1期35-47,共13页Yiting Ze Yongyao Wu Zhen Tan Rui Li Rong Li Wenzhen Gao Qing Zhao 
National Natural Science Foundation of China(82171003 and 82171002);Research and Develop Program of West China Hospital of Stomatology Sichuan University(NO.LCYJ-2022-YY-1)。
Circadian rhythm is ubiquitous in nature.Circadian clock genes such as Bmal1 and Clock form a multi-level transcription-translation feedback network,and regulate a variety of physiological and pathological processes,i...
关键词:BMAL1 METABOLISM CARTILAGE 
Deep imaging of LepR^(+)stromal cells in optically cleared murine bone hemisections
《Bone Research》2025年第1期104-120,共17页Yuehan Ni Jiamiao Wu Fengqi Liu Yating Yi Xiangjiao Meng Xiang Gao Luyi Xiao Weiwei Zhou Zexi Chen Peng Chu Dan Xing Ye Yuan Donghui Ding Ge Shen Min Yang Ronjie Wu Ling Wang Luiza Martins Nascentes Melo Sien Lin Xiaoguang Cheng Gang Li Alpaslan Tasdogan Jessalyn M.Ubellacker Hu Zhao Shentong Fang Bo Shen 
National Natural Science Foundation of China(grant number 82272563 to B.S.);National Science and Technology Major Project of the Ministry of Science and Technology of China(grant number 2023ZD0501202 to B.S.);institutional grants allocated to the National Institute of Biological Sciences,Beijing(NIBS)from the Chinese Ministry of Science and Technology,Beijing Municipal Commission of Science and Technology,and Tsinghua University;the support from China Pharmaceutical University(grant number 3150140001 to S.F.);National Natural Science Foundation of China(grant numbers 82203653 to S.F.,82371957 to L.W.,and 82371956 to X.C.);Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes(grant number JYY2023-8 to X.C.);Research Grants Council of University Grants Committee Hong Kong(grant numbers 14113723,14108720,14121721,14202920,N_CUHK472/22,C7030-18G,T13-402/17-N,and AoE/M-402/20)。
Tissue clearing combined with high-resolution confocal imaging is a cutting-edge approach for dissecting the three-dimensional(3D)architecture of tissues and deciphering cellular spatial interactions under physiologic...
关键词:TRANSPARENT SECTIONS STRAIGHT 
Discoidin domain receptor 2 is an important modulator of BMP signaling during heterotopic bone formation
《Bone Research》2025年第1期121-138,共18页Fashuai Wu Chunxi Ge Haichun Pan Yuanyuan Han Yuji Mishina Vesa Kaartinen Renny T.Franceschi 
Scientific Research Training Program for Young Talents of Union Hospital,Tongji Medical College,Huazhong University of Science and Technology(F.W.),NIH/NIDCR grants DE029012 and DE029465;Department of Defense Grant PR190899(R.T.F.);Michigan Musculoskeletal Health Core Center(NIH/NIAMS P30 AR069620)。
Bone morphogenetic proteins are essential for bone regeneration/fracture healing but can also induce heterotopic ossification(HO).Understanding accessory factors modulating BMP signaling would provide both a means of ...
关键词:inhibited HEALING MODULATOR 
Differential bone and vessel type formation at superior and dura periosteum during cranial bone defect repair
《Bone Research》2025年第1期139-150,共12页Yuankun Zhai Zhuang Zhou Xiaojie Xing Mark Nuzzle Xinping Zhang 
National Institutes of Health R01AR067859,R01DE019902,R21DE026256,R01DE029790,R01AR083224,R21AR076056,and P30AR069655。
The cranial mesenchyme,originating from both neural crest and mesoderm,imparts remarkable regional specificity and complexity to postnatal calvarial tissue.While the distinct embryonic origins of the superior and dura...
关键词:SUPERFICIAL SPECIFICITY defect 
Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis
《Bone Research》2025年第1期151-169,共19页Yewei Jia Rui Li Yixuan Li Katerina Kachler Xianyi Meng Andreas Gießl Yi Qin Fulin Zhang Ning Liu Darja Andreev Georg Schett Aline Bozec 
funding from the European Research Council(ERC)under the european union Horizon 2020 research and innovation program(grant agreement ERC co-LS4 ODE(AB)and ERC Synergy Grant 4D Nanoscope(GS));Deutsche Forschungsgemeinschaft DFG-Project number 501752319-TRR369-DIONE-Project No A02 and B05,FOR 2886(TP02),CRC1181(TPA01);DFG funding(450993414)Thunder Imager and the Leibniz Award(GS)。
Osteocytes are the main cells in mineralized bone tissue.Elevated osteocyte apoptosis has been observed in lytic bone lesions of patients with multiple myeloma.However,their precise contribution to bone metastasis rem...
关键词:HIF1Α METASTASIS HMO 
Fibrocyte enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severity
《Bone Research》2025年第1期170-182,共13页Yi Sun Yan Peng Zezhuo Su Kyle K.H.So Qiuji Lu Maojiang Lyu Jianwei Zuo Yongcan Huang Zhiping Guan Kenneth M.C.Cheung Zhaomin Zheng Xintao Zhang Victor Y.L.Leung 
jointly General Research Fund(17121619)of the Research Grant Council of Hong Kong;Guangdong Basic and Applied Basic Research Foundation(2024A1515010104 and 2023A1515220095);Scientific Research Foundation of Peking University Shenzhen Hospital(KYQD202100X)。
Fibrotic remodeling of nucleus pulposus(NP)leads to structural and mechanical anomalies of intervertebral discs that prone to degeneration,leading to low back pain incidence and disability.Emergence of fibroblastic ce...
关键词:DEGENERATION SEVERITY markedly 
Polycystin-1 regulates tendon-derived mesenchymal stem cells fate and matrix organization in heterotopic ossification
《Bone Research》2025年第1期183-196,共14页Yi Li Xu Mei Huang Yang Zhang Xin Ying Su Min Huang Nan Yu Zou Yu Rui Jiao Yu Chen Sun Ling Liu Yong Hua Lei Chang Jun Li 
National Natural Science Foundation of China(Grant Nos.82261160397,82272560);Central South University Research Programme of Advanced Interdisciplinary Studies(2023QYJC011);National Natural Science Foundation of China(Grant Nos.82472521,81922017);Hunan Provincial Science and Technology Department(2023JJ30896);Key Research and Development Program of Hunan Province(2022SK2023);Science and Technology Innovation Program of Hunan Province(2023RC1027);Major Basic Research Projects in Hunan Province(No.2024JC0004)。
Mechanical stress modulates bone formation and organization of the extracellular matrix(ECM),the interaction of which affects heterotopic ossification(HO).However,the mechanically sensitive cell populations in HO and ...
关键词:OSSIFICATION HETEROTOPIC TENDON 
FGFR antagonists restore defective mandibular bone repair in a mouse model of osteochondrodysplasia
《Bone Research》2025年第1期197-211,共15页Anne Morice Amélie de La Seiglière Alexia Kany Roman H.Khonsari Morad Bensidhoum Maria-Emilia Puig-Lombardi Laurence Legeai Mallet 
National Research Agency under the Investments for the Future program (ANR-10-IAHU-01);Filière Nationale TeteCou for financial support。
Gain-of-function mutations in fibroblast growth factor receptor(FGFR) genes lead to chondrodysplasia and craniosynostoses. FGFR signaling has a key role in the formation and repair of the craniofacial skeleton. Here, ...
关键词:MANDIBULAR DYSPLASIA facial 
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