In the rapidly advancing field of biomedical research,organoid technology has been a groundbreaking development.Organoids-three-dimensional structures derived from stem cells that replicate key structural and function...
supported by National Natural Science Foundation of China(No.82302401 to YW);the grant from Science and Technology Commission of Shanghai Municipality(Nos.23410750100,20DZ2255400 and 21XD1421300 to JX);the“Dawn”Program of Shanghai Education Commission(No.19SG34 to JX).
Cardiovascular diseases cause significant morbidity and mortality worldwide.Engineered cardiac organoids are being developed and used to replicate cardiac tissues supporting cardiac morphogenesis and development.These...
financially supported by the National Science Fund for Distinguished Young Scholars(No.82225027);the National Key Research and Development Program(No.2021YFA1101301);the National Natural Science Foundation of China(Nos.82271419,82202702,82202351,82001308,and 82271418);Shanghai Rising-Star Program(No.22QA1408200).
Stem cell-derived spinal cord organoids(SCOs)have revolutionised the study of spinal cord development and disease mechanisms,offering a three-dimensional model that recapitulates the complexity of native tissue.This r...
supported by the IADR Innovation in Oral Care Awards,the Innovation and Technology Fund(No.ITS/307/22);the National Natural Science Foundation of China(NSFC)Young Scientist Fund(No.82401187).
The convergence of organoid technology and artificial intelligence(AI)is poised to revolutionise oral healthcare.Organoids-three-dimensional structures derived from human tissues-offer invaluable insights into the com...
financially supported by National Natural Science Foundation of China(Nos.32471396,82230071,82172098);Integrated Project of Major Research Plan of National Natural Science Foundation of China(No.92249303);Shanghai Committee of Science and Technology(No.23141900600,Laboratory Animal Research Project);Shanghai Clinical Research Plan(No.SHDC2023CRT01);Shanghai Municipal Demonstration Project for Innovative Medical Device Applications(No.23SHS05700);Young Elite Scientist Sponsorship Program by China Association for Science and Technology(No.YESS20230049).
The skeletal system,composed of bones,muscles,joints,ligaments,and tendons,serves as the foundation for maintaining human posture,mobility,and overall biomechanical functionality.However,with ageing,chronic overuse,an...
supported by the National Natural Science Foundation of China(Nos.32430057,U21A20173,32201083 and 32071355);the Guangdong Basic and Applied Basic Research Foundation(No.2023B1515120055).
Cardiovascular diseases are a leading cause of death worldwide,and effective treatment for cardiac disease has been a research focal point.Although the development of new drugs and strategies has never ceased,the exis...
supported by National Natural Science Foundation of China(No.82272568);Sanming Project of Medicine in Shenzhen(No.SZSM202211019);Guangdong Basic and Applied Basic Research Foundation(Nos.2023A1515220019&2022A1515220056);“Merro”Young Physician Innovation and Development Project(No.GSKQNJJ-2023-004);Peking University Shenzhen Hospital Scientific Research Fund(No.KYQD2023297).
Bone and cartilage tissues are essential for movement and structure,yet diseases like osteoarthritis affect millions.Traditional therapies have limitations,necessitating innovative approaches.Organoid technology,lever...
Acute liver failure(ALF)is a short-term severe damage to hepatocytes caused by hepatotropic viruses,drug,etc.and accompanied by complications such as multi-organ failure and hepatic encephalopathy.1 The global inciden...
financially supported by the National Natural Science Foundation of China(No.32301123).
In recent years,the field of organoid research has undergone a remarkable transformation,heralding a new era in biomedical science.1,2 This progress is exemplified by the development of an array of sophisticated organ...
supported by the Foundation of National Center for Translational Medicine(Shanghai)SHU Branch(No.SUITM-202409).
Simulating human brain development accurately has the potential to improve our understanding of human brain development and various brain disorders.Although animal models play an indispensable role in the field of dev...