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Time is now:Preparing for the next pandemic: 《hLife》2025年第3期113-117,共5页Jun Liu George Fu Gao Kwok-Yung Yuen Lit Man Leo Poon Nan Song; part of the BIOHK2024,which was held in Hong Kong,China.We thank Kieran Gary Thow for his help in transcribing and editing the text.; At the BIOHK2024,held on September 11–14,2024,the roundtable discussion titled“Time is now:Preparing for the next pandemic,”brought together Professors Jun Liu,George Fu Gao,Kwok-Yung Yuen,Lit Man Leo Poon,and Nan ...; 关键词：PREDICTION demic DISCUSSION

ACSS2:Tumor-promoting lactyl-CoA synthetase that drives histone lactylation: 《hLife》2025年第3期118-120,共3页Katherine L.Wang Zhongsheng You; Lactate,a product of aerobic glycolysis,is frequently elevated in tumor cells due to the Warburg effect and frequent hypoxia[1].This functionally versatile molecule not only serves as a critical energy source and a bu...; 关键词：ELEVATED frequent VERSATILE

Neutrophils:Key players in the metabolic syndrome puzzle: 《hLife》2025年第3期121-131,共11页Hui Ping Yaw Sapna Devi Lai Guan Ng; supported by the National Natural Science Foun-dation of China(grant number 92374205 and W2431020)to L.G.N。; Metabolic syndrome(MetS)is a group of metabolic abnormalities associated with an increased risk of getting type 2 diabetes mellitus(T2DM)and cardiovascular disease(CVD).For many years,MetS has been viewed solely as a ...; 关键词：NEUTROPHILS adiposetissues INFLAMMATION metabolicsyndrome tissuereprogramming

Enabling the immune escaped etesevimab fully-armed against SARS-CoV-2 Omicron subvariants including KP.2: 《hLife》2025年第3期132-145,共14页Chao Su Juanhua He Yufeng Xie Yu Hu Xin Li Shitong Qiao Peipei Liu Min Huang Rong Zhang Liang Wang Zhen Chang Wenqiao Sun Ke Xu Jing Zhang Longxing Cao Pengcheng Han Xin Zhao Jianxun Qi Qihui Wang Mengsu Yang George Fu Gao; supported by the National Natural Science Foundation of China(82225021);the National Key R&D Program of China(2022YFC2303403,2021YFA1300803,2021YFA1301404).; Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is continuously evolving since 2019.Some monoclonal antibodies(mAbs)have been developed and widely used,such as etesevimab(CB6)developed by Eli-Lilly/Junshi.H...; 关键词：etesevimab(CB6) severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) receptor-binding domain(RBD) broad-spectrum and affinity-mature antibody design(BAADesign) antibody

H3N2 influenza virus characteristics in China(2019-2022):Genetic,antigenic,and infection dynamics during the COVID-19 pandemic: 《hLife》2025年第3期146-158,共13页Jiaming Li Yu Huan Qianfeng Xia Yan Li Rahat Ullah Khan Qingzhi Liu Chuanran Dou Marina Gulyaeva Alexander Shestopalov Ning Zhang Xuefeng Duan Jing Yang Hongchun Zhang Yuhai Bi; supported by the National Key R&D Program of China(2022YFC3500804 and 2023YFC2307500 to Y.L.and Y.B.);the National Natural Science Foundation of China(NSFC)(32261133524 and 32425053 to Y.B.);the Beijing Research Center for Respiratory Infectious Diseases(BJRID2025-007 to Y.B.);the CAS Southeast Asia Biodiversity Research Institute(151C53KYSB20210023 to Y.B.);the Major Project of Guangzhou National Laboratory(GZNL2023A01001 to Y.B.);the National Science and Technology Infrastructure of China(National Pathogen Resource Center-NPRC-32 to Y.B.);the CAS Project for Young Scientists in Basic Research(YSBR-086 to Y.B.);the Youth Innovation Promotion Association of CAS(Y2021034 to Y.B.);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202208 to Y.B.);the Russian Science Foundation(23-44-00026 to M.G.and A.S.).; Seasonal influenza activity significantly decreased in China during the coronavirus disease 2019(COVID-19)pandemic,yet the H3N2 virus led to three epidemic waves.Understanding the characteristics of H3N2 epidemic viru...; 关键词：influenza Avirus H3N2 geneticevolution PHYLOGENY ANTIGENICITY infection

Forging paths together:The history of U.S.-China Track II Health Dialogue and the future of Chinese-American health communication: 《hLife》2025年第2期57-60,共4页Qun Yan Mark McClellan Gordon G Liu Stephen Orlins George Fu Gao; supported by the Chinese Action Plan for Journal Excellence:the sub-project of Selecting High-level Talents for Journal Publication-Youth Talents Project(2023ZZ050501).; As two of the largest economies and countries in theworld,the People’sRepublic of China(China)and the United States of America(U.S.)both have enormous resources and innovative talents in a number of sectors.Cooperati...; 关键词：ACADEMICIAN U.S. Director

Rethinking BCG vaccine delivery for enhanced efficacy:Are two distinct routes of BCG administration better than one?: 《hLife》2025年第2期61-63,共3页Raymond Moeketsi Moseki Melissa Dalcina Chengalroyen; supported by the Fogarty HIV-associated TB training Program Fellowship(to R.M.M.);the Faculty of Health Science Start Up Emerging Researcher Award(to M.D.C);supported by the Fogarty International Center of the National Institutes of Health and the Eunice Kennedy ShriverNational Institute of Child Health&Human Development(D43 TW010559).; Despite the availability of effective tuberculosis(TB)treatments,the extended duration of therapy poses significant challenges to patient adherence.Vaccination remains a significant public healthcare milestone and cou...; 关键词：CHEMOTHERAPY VACCINE SPITE

Mechanism of microglia-mediated neuroinflammation,associated cognitive dysfunction,and therapeutic updates in Alzheimer’s disease: 《hLife》2025年第2期64-81,共18页Arpita Ghimire Sayed Abdur Rehman Aleena Subhani Mansoor A Khan Ziyaur Rahman Mohammad Kashif Iqubal Ashif Iqubal; Alzheimer’s disease(AD)and associated cognitive dysfunction are major healthcare challenges globally.Various mechanisms of pathogenesis and signaling molecules have been studied for their plausible role in disease in...; 关键词：cognitive dysfunction NEUROINFLAMMATION MICROGLIA oxidative stress and clinical trial

Epigenetic regulation of cardiac tissue development by lysine lactylation: 《hLife》2025年第2期82-97,共16页Xiaodong Luan Runhua Du Gengchen Su Cong Yan Xuelian Ren Kaide Ju Ye Jin Yang An Dan Guo Zhuang Tian He Huang Shuyang Zhang; funded by National Key Research and Development Program Funding(2023YFC3605504,to X.L);National High-Level Hospital Clinical Research Funding(2022-PUMCHB-098,to S.Z);National Natural Science Foundation of China(22277125 and 92253306 to H.H.);Natural Science Foundation of Shanghai(23ZR1474600 to H.H.);Shanghai Municipal Science and Technology Major Project(to H.H.);Tsinghua-Peking Center for Life Sciences(045-61020100123,to S.Z.).; Heart disease stands as the foremost global cause of mortality.In rodents,the heart possesses the remarkable ability for cardiac regeneration within the first 7 days post-birth.Furthermore,the transition to an oxygen-...; 关键词：cardiac tissue development multi-omics analysis H4K12la gene expression regulation

Lrrk2 promotes M1 macrophage polarization via regulating cytokine(IFN-g)and TLR4(LPS)-mediated responses: 《hLife》2025年第2期98-111,I0001-I0005,共19页Yuchen Kang Ping Gao Xiaotong Chen Xiaoyu Zhai Xi Wang Xiaojuan Han Baoqian Jia Baidong Hou Xuyu Zhou Jian Song Fuping Zhang; supported by a National Key Research and Development Project Grant(2021YFC2300502);the National Natural Science Foundation of China Grants(32370930 and 32360176).; Leucine-rich repeat kinase 2(Lrrk2)has received widespread attention as a risk gene associated with Parkinson’s disease.As the immune response attributes of Parkinson’s disease have been gradually revealed,the link ...; 关键词：leucine-rich repeat kinase 2(Lrrk2) M1 macrophage signal transducer and activator of transcription 1(STAT1)

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