NIH/National Institute on Drug Abuse,Grant/Award Number:R01 DA056739。
Countering neurodegenerative processes remains a major obstacle,although we have witnessed significant recent progress in diagnostic and therapeutic approaches.1,2,3 The lack of true tissue regeneration is partially r...
Science and Technology Innovation 2030 Major Project,Grant/Award Number:2022ZD0211600。
Population aging is sweeping across the globe,resulting in a striking prevalence of Alzheimer's disease(AD)and dementia and a heavy economic burden.Given the time window of 10-20 years from pathological initiation to ...
The blood-brain barrier(BBB),which protects the brain from foreign molecules,makes delivery of drugs to the central nervous system is challenging.Nanoparticles(NPs)have been used over the past decade as drug delivery ...
supported by NSUCTRG Research Grant(2021-2022)(CTRG-21-SEPS-11);NSU CTRGResearch Grant(2022-2023)(CTRG-23-SEPS-14).
Parkinson's disease(PD)is the second most prevalent neurodegenerative disorder worldwide.Despite extensive research,the etiology of both familial and sporadic PD remains unclear.While most PD cases are sporadic,a sign...
This perspective article delineates the significant role of hypoxic pockets—localized,transient reductions in cerebral oxygenation—and their implications for stroke neuroprotection strategies.It posits that precondi...
funded by the Independent Research Fund Denmark supporting work by Mie Kristensen and Maria Thaysen(grant no.2101-00013B);the Lundbeck Foundation,Neuroscience Academy Denmark supporting work by Petrine Wellendorph and Emil Westi(grant no.R389-2021-1596).
Stroke is a leading cause of death and disability worldwide,with ischemic stroke caused by an occluded vessel accounting for the majority of cases.Current treatments are limited to recanalization,either through thromb...
the consortium studies for making the summary association statistics data publicly available.This research was supported by the Applied Basic Research Foundation of Yunnan Province(grant numbers:202301AS070045 and 202101AY070001-115);the National Natural Science Foundation of China(grant number:81960242);the Yunnan Province Clinical Research Center for Geriatric Disease(grant number:202102AA310069);the Innovative Team of Yunnan Province(grant number:202305AS350019).
Background:Observational studies have indicated a link between liver enzymes and dementia,but the causal relationship remains uncertain.We conducted a two-sample Mendelian randomization(MR)study to investigate potenti...
supported by the National Natural Science Foundation of China(82027802,82102220,61975017,82101389,82171278);the Research Funding on Translational Medicine from Beijing Municipal Science and Technology Commission(Z221100007422023);the Beijing Hospitals Authority Clinical Medicine Development of special funding support(YGLX202325);the Nonprofit Central Research Institute Fund of Chinese Academy of Medical(2023-JKCS-09);the Beijing Association for Science and Technology Youth Talent Support Program(BYESS2022081);the Science and Technology Innovation Service Capacity Building Project of Beijing Municipal Education Commission(11000023T000002157177).
Aim:Approximately 21%of patients with cerebral venous sinus thrombosis(CVST)are refractory to anticoagulation treatment and face poor prognosis.These patients may benefit from endovascular therapy.Although numerous st...
NIH/NIDA,Grant/Award Number:R01DA056739;Academy of Medical Sciences,Grant/Award Number:Newton Advanced Fellowship NAFIR11\1010。
Immunological processes in the brain and periphery are well known to affect brain function in health and disease.However,our knowledge about the crosstalk between the immune system and the central nervous system is fa...