THERAPY

作品数：3109被引量：9914H指数：32
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A supramolecular formulation of icariin@sulfonatoazocalixarene for hypoxia-targeted osteoarthritis therapy
《Chinese Chemical Letters》2025年第1期267-271,共5页Chao Zhang Ai-Feng Liu Shihui Li Fang-Yuan Chen Jun-Tao Zhang Fang-Xing Zeng Hui-Chuan Feng Ping Wang Wen-Chao Geng Chuan-Rui Ma Dong-Sheng Guo 
supported by grants from the National Natural Science Foundation of China(Nos.82374489,U20A20259 and 22201299);the Scientific Research Program of the Tianjin Municipal Education Commission(No.2021ZD013)。
Osteoarthritis(OA)is the most prevalent joint disease and icariin is a promising drug for its treatment.However,the clinical use of icariin is hindered by poor water solubility,low bioavailability,and nonspecific rele...
关键词：Biomaterial Supramolecular chemistry CALIXARENE ICARIIN OSTEOARTHRITIS 
Phthalocyanine self-assembled nanoparticles for type I photodynamic antibacterial therapy
《Chinese Chemical Letters》2024年第12期511-516,共6页Wei Su Xiaoyan Luo Peiyuan Li Ying Zhang Chenxiang Lin Kang Wang Jianzhuang Jiang 
supported by the Central Guidance on the Local Science and Technology Development Fund of Guangxi Province(No.Gui Ke ZY22096010);Guangxi Natural Science Fundation(No.2023GXNSFAA026181);National Natural Science Foundation of China(No.51961009);BAGUI Scholar Program,Guangxi Province,China。
Most photodynamic therapies(PDT)rely on reactive oxygen species(ROS)produced by type II mecha nisms.However,since the production of type I ROS is not limited by oxygen content,making it more favorable for antimicrobia...
关键词：PHTHALOCYANINE NANOPARTICLES Photodynamic therapy Type I reactive oxygen species Antibacterial therapy 
Urchin-like piezoelectric ZnSnO_(3)/Cu_(3)P p-n heterojunction for enhanced cancer sonodynamic therapy
《Chinese Chemical Letters》2024年第12期206-213,共8页Qinyu Zhao Yunchao Zhao Songjing Zhong Zhaoyang Yue Zhuoheng Jiang Shaobo Wang Quanhong Hu Shuncheng Yao Kaikai Wen Linlin Li 
supported by the National Nature Science Foundation(No.82072065);the Fundamental Research Funds for the Central Universities(No.E2EG6802X2);the National Youth Talent Support Program。
Sonodynamic therapy(SDT)exhibits noninvasive and accuracy in cancer treatment,and has aroused widespread attention.However,the low quantum yield of inorganic sonosensitizers under ultrasound(US)stimulation leads to un...
关键词：ZnSnO_(3) Piezoelectric effect HETEROJUNCTION Chemodynamic therapy Sonodynamic therapy Reactive oxygen species 
The size-switchable microspheres co-loaded with RANK siRNA and salmon calcitonin for osteoporosis therapy
《Chinese Chemical Letters》2024年第12期214-220,共7页Xueyan Zhang Jicong Chen Songren Han Shiyan Dong Huan Zhang Yuhong Man Jie Yang Ye Bi Lesheng Teng 
supported by the National Natural Science Foundation of China(Nos.82003687,52203138);supported by the Jilin Scientific and Technological Development Program(No.20200201415JC);supported by the Finance Project of Jilin Province;China(Nos.2019SRCJ016,2020SCZT036)。
Osteoporosis is a disease of bone metabolism homeostasis imbalance with obvious bone loss,damage to bone microstructure,and increased risk of fracture.The occurrence and development of osteoporosis is related to the a...
关键词：OSTEOPOROSIS RANK siRNA Salmon calcitonin NANOCARRIERS Size-switchable microspheres 
Fe(Ⅲ)-juglone nanoscale coordination polymers for cascade chemodynamic therapy through synergistic ferroptosis and apoptosis strategy
《Chinese Chemical Letters》2024年第11期413-418,共6页Zhendong Liu Sainan Liu Bin Liu Qi Meng Meng Yuan Chunzheng Yang Yulong Bian Ping'an Ma Jun Lin 
financially supported by the National Key Research and Development Program of China(No.2022YFB3503700);the National Natural Science Foundation of China(NSFC,Nos.51929201,52102354,and 52202353);the projects for science and technology development plan of Jilin province(Nos.20220101070JC,20210402046GH,and 20220508089RC)。
Chemodynamic therapy(CDT)relying on the transformation of endogenous hydrogen peroxide(H_(2)O_(2))into cytotoxic hydroxyl radicals(·OH)based on the catalysis of Fenton/Fenton-type reactions exhibits great potentialit...
关键词：Nanoscale coordination polymers JUGLONE Tumor microenvironment Enhanced chemodynamic therapy Ferroptosis 
DNA-based nanosystems to generate reactive oxygen species for nanomedicine被引量：1
《Chinese Chemical Letters》2024年第11期25-34,共10页Zhongyu Wang Lijun Wang Huaixin Zhao 
financial support provided by the National Key R&D Program of China(No.2022YFC2603800);the National Natural Science Foundation of China(No.22274113)。
Reactive oxygen species(ROS)are essential in various pathological and physiological processes.Developing nanosystems that generate ROS in a controlled manner is of great interest for nanomedicine.DNA nanotechnology of...
关键词：DNA nanotechnology Photodynamic therapy Chemodynamic therapy Reactive oxygen species Nanomedicine 
Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy被引量：2
《Chinese Chemical Letters》2024年第11期44-56,共13页Tingting Hu Chao Shen Xueyan Wang Fengbo Wu Zhiyao He 
supported by National Key Clinical Specialties Construction Program;the National Natural Science Foundation of China(No.81602699);the Sichuan Science and Technology program(No.2019YFG0266)。
Nanoparticles that employ stimuli-responsive polymeric delivery carriers have emerged as intelligent nanoplatforms with great potential in cancer theranostics,mainly including cancer diagnosis,controlled/triggered dru...
关键词：Polymeric nanoparticles Tumor microenvironment-sensitive CHEMOTHERAPY Photothermal therapy photodynamic therapy Combination therapy 
Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy
《Chinese Chemical Letters》2024年第10期205-212,共8页Ying Gao Rong Zhou Qiwen Wang Shaolong Qi Yuanyuan Lv Shuang Liu Jie Shen Guocan Yu 
supported by the National Natural Science Foundation of China(Nos.22175107,22305140,51603184,82270531);Zhejiang Provincial Natural Science Foundation of China(Nos.LY21E030002,LY22H020003);Scientific Research Foundation of Zhejiang University City College(No.J-202104);Hangzhou Science and Technology Bureau of China(No.202203B27)。
Photodynamic therapy(PDT)has garnered significant attention as a promising approach to cancer therapy,harnessing the combined benefits of localized light treatment and the accompanying host immune response.In this stu...
关键词：BIOMIMETIC Cell membrane Metal-organic framework PHOTOTHERAPY Tumor targeting 
A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy被引量：1
《Chinese Chemical Letters》2024年第10期353-359,共7页Han Han Bi-Te Chen Jia-Rong Ding Jin-Ming Si Tian-Jiao Zhou Yi Wang Lei Xing Hu-Lin Jiang 
financially supported by the National Natural Science Foundation of China(Nos.82020108029,82073398);the National Key Research and Development Program of China(No.2022YFE0198400);supported by Double FirstRate construction plan of China Pharmaceutical University(No.CPU2022QZ18)。
Activated pancreatic stellate cells(PSCs)are the main source of collagen layer deposition and the key target in pancreatic fibrosis.However,no effective treatment specific to pancreatic fibrosis clinically,owing to th...
关键词：Pancreatic fibrosis Pancreatic stellate cells LIPOSOME PDGFRβ pPB peptide 
Research advances of nanoparticles for CAR-T therapy in solid tumors被引量：1
《Chinese Chemical Letters》2024年第9期72-82,共11页Bohan Chen Liming Gong Jing Feng Mingji Jin Liqing Chen Zhonggao Gao Wei Huang 
supported by Innovation Fund for Medical Sciences(CIFMS)(No.2021-I2M-1-026,China);National Natural Science Foundation of China(Nos.82104106,82073778)。
As one of the most promising adoptive T-cell therapies,chimeric antigen receptor T-cell(CAR-T)therapy has acquired Food and Drug Administration(FDA)approval for a variety of products and has been used successfully in ...
关键词：CAR-T therapy NANOPARTICLES Solid tumors IMMUNOTHERAPY T cell 
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