ORIGEN

作品数：68被引量：294H指数：10
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相关作者：张春明余纲林王侃田文喜秋穗正更多>>
相关机构：清华大学中华人民共和国环境保护部华北电力大学西安交通大学更多>>
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相关基金：国家自然科学基金国家科技重大专项教育部留学回国人员科研启动基金北京市自然科学基金更多>>
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Phase separation of SPIN1 through its IDR facilitates histone methylation readout and tumorigenesis
《Journal of Molecular Cell Biology》2024年第6期28-42,共15页Yukun Wang Yuhan Chen Mengyao Li Jiayue Wang Yuhan Jiang Rong Xie Yifeng Zhang Zhihua Li Zhenzhen Yan Chen Wu 
National Natural Science Foundation of China(32071277);Science and Technology Program of Hebei Province(216Z2602G);Natural Science Foundation of Hebei Province(C2021201012);Interdisciplinary Research Program of Natural Science of Hebei University(DXK202006).
Spindlin1(SPIN1)is a unique multivalent histone modification reader that plays a role in ribosomal RNA transcription,chromosome segregation,and tumorigenesis.However,the function of the extended N-terminal region of S...
关键词：SPIN1 IDR phase separation histone methylation reader TUMORIGENESIS 
AMP-activated protein kinaseβ1 orβ2 deletion enhances colon cancer cell growth and tumorigenesis
《Acta Biochimica et Biophysica Sinica》2022年第8期1140-1147,共8页Fuli Shi Zhimin Tang Shanshan Jiang Zhijuan Xiong Wansi Zhang Yuanjun Li Hui Lin Zhijun Luo Ying Ying 
This work was supported by the grants from the National Natural Science Foundation of China(No.81572753);the Science and Technology Foundation of Jiangxi Province(No.20212BAB206039);an Innovation and Entrepreneurship Grant from Jiangxi Province Bureau of Foreign Experts.
Abnormal metabolism is a major hallmark of cancer and has been validated as a therapeutic target.Adenine monophosphate-activated protein kinase(AMPK),anαβγheterotrimer,performs essential functions in cancer progres...
关键词：AMPKβ1 AMPKβ2 Warburg effect TUMORIGENESIS colon cancer 
Exposure to trace levels of metals and fluoroquinolones increases inflammation and tumorigenesis risk of zebrafish embryos被引量：2
《Environmental Science and Ecotechnology》2022年第2期12-22,共11页Dantong Jia Ruijie Zhang Jian Shao Wei Zhang Leilei Cai Weiling Sun 
the National Natural Science Foundation of China(Grant No.51925901 and 51879001).
Exposure to trace-level heavy metals and antibiotics may elicit metabolic disorder,alter protein expression,and then induce pathological changes in zebrafish embryos,despite negligible physiological and developmental ...
关键词：FLUOROQUINOLONE Metal INFLAMMATION Tumor Oxidative stress 
The role of the HIF-1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer被引量：34
《Cancer Communications》2021年第7期560-575,共16页Jing-Zi Wang Wei Zhu Jie Han Xiao Yang Rui Zhou Hong-Cheng Lu Hao Yu Wen-Bo Yuan Peng-Chao Li Jun Tao Qiang Lu Ji-Fu Wei Haiwei Yang 
supported by grants from the National Natural Science Foundation of China(81602235,81772711);the“333”project of Jiangsu Province(LGY2018055,LGY2016002);Key Provincial Talents Program of Jiangsu Province(ZDRCA2016006);the Priority Academic Program Development of Jiangsu Higher Education Institutions(JX10231801);the Provincial Initiative Program for Excellency Disciplines of Jiangsu Province(BE2016791).
Background:As a rate-limiting enzyme of glycolysis,pyruvate kinase muscle isozyme M2(PKM2)participates in tumor metabolism and growth.The regulatory network of PKM2 in cancer is complex and has not been fully studied ...
关键词：PKM2 ALYREF GLYCOLYSIS 5-methylcytidine modification bladder cancer HIF-1Α 
Lung stem cells in regeneration and tumorigenesis
《Journal of Genetics and Genomics》2021年第4期268-276,共9页Yuting Chen Yun Xue Yujuan Jin Hongbin Ji 
supported by the National Natural Science Foundation of China(81402371 to Y.J.,82030083 to H.J.,91731314 H.J.,81872312 to H.J.,82011540007 to H.J.,31621003 to H.J.);the National Basic Research Program of China(2017YFA0505501 to H.J.;2020YFA0803300 to H.J.);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19020201 to H.J.);the Basic Frontier Scientific Research Program of Chinese Academy of Science(ZDBS-LY-SM006 to H.J.);the International Cooperation Project of Chinese Academy of Sciences(153D31KYSB20190035 to H.J.)。
Adult lung is a highly quiescent organ,with extremely low cell turnover frequency.However,emerging evidences support the occurrence of repair and regeneration in pulmonary epithelia in response to various injuries.Lun...
关键词：Lung stem cells Lung cancer REGENERATION TUMORIGENESIS Pathological transition 
Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4被引量：8
《Cancer Communications》2021年第3期258-272,共15页Ting Guo Yan-Hua Bai Xiao-Jing Cheng Hai-Bo Han Hong Du Ying Hu Shu-Qin Jia Xiao-Fang Xing Jia-Fu Ji 
Natural Science Foundation of Beijing,Grant/Award Number:7132051;National Natural Science Foundation of China,Grant/Award Numbers:81301874,81972758,81872502,81802471;Interdisciplinary Medicine Seed Fund of Peking University,Grant/Award Number:BMU2018MX018;Beijing Municipal Administration of Hospitals’Youth Program,Grant/Award Number:QML20181102;National High Technology Research and Development Program of China,Grant/Award Number:2014AA020603;Science Foundation of Peking University Cancer Hospital,Grant/Award Numbers:2017-23,2020-6。
Background:Insulin gene enhancer protein 1,(ISL1),a LIM-homeodomain transcription factor,is involved in multiple tumors and is associated with insulin secretion and metabolic phenotypes.However,the role of ISL1 in sti...
关键词：gastric cancer glucose transporter 4 GLYCOLYSIS insulin gene enhancer protein 1 TUMORIGENESIS 
TRIM34 attenuates colon inflammation and tumorigenesis by sustaining barrier integrity被引量：3
《Cellular & Molecular Immunology》2021年第2期350-362,共13页Qiaoshi Lian Shanshan Yan Qi Yin Chenghua Yan Wanwei Zheng Wangpeng Gu Xinhao Zhao Weiguo Fan Xuezhen Li Liyan Ma Zhiyang Ling Yaguang Zhang Jie Liu Jinsong Li Bing Sun 
We thank Dangsheng Li for critical suggestions.We are grateful to Guomei Lin for breeding the animals and Li Li for animal management.We also acknowledge the individuals involved in technical support at the Core Facility for Cell Biology and the Animal Core Facility.This work was supported by grants from the National Key Research and Development Program of China(2018YFA0507402);the National Natural Science Foundation of China(31230024);the Chinese Academy of Sciences(XDB19000000);the National Natural Science Foundation of China(81761128009 and 81630016).
Loss of the colonic inner mucus layer leads to spontaneously severe colitis and colorectal cancer.However,key host factors that may control the generation of the inner mucus layer are rarely reported.Here,we identify ...
关键词：Colon inflammation Goblet cell Toll-like receptor TRIM34 MUC2 
Tissue specificity of DNA damage response and tumorigenesis被引量：5
《Cancer Biology & Medicine》2019年第3期396-414,共19页Siman Sun Michael DOsterman Mo Li 
supported by the National Natural Science Foundation of China (Grant No.81622035, 81672610, and 81521002)
The genome of cells is constantly challenged by DNA damages from endogenous metabolism and environmental agents.These damages could potentially lead to genomic instability and thus to tumorigenesis.To cope with the th...
关键词：DNA damage response TISSUE SPECIFICITY TUMORIGENESIS MICROENVIRONMENT cancer treatment 
Cancer stem cells and tumorigenesis被引量：10
《Biophysics Reports》2018年第4期178-188,共11页Pingping Zhu Zusen Fan 
This work was supported by the funding provided by the National Natural Science Foundation of China C91640203, 31771638）, Beijing Natural Science Foundation （7181006）, and Postdoctoral Innovative Talent Support Program to Pingping Zhu.
Cancer is one of the most serious diseases all over the world, and the cancer stem cell （CSC） model accounts for tumor initiation, metastasis, drug resistance, and relapse. The CSCs within tumor bulk have the capaci...
关键词：Cancer stem cells SELF-RENEWAL Signaling pathway TUMORIGENESIS INTERVENTION 
Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins被引量：8
《Cellular & Molecular Immunology》2017年第12期1026-1026,共1页Jason R Goldsmith Youhai H Chen 
In this article,the name of an author was listed incorrectly.The author names should have been listed as Jason R Goldsmith,Svetlana Fayngerts and Youhai H Chen.The authors regret the errors.
关键词：LISTED NAMES SMITH 
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