EPLERENONE

作品数：16被引量：38H指数：4
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相关作者：于路傅国胜何美霖黄荣杰郭玉冰更多>>
相关机构：浙江大学医学院附属第二医院哈尔滨医科大学广西医科大学第一附属医院武汉大学更多>>
相关期刊：《天津医药》《Science China(Life Sciences)》《药学进展》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金更多>>
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Huoxue Jiedu Huayu recipe(活血解毒化瘀方)inhibits macrophage-secreted vascular endothelial growth factor-a on angiogenesis and alleviates renal fibrosis in the contralateral kidneys of unilateral ureteral obstruction rats
《Journal of Traditional Chinese Medicine》2024年第3期458-467,共10页GAO Xiaomeng QIANG Panpan CHANG Jingyue FAN Lili YANG Fan XU Qingyou 
Natural Science Foundation-funded Project:Effect of Macrophage-to-Myofibroblast Transition in Contralateral Kidney of Unilateral Ureteral Obstruction Rats Through the Aldosterone/MR/SGK1 Pathway and Inhibition of Chinese Herbs(No.81873251);Natural Science Foundation-funded Project:Aldosterone Stimulates MR Activation to Induce Lymphangiogenesis in the Contralateral Kidney of UUO Rats and the Protective Effect of Yiqi Jiedu Huayu Herbs(No.82174317);Hebei Provincial Postgraduate Innovative Ability Cultivation Funding Project:Aldosterone Induced Macrophages to Secrete VEGFA to Participate in Renal Angiogenesis and the Protective Effect of Huoxue Jiedu Huayu Recipe(CXZZBS2023140);Construction Program of New Research and Development Platform and Institution,Hebei Province Innovation Ability Promotion Plan under Grant No.20567624H。
OBJECTIVE:To elucidate the mechanism by which Huoxue Jiedu Huayu recipe(活血解毒化瘀方,HJHR)regulates angiogenesis in the contralateral kidney of unilateral ureteral obstruction(UUO)rats and the mechanism by which it ...
关键词：epithelial-mesenchymal transition ALDOSTERONE EPLERENONE receptors MINERALOCORTICOID unilateral ureteral obstruction Huoxue Jiedu Huayu recipe 
Eplerenone inhibits atrial fibrosis in mutant TGF-β1 transgenic mices..被引量：4
《Science China(Life Sciences)》2016年第10期1042-1047,共6页Xiaoqing Chen Wuchang Zhang Qian Wang Lili Du Yi Yi Yan Liu Xu Liu Shengzhong Duan 
supported by National Nature Science Foundation of China(30871083);Doctoral Innovation Fund Projects from Shanghai Jiao Tong University School of Medicine(BXJ201442)
The purpose of the present study was to study the impacts of eplerenone （EPL）, an antagonist of mineralocorticoid receptors （MR）, on atrial fibrosis in a mouse model with selective fibrosis in the atrium, and to e...
关键词：EPLERENONE atrial fibrosis atrial fibroblasts MACROPHAGES TGF-Β1 
Oral eplerenone for the management of chronic central serous chorioretinopathy被引量：7
《International Journal of Ophthalmology(English edition)》2015年第2期310-314,共5页Rishi P Singh Jonathan E Sears Rumneek Bedi Andrew P Schachat Justis P Ehlers Peter K Kaiser 
AIM: To examine eplerenone(Inspra, Pfizer), a mineralocorticoid receptor antagonist, as a treatment option for chronic central serous chorioretinopathy(CSCR).METHODS: A retrospective consecutive case series was conduc...
关键词：central serous chorioretinopathy central serous retinopathy EPLERENONE subretinal fluid 
Apocynin attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction in mice被引量：10
《Acta Pharmacologica Sinica》2013年第3期352-359,共8页Yu-qiong LI Xiao-bo LI Shu-jie GUO Shao-li CHU Ping-jJn GAO Ding-liang ZHU Wen-quan NIU Nan JIA 
Aim： To investigate whether apocynin, a NADPH oxidase inhibitor, produced cardioproteictive effects in Ang II-induced hypertensive mice, and to elucidate the underlying mechanisms. Methods： C57BL/6 mice were subcuta...
关键词：angiotensin Ang II-induced hypertensive mice diastolic heart failure EPLERENONE APOCYNIN OSTEOPONTIN NADPH oxidase NOX4 
Development and validation of RP-HPLC method for estimation of eplerenone in spiked human plasma被引量：2
《Journal of Pharmaceutical Analysis》2012年第5期390-393,共4页Paraag Gide Sandeep Sonawane Abhishek Chitnis 
A rapid and simple high performance liquid chromatography （HPLC） mcthod wiih a UV detection （241 nm） was developed and validated for estimation of eplerenone from spiked human plasma. The analyte and the internal ...
关键词：EPLERENONE Liquid-liquidextraction Weighted regression HPLC-UV 
Protective Effects of Eplerenone on Podocyte Injury in Adriamycin Nephropathy Rats被引量：2
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2011年第3期329-334,共6页方展 张春 何方方 陈珊 孙希锋 朱忠华 刘建社 孟宪芳 
supported by grants from the National Natu-ral Sciences Foundation of China (Nos. 30500245, 30871174, and 31050110433);a Medicine-technology Interdiscipline grant from Huazhong University of Science and Technology (No. 2010JC041)
To investigate the protective effects of eplerenone on adriamycin-induced renal injury and the possible mechanisms involved,36 male Sprague-Dawley rats were randomly divided into control group,adriamycin nephropathy...
关键词：EPLERENONE ADRIAMYCIN NEPHROPATHY PODOCYTE TGF-Β1 DESMIN 
09010 在日获得批准和推荐的一些产品
《国外药讯》2007年第9期8-9,共2页景新（摘） 
日本药品食品卫生委员会的第一药物委员会已推荐三种新的活性成份的许可证。它们是抗高血压药eplerenone（Ⅰ）、抗癫痫药托吡酯（topiramate）（Ⅱ）及肌肉松弛剂罗库溴铵（rocuronium bromide）（Ⅲ）。
关键词：EPLERENONE 卫生委员会 产品 抗高血压药 肌肉松弛剂 活性成份 罗库溴铵 抗癫痫药 
高血压治疗药依普利酮（eplerenone）
《中国医药技术与市场》2007年第2期64-65,共2页
本品由辉瑞公司研发，2004年1月首次在美国上市，其后相续在英、法上市。
关键词：高血压治疗药 依普利酮 辉瑞公司 上市 
依普利酮在首次治疗的30天内可提高心力衰竭患者生存率
《中国药师》2006年第9期794-794,共1页肖志梅 
一项新的在心力衰竭患者中评估依普利酮作用的大规模临床（EPHESUS）研究分析显示，辉瑞公司的选择型醛固酮拮抗剂eplerenone（依普利酮，Inspra），在患者心脏病发作的30天治疗期内，有益于提高生存率。有6600例患者参与EPHESUS临床研...
关键词：心力衰竭患者 依普利酮 治疗期 生存率 EPLERENONE 心脏病学会年会 标准治疗方案 心血管死亡率 急性心肌梗死后 failure 
04102 Eplerenone治疗MI后心衰效价比好
《国外药讯》2006年第4期40-40,共1页王吉云（摘） 
2005年在瑞典召开的欧洲心脏病年会上公布了一项研究结果：在法国和西班牙，eplerenone（Ⅰ）用于治疗心肌梗死（MI）后心力衰竭可“延长寿命，价效比合理”。
关键词：EPLERENONE 治疗 效价比 心衰 MI 延长寿命 心力衰竭 心肌梗死 西班牙 心脏病 
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