MINERALOCORTICOID

作品数:12被引量:7H指数:2
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相关领域:医药卫生更多>>
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Huoxue Jiedu Huayu recipe(活血解毒化瘀方)inhibits macrophage-secreted vascular endothelial growth factor-a on angiogenesis and alleviates renal fibrosis in the contralateral kidneys of unilateral ureteral obstruction rats
《Journal of Traditional Chinese Medicine》2024年第3期458-467,共10页GAO Xiaomeng QIANG Panpan CHANG Jingyue FAN Lili YANG Fan XU Qingyou 
Natural Science Foundation-funded Project:Effect of Macrophage-to-Myofibroblast Transition in Contralateral Kidney of Unilateral Ureteral Obstruction Rats Through the Aldosterone/MR/SGK1 Pathway and Inhibition of Chinese Herbs(No.81873251);Natural Science Foundation-funded Project:Aldosterone Stimulates MR Activation to Induce Lymphangiogenesis in the Contralateral Kidney of UUO Rats and the Protective Effect of Yiqi Jiedu Huayu Herbs(No.82174317);Hebei Provincial Postgraduate Innovative Ability Cultivation Funding Project:Aldosterone Induced Macrophages to Secrete VEGFA to Participate in Renal Angiogenesis and the Protective Effect of Huoxue Jiedu Huayu Recipe(CXZZBS2023140);Construction Program of New Research and Development Platform and Institution,Hebei Province Innovation Ability Promotion Plan under Grant No.20567624H。
OBJECTIVE:To elucidate the mechanism by which Huoxue Jiedu Huayu recipe(活血解毒化瘀方,HJHR)regulates angiogenesis in the contralateral kidney of unilateral ureteral obstruction(UUO)rats and the mechanism by which it ...
关键词:epithelial-mesenchymal transition ALDOSTERONE EPLERENONE receptors MINERALOCORTICOID unilateral ureteral obstruction Huoxue Jiedu Huayu recipe 
Huoxue Jiedu Huayu recipe(活血解毒化瘀方)alleviates contralateral renal fibrosis in unilateral ureteral obstruction rats by inhibiting the transformation of macrophages to myofibroblast被引量:2
《Journal of Traditional Chinese Medicine》2023年第1期105-112,共8页XIONG Yunzhao LIU Lingjin LIU Ziqian CHEN Gege HAO Juan GAO Xiaomeng QIANG Panpan WANG Zheng XU Qingyou 
Supported by Natural Science Foundation-funded Project:Effect of Macrophage-to-Myofibroblast Transition in Contralateral Kidney of Unilateral Ureteral Obstruction Rats Through the Aldosterone/MR/SGK1 Pathway and Inhibition of Chinese Herbs(No.81873251);Natural Science Foundation-funded Project:Aldosterone-induced Macrophage Polarization-lymphatic Endothelial Cell-like Transformation Involved in Renal Fibrosis and the Protective Effect of Yiqi Jiedu Huayu Herbs(No.82205006);Youth Top Talent Project of Hebei Provincial Department of Education:Mechanism of Renal Fibrosis Induced by NF-kB/IL-8 Induced MMT in UUO Rats(BJK2022004)。
OBJECTIVE:To investigate the action and underlying mechanisms of Huoxue Jiedu Huayu recipe(活血解毒化瘀方,HJHR)against unilateral ureteral obstruction(UUO)-induced injury in the contralateral kidney.METHODS:Forty-eigh...
关键词:ureteral obstruction renal fibrosis ALDOSTERONE receptors mineralocorticoid MACROPHAGES MYOFIBROBLAST Huoxue Jiedu Huayu recipe 
Efficacy of suspended moxibustion stimulating Shenshu(BL23)and Guanyuan(CV4)on the amygdala-HPA axis in rats with kidney-Yang deficiency symptom pattern induced by hydrocortisone
《Journal of Traditional Chinese Medicine》2023年第1期113-123,共11页MIN Youjiang YAO Haihua WANG Zhiqin LUO Kaitao SUN Jie YUAN Zheng WU Huiqi CHENG Lihong 
Supported by the National Natural Science Foundation of China:Study on the Mechanism of Suspension Moxibustion with Moxa Stick in Treating Hydrocortisone Rats with Kidney-Yang Deficiency based on Hippocampus(amygdala)-HPA Axis(No.81660817)。
OBJECTIVE:To investigated the effects of suspended moxibustion stimulating Shenshu(BL23)and Guanyuan(CV4)acupoints on the amygdala and HPA axis in our rat model and elucidated the possible molecular mechanisms of moxi...
关键词:moxibustion kidney-Yang deficiency AMYGDALA HYPOTHALAMUS receptors mineralocorticoid receptors glucocorticoid 11-beta-hydroxysteroid dehydrogenase type 1 
Finally, Some Reason for Hope in Proteinuric Kidney Disease
《Open Journal of Nephrology》2022年第3期241-248,共8页Devin Teehan Christopher Tyburski Geoffrey Teehan 
Background: After years of predictable outcomes with limited tools to combat the ravages of proteinuric chronic kidney disease (CKD) associated with or without diabetes, exciting new options are available to slow the ...
关键词:Chronic Kidney Disease Sodium-Glucose Co-Transporter 2 Inhibitors Mineralocorticoid Agonists Angiotensin Receptor Blockers Angiotensin Converting Enzyme Inhibitors 
Glucocorticoid and mineralocorticoid receptor expression in critical illness:A narrative review
《World Journal of Critical Care Medicine》2021年第4期102-111,共10页Alice G Vassiliou Nikolaos Athanasiou Dimitra A Vassiliadi Edison Jahaj Chrysi Keskinidou Anastasia Kotanidou Ioanna Dimopoulou 
The glucocorticoid receptor(GCR)and the mineralocorticoid receptor(MR)are members of the steroid receptor superfamily of hormone-dependent transcription factors.The receptors are structurally and functionally related....
关键词:Mineralocorticoid receptor Glucocorticoid receptor Critical illness 11betahydroxysteroid dehydrogenase ALDOSTERONE CORTISOL 
An alternative splicing variant of mineralocorticoid receptor discovered in preeclampsia tissues and its effect on endothelial dysfunction被引量:1
《Science China(Life Sciences)》2020年第3期388-400,共13页Mengxi Guo Chengliang Zhou Gufeng Xu Lin Tang Yechun Ruan Ying Yu Xianhua Lin Dandan Wu Hao Chen Priscilla Yu Luyang Jin Yinyu Wang Yimei Wu Kamran Ullah Tanzil Ur Rahman Xinmei Liu Jianzhong Sheng Hsiao-Chang Chan Hefeng Huang 
This work was supported by the National Key Research and Development Program of China(2017YFC1001303);International Cooperation Project of China and Canada NSFC(81661128010);National Natural Science Foundation of China(31471405,81671456,and 81671412);the National Key Basic Research Program(2013CB967404).
The pathophysiology of preeclampsia(PE)remains unclear.PE spiral artery remodeling dysfunction and PE offspring cardiovascular future development has been a worldwide concern.We collected placental and umbilical arter...
关键词:PREECLAMPSIA MINERALOCORTICOID receptor ALTERNATIVE SPLICING variant OFFSPRING ENDOTHELIAL dysfunction 
Achieving control of resistant hypertension:Not just the number of blood pressure medications
《World Journal of Hypertension》2019年第1期1-16,共16页Kara Schmidt William Kelley Steven Tringali Jian Huang 
Resistant hypertension(RH) has a prevalence of around 12% and is associated with an increased risk of cardiovascular disease, progression to end-stage renal disease, and even mortality. In 2017, the American College o...
关键词:Resistant HYPERTENSION Pseudoresistance MINERALOCORTICOID receptor antagonists Device-based HYPERTENSION treatment Renal DENERVATION Carotid BARORECEPTOR activation therapy Central ARTERIOVENOUS anastomosis 
Effects of mineralocorticoid receptor antagonists on responses to hemorrhagic shock in rats被引量:1
《World Journal of Critical Care Medicine》2018年第1期1-8,共8页Kanako Yamamoto Takashi Yamamoto Masayuki Takamura Soichiro Usui Hisayoshi Murai Shuichi Kaneko Takumi Taniguchi 
AIM To evaluate the effects of mineralocorticoid receptor(MR) antagonists on mortality and inflammatory responses after hemorrhagic shock(HS) in rats.METHODS One hundred and two male Sprague–Dawley rats were randomly...
关键词:HEMORRHAGIC shock MORTALITY INFLAMMATORY response MINERALOCORTICOID receptor ANTAGONIST CYTOKINE 
Does MR play a vital role in the development of depressive disorder~
《中国药理学通报》2015年第B11期67-67,共1页
Depression is a leading cause of disability worldwide. However the biological and molecular mechanisms underlying this disorder remain to be unknown. Stress is a disposing factor in the development of depression, whic...
关键词:DEPRESSION MINERALOCORTICOID RECEPTOR GLUCOCORTICOID RECEPTOR stress 
Severe Ectopic Cushing’s Syndrome Due to ACTH-Secreting Pheochromocytoma
《International Journal of Clinical Medicine》2013年第4期228-231,共4页Aurelio Negro Enrica Manicardi Chiara Grasselli Massimiliano Babini Rosaria Santi Valeria Pugni Lucia Spaggiari Elena Tagliavini 
We report a new case of ectopic Cushing’s syndrome caused by an ACTH-producing pheochromocytoma. A 55-year-old woman presented with a history of severe proximal muscle weakness, polyuria, progressive virilization, an...
关键词:Cushing’s SYNDROME PHEOCHROMOCYTOMA APPARENT Excess of MINERALOCORTICOID SYNDROME 
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