CYSTINE

作品数：26被引量：367H指数：6
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相关领域：医药卫生理学更多>>
相关作者：王文营更多>>
相关机构：新疆医科大学首都医科大学附属北京友谊医院更多>>
相关期刊：《Cancer Communications》《Science Bulletin》《Journal of Hainan Medical University》《Journal of Pharmaceutical Analysis》更多>>
相关基金：国家自然科学基金更多>>
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CRL3 E3 ligase regulates glutamine and cystine metabolisms
《Protein & Cell》2024年第12期867-871,共5页Qiyin Zhou Zhijian Li Yi Sun 
supported by the National Key Research&Development Program of China(2021YFA1101000 and 2022YFC3401500);National Natural Science Foundation of China(82372688,92253203 and U22A20317);Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2022R01002);Zhejiang Provincial Natural Science Foundation of China(LD22H300003)。
Tumorigenesis hinges on the reprogramming of cellular metabolisms to meet the requirements of intracellular biomass,characterized by the acquisition of nutrients from the environment as a common feature(Pavlova and Th...
关键词：METABOLISM PROGRAMMING utilized 
A nanoagent for concurrent therapy of breast cancer bone metastasis and cancer-induced bone pain through SLC7A11 interruption and photodynamic therapy被引量：1
《Chinese Chemical Letters》2024年第2期295-299,共5页Qi Fu Zhongming Lian Mengya Niu Yaru Huang Yanqiu Ai Long He Dandan Zhang Cuixia Zheng Jian-Jun Yang Lei Wang Dandan Tian 
financially supported by the National Natural Science Foundation of China(No.82001189);The Project Tackling of Key Scientific and Technical Problems of Henan Provine(No.232102311163).
Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and survival.The concurrent treatmen...
关键词：Breast cancer bone metastasis Cancer-induced bone pain Cystine/glutamate antiporter SORAFENIB Photodynamic therapy 
DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson’s disease被引量：9
《Neural Regeneration Research》2023年第1期194-199,共6页Chun-Bo Hu Hui Jiang Yin Yang Guo-Hua Wang Qiu-Hong Ji Zhong-Zheng Jia Li-Hua Shen Qian-Qian Luo 
funded by the National Natural Science Foundation of China, No. 81873924 (to QQL), No. 82171190 (to GHW);Nantong Science and Technology Project of China, No. MS22021010 (to LHS);High-level Innovation and Entrepreneurship Talents Introduction Program of Jiangsu Province of China (to QQL)
DL-3-n-butylphthalide(NBP)-a compound isolated from Apium graveolens seeds-is protective against brain ischemia via various mechanisms in humans and has been approved for treatment of acute ischemic stroke.NBP has sho...
关键词：cystine/glutamate antiporter solute carrier family 7 member 11 DL-3-n-butylphthalide ferritin light chain ferroportin 1 ferroptosis glutathione peroxidase 4 oxidative stress iron ROTENONE transferrin receptor 
Cystine-assisted accumulation of gold nanoparticles on ZnO to construct a sensitive surface-enhanced Raman spectroscopy substrate
《Frontiers of Chemical Science and Engineering》2023年第1期15-23,共9页Qi Qu Chuan Zeng Jing Huang Mengfan Wang Wei Qi Zhimin He 
the National Natural Science Foundation of China(Grant Nos.21621004 and 22178260);the Tianjin Development Program for Innovation and Entrepreneurship(2018);the Cooperative Program of Technical Center of Gongbei Customs District of China(Grant No.2020GKF-0281).
Recently,various semiconductor/metal composites have been developed to fabricate surfaceenhanced Raman spectroscopy substrates.However,low metal loading on semiconductors is still a challenge.In this study,cystine was...
关键词：BIOMINERALIZATION CYSTINE semiconductor/metal composite SERS detection Raman detection 
Structure and mechanism of human cystine exporter cystinosin
《四川生理科学杂志》2022年第9期1654-1654,共1页Xue Guo 
Lysosomal amino acid efflux by proton-driven transporters is essential for lysosomal homeostasis,amino acid recycling,mTOR signaling,and maintaining lysosomal pH.To unravel the mechanisms of these transporters,we focu...
关键词：MECHANISM MECHANISM conformational 
NADPH debt drives redox bankruptcy:SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation被引量：11
《Genes & Diseases》2021年第6期731-745,共15页Xiaoguang Liu Yilei Zhang Li Zhuang Kellen Olszewski Boyi Gan 
This work was supported by the Andrew Sabin Family Fellow Award from The University of Texas MD Anderson Cancer Center,KC180131 from;Department of Defense Kidney Cancer Research Program,R01CA181196 and R01CA244144 from the National Institutes of Health(to B.G.).
Cystine/glutamate antiporter solute carrier family 7 member 11(SLC7A11;also known as xCT)plays a key role in antioxidant defense by mediating cystine uptake,promoting glutathione synthesis,and maintaining cell surviva...
关键词：CYSTEINE CYSTINE NADPH Pentose phosphate pathway SLC7A11 xCT 
Cystine supplementation rebalances the redox homeostasis of microenvironment in non-small cell lung cancer cells and reverses their resistance to docetaxel被引量：3
《Acta Pharmacologica Sinica》2021年第12期2132-2143,共12页Si-jia Li Bei Cao Zhen-yao Lu Run-bin Sun Su-han Guo Yuan Xie Ji-ye Aa Guang-ji Wang 
supported by the National Natural Science Foundation of China,grant number 81773814;"Double First-Class"University project(CPU2018GF01);Leading Technology Foundation Research Project of Jiangsu province(BK20192005);Sanming Project of Medicine in Shenzhen(SZSM201801060).
Continuous docetaxel(DTX)treatment of non-small cell lung cancer induces development of drug resistance,but the mechanism is poorly understood.In this study we performed metabolomics analysis to characterize the metab...
关键词：non-small cell lung cancer cells DOCETAXEL drug resistance metabolomics MICROENVIRONMENT redox homeostasis P-GLYCOPROTEIN CYSTINE Rosup NAC 
Quantitative determination of D_(4)-cystine in mice using LC-MS/MS and its application to the assessment of pharmacokinetics and bioavailability被引量：1
《Journal of Pharmaceutical Analysis》2021年第5期580-587,共8页Shuning Li Zhenyao Lu Li Jiao Ran Zhang Yu Hong Jiye Aa Guangji Wang 
This study was financially supported by the National Natural Science Foundation of the People's Republic of China(Grant Nos.:81773814 and 81530098);the National Key Special Project of Science and Technology for Innovation Drugs of China(Project No.:2017ZX09301013);the National Key Research and Development Program(Grant No.:2018YFC0807403).
Cystine is the primary source material for the synthesis of glutathione.However,the pharmacokinetics and tissue distribution of cystine are largely unknown.A surrogate analyte D_(4)-cystine was employed to generate ca...
关键词：CYSTINE LC-MS/MS PHARMACOKINETICS DISTRIBUTION Absolute bioavailability 
Cystine transporter SLC7A11/xCT in cancer:ferroptosis,nutrient dependency,and cancer therapy被引量：206
《Protein & Cell》2021年第8期599-620,共22页Pranavi Koppula Li Zhuang Boyi Gan 
The research in authors'lab has been supported by The University of Texas MD Anderson Cancer Center,KC180131 from Department of Defense Kidney Cancer Research Program,R01CA181196,R01CA190370,R01CA244144 from the National Institutes of Health(to BG);CPRIT Research Training Grant(RP170067);Dr.John J.Kopchick Research Award from The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences(to PK).
The cystine/glutamate antiporter SLC7A11(also commonly known as xCT)functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers.Recent studies reveal...
关键词：SLC7A11 xCT CYSTINE CYSTEINE ferroptosis nutrient dependency cancer therapy 
Biomineralization-inspired copper-cystine nanoleaves capable of laccase-like catalysis for the colorimetric detection of epinephrine被引量：1
《Frontiers of Chemical Science and Engineering》2021年第2期310-318,共9页Miao Guan Mengfan Wang Wei Qi Rongxin Su Zhimin He 
This work was supported by the National Natural Science Foundation of China(Grant Nos.21621004 and 21676191).
Recently,many efforts have been dedicated to creating enzyme-mimicking catalysts to replace natural enzymes in practical fields.Inspired by the pathological biomineralization behaviour of L-cystine,in this study,we co...
关键词：BIOMINERALIZATION LACCASE L-CYSTINE colorimetric detection enzyme mimic 
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