PRE-CLINICAL

作品数:55被引量:110H指数:6
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相关领域:医药卫生更多>>
相关作者:熊江辉更多>>
相关机构:中国航天员科研训练中心吉林大学更多>>
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相关基金:国家自然科学基金上海市浦江人才计划项目高等学校学科创新引智计划更多>>
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Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives被引量:1
《Neural Regeneration Research》2025年第11期3151-3171,共21页Fatima Aldali Chunchu Deng Mingbo Nie Hong Chen 
supported by the Key Research and Development Project of Hubei Province of China,2022BCA028(to HC)。
“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal cord.Peripheral nerve injury results in movements or sensation impairments,and represents a serious public health pro...
关键词:clinical trials EXOSOME extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments 
Influence of network latency and bandwidth on robot-assisted laparoscopic telesurgery:A pre-clinical experiment被引量:1
《Chinese Medical Journal》2025年第3期325-331,共7页Ye Wang Qing Ai Taoping Shi Yu Gao Bin Jiang Wuyi Zhao Chengjun Jiang Guojun Liu Lifeng Zhang Huaikang Li Fan Gao Xin Ma Hongzhao Li Xu Zhang 
National Natural Science Foundation of China(No.M-0735)
Background:Telesurgery has the potential to overcome spatial limitations for surgeons,which depends on surgical robot and the quality of network communication.However,the influence of network latency and bandwidth on ...
关键词:TELESURGERY LATENCY BANDWIDTH Image clarity Surgical robot 
Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications
《Signal Transduction and Targeted Therapy》2024年第12期5470-5512,共43页Yingying Shi Meixing Shi Yi Wang Jian You 
supported by the National Key R&D Program of China(2023YFC340200);the National Natural Science Foundation of China(No.82404520,82273862);the China Postdoctoral Science Foundation(2024M752834);the China National Postdoctoral Program for Innovative Talents(BX20230321).
In the last decade,messenger ribonucleic acid(mRNA)-based drugs have gained great interest in both immunotherapy and nonimmunogenic applications.This surge in interest can be largely attributed to the demonstration of...
关键词:DRUGS CLINICAL gained 
Innovative hydrogel-based delivery systems for immunotherapy:A review of pre-clinical progress
《Nano Research》2024年第10期9031-9043,共13页Narsimha Mamidi Michael Poellmann Kaila Javius-Jones KiChang Nam Seungpyo Hong 
partially supported by the National Science Foundation(NSF)(No.DMR-2211932);the National Institutes of Health(NIH)(Nos.P50CA278595 and 1R01CA262292);supported by Falk Medical Research Trust(Transformational Award);Dongkook Pharmaceuticals via an Industry Sponsored Research Agreement(SRA);Milton J.Henrichs Chair fund.
Immunotherapy has markedly reinvented how we treat cancer,as shown by numerous Food and Drug Administration(FDA)drug approvals that have made significant clinical impact and ongoing clinical trials.However,undesirable...
关键词:cancer immunotherapy drug delivery HYDROGELS immunotherapeutic agents immune modulation clinical outcomes 
The big data challenge-and how polypharmacology supports the translation from pre-clinical research into clinical use against neurodegenerative diseases and beyond
《Neural Regeneration Research》2024年第8期1647-1648,共2页Sven Marcel Stefan Muhammad Rafehi 
supported by the Walter Benjamin and Research Grant Programs of the German Research Foundation(Deutsche Forschungsgemeinschaft,DFG,Germany,#446812474,#504079349[PANABC])(to SMS),the DFG(#437446827);the Research Program of the University Medical Center Gottingen(to MR)。
Introductory comments:The identification and validation of disease-modifying proteins are fundamental aspects in drug development.However,the m ultifactority of n eurodegen era tive diseases poses a real challenge for...
关键词:TRANSLATION BEYOND LIKELY 
Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models
《Neural Regeneration Research》2024年第8期1728-1733,共6页Sanika M.Joshi Theresa Currier Thomas Nafisa M.Jadavji 
Salary for TCT was supported by National Institutes of Health Grant(R01NS100793)。
Traumatic brain injury is a major cause of death and disability worldwide,affecting over 69 million individuals yearly.One-carbon metabolism has been shown to have beneficial effects after brain damage,such as ischemi...
关键词:folic acid NICOTINAMIDE one-carbon metabolism RIBOFLAVIN traumatic brain injury vitamin B12 vitamin B2 vitamin B3 
Physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis
《Neural Regeneration Research》2024年第8期1768-1771,共4页Federica Azzolini Ettore Dolcetti Antonio Bruno Valentina Rovella Diego Centonze Fabio Buttari 
In multiple sclerosis,only immunomodulato ry and immunosuppressive drugs are recognized as disease-modifying therapies.Howeve r,in recent years,several data from pre-clinical and clinical studies suggested a possible ...
关键词:disease-modifying behaviour endocannabinoid system long-term potentiation multiple sclerosis NEUROPLASTICITY NEUROPROTECTION physical exercise synaptopathy 
From Simulation to Reality: A Comprehensive Study on the Efficacy of a Rotating Monopolar and Bipolar Radiofrequency System through In-Silico Modeling and Pre-Clinical and Clinical Validation
《Journal of Biomedical Science and Engineering》2024年第6期107-128,共22页Gregorio Viera Mármol Ana Lorena Urbano Bojorge Alicia Robledo Jorge José Antonio Ferrández Martínez Olalla Calvo Lozano 
Background: Skin aging is an unavoidable process aggravated by environmental agents. Among other energy devices, non-invasive radiofrequency (RF) technology is widely used for skin tightening and body contouring as it...
关键词:Comsol Multiphysics Simulations Radiofrequency Skin Tightening Fat Reduction Body Contouring CELLULITE 
Knowledge and Attitudes of Knust Pre-Clinical Dental Students towards Orthodontic Treatment
《Open Journal of Stomatology》2024年第1期1-13,共13页Ama Agyeibea Amuasi Ama B. Yeboah Daniel K. Sabbah 
Background: Orthodontics is a dental specialty focusing on correcting dental irregularities and malocclusion. Knowledge and attitudes towards orthodontic treatment are crucial for promoting oral health and overall wel...
关键词:Orthodontic Therapy Pre-Clinical Dentistry Students Quantitative Study Convenience Sampling Interview-Administered Questionnaire MALOCCLUSION 
Astragaloside Ⅳ for Heart Failure: Preclinical Evidence and Possible Mechanisms, A Systematic Review and Meta-Analysis
《Chinese Journal of Integrative Medicine》2023年第7期626-633,共8页LI Xing-xing LI Dong CUI Xiao-yun ZHOU Kun LIU Jing LU Jin-jin WU Yang LIN Qian LI Yan 
Supported by National Natural Science Foundation of China(No.81973622);Capital’s Funds for Health Improvement and Research(No.2020-2-4201)。
Objective:To explore the cardioprotective effects of astragaloside Ⅳ(AS-Ⅳ) in heart failure(HF).Methods:PubMed,Excerpta Medica Database(EMBASE),Cochrane Library,Web of Science,Wanfang Database,Chinese Bio-medical Li...
关键词:astragaloside IV heart failure pre-clinical evidence systematic review 
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