云南高校图书馆联盟文献共享服务平台- MONOPHOSPHATE

MONOPHOSPHATE: 作品数：92被引量：261H指数：8; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：肖明芳应汉杰杨晓亮吕浩何明芳更多>>; 相关机构：南京工业大学南京大学福建中医药大学中国人民解放军第一军医大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金福建省自然科学基金国家重点基础研究发展计划广东省自然科学基金更多>>

All-small-molecule supramolecular hydrogels assembled from guanosine 5′-monophosphate disodium salt and tobramycin for the treatment of bacterial keratitis被引量：3: 《Bioactive Materials》2022年第10期293-300,共8页Xuejing Cheng Huiyu Chen Fang Yang Jiaxu Hong Yiyun Cheng Jingjing Hu; from the Natural Science Foundation of Shanghai(19ZR1415600);the National Natural Science Foundation of China(81970766 and 82171102);the Program for Professor of Special Appointment(Estern Scholar)at Shanghai Institutions of Higher Learning,the Shanghai Innovation Development Program(2020-RGZN-02033);the Shanghai Key Clinical Research Program(SHDC2020CR3052B);the Fundamental Research Funds for the Central Universities.; Bacterial keratitis is the most common corneal infection which may lead to blindness,and seriously threatened the human visual health worldwide.Clinical treatment with antibiotic eye drops formulation usually falls in...; 关键词：HYDROGEL Supramolecular gel Antibacterial hydrogel AMINOGLYCOSIDE Bacterial keratitis

Molecular Similarity within Carcinogen and Guanine Cyclic Nucleotide Structures: 《Journal of Biosciences and Medicines》2022年第5期86-94,共9页Wynford Robert Williams; Tumor promoters, apoptosis and autophagy modulators, chemotherapy drugs, and endogenous steroids demonstrate molecular similarity relative to cyclic nucleotide structure. This study explores relative molecular similar...; 关键词：ANESTHETICS Cancer CARCINOGENS Guanosine Cyclic Monophosphate Molecular Similarity

Cyclic Nucleotide Structural Differentiation of Compounds Modulating Apoptosis and Drug Resistance被引量：2: 《Journal of Biosciences and Medicines》2021年第8期10-28,共19页Wynford Robert Williams; Carcinogenesis is associated with malfunction in the cGMP-mediated regulation of cytosolic Ca²⁺ and reactive oxygen species. Chemotherapy resistant cancer cells are re-sensitised to apoptosis by the action ...; 关键词：Cancer CHEMOTHERAPY Guanosine Cyclic Monophosphate Molecular Similarity Multidrug Resistance

Endogenous nucleotide as drug carrier:base-paired guanosine-5’-monophosphate:pemetrexed vesicles with enhanced anticancer capability: 《Science China Chemistry》2020年第2期244-253,共10页Lei Xu Chunyang Yu Dali Wang Ji Pang Leilei Shi Yue Su Lidong Gong Deyue Yan Xinyuan Zhu; supported by the Shanghai Municipal Government(18JC1410800);the National Natural Science Foundation of China(51690151,21774077); Endogenous substance such as nucleotide as a drug carrier has been proposed as a novel drug delivery system.The nucleotide guanosine-5’-monophosphate(GMP) is used to transport an anticancer drug pemetrexed disodium h...; 关键词：endogenous carrier hydrogen bonding NANOVESICLES drug delivery cancer therapy

Transformation of microstructure and phase of disodium guanosine 5′-monophosphate: Thermodynamic perspectives被引量：1: 《Chinese Journal of Chemical Engineering》2018年第10期2112-2120,共9页Qiao Chen Fengxia Zou Pengpeng Yang Jingwei Zhou Jinglan Wu Wei Zhuang Hanjie Ying; Supported by the Program for Changjiang Scholars and Innovative Research Team in University(IRT_14R28);the National Basic Research Program of China(2013CB733602);the Major Research Plan of the National Natural Science Foundation of China(21390204);the National Natural Science Foundation of China(21636003,21506090);Open Fund by Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals(JSBGFC14005);Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD); Microstructure and phase transformation of disodium guanosine 5′-monophosphate(5′-GMPNa_2) are extremely important for controlling the process and understanding the mechanism of crystallization. In this work, the th...; 关键词：Solid form transformation THERMODYNAMICS Disodium guanosine 5′-monophosphate SOLUBILITY CRYSTALLIZATION Intermolecular force

Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension被引量：2: 《World Journal of Gastroenterology》2018年第38期4356-4368,共13页Denise Schaffner Adhara Lazaro Peter Deibert Peter Hasselblatt Patrick Stoll Lisa Fauth Manfred W Baumstark Irmgard Merfort Annette Schmitt-Graeff Wolfgang Kreisel; AIM To investigate the potential effect of inhibitors of phosphodiesterase-5(PDE-5) for therapy of portal hypertension in liver cirrhosis.METHODS In the rat model of thioacetamide-induced liver fibrosis/cirrhosis the ...; 关键词：Portal hypertension THIOACETAMIDE Nitric oxide Liver cirrhosis Cyclic GUANOSINE MONOPHOSPHATE Phosphodiesterase-5 SILDENAFIL Hepatic stellate cells Metabolic zonation

Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models被引量：6: 《World Journal of Gastroenterology》2018年第17期1888-1900,共13页Illona-Marie Boulete Anusha Thadi Catherine Beaufrand Viren Patwa Apoorva Joshi John A Foss E Priya Eddy Helene Eutamene Vaseem A Palejwala Vassilia Theodorou Kunwar Shailubhai; Supported by Synergy Pharmaceuticals Inc.,which provided the funding and the plecanatide,dolcanatide and placebo used for these studies; AIM To investigate the effects of plecanatide and dolcanatide on maintenance of paracellular permeability, integrity of tight junctions and on suppression of visceral hypersensitivity. METHODS Transport of fluorescein...; 关键词：Plecanatide Guanylyl cyclase-C AGONISTS Dolcanatide UROGUANYLIN PRECLINICAL cyclic GUANOSINE MONOPHOSPHATE Constipation Inflammatory bowel diseases

Guanylyl cyclase C signaling axis and colon cancer prevention被引量：2: 《World Journal of Gastroenterology》2016年第36期8070-8077,共8页Amanda M Pattison Dante J Merlino Erik S Blomain Scott A Waldman; Supported by NIH,No.R01CA170533,No.R01CA206026 and No.P30CA56036;Targeted Diagnostic and Therapeutics,Inc.;a Ruth L.Kirschstein National Research Service Award for Individual Predoctoral MD/PhD Fellows from the NIH,No.CA180500(To Blomain ES);a Ruth L.Kirschstein National Research Service Award for Individual Predoctoral MD/PhD Fellows from the NIH,No.F30 DK103492(To Merlino DJ);a Predoctoral Fellowship in Pharmacology/Toxicology from the PhR MA Foundation; Colorectal cancer(CRC) is a major cause of cancerrelated mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, a...; 关键词：Colorectal cancer GUANYLIN UROGUANYLIN Chemoprevention Heat-stable ENTEROTOXINS Cyclic GUANOSINE MONOPHOSPHATE Guanylyl CYCLASE C

Kv7通道在正常及高血压大鼠钠尿肽介导的血管舒张中的作用被引量：1: 《中华高血压杂志》2015年第1期66-66,共1页赵狄练桂丽 Stott JB Barrese V Jepps TA Leighton EV Greenwood IA; 电压门控性钾通道Kv7家族可在血管表达,是血管张力的关键调节因素,能介导环磷酸腺苷（3＇,5＇-cyclic adenosine monophosphate,cAMP）关联的内源性血管舒张反应——高血压的一个受损通路。但Kv7通道在非cAMP关联的血管舒张反应通路中...; 关键词：Kv7 血管舒张高血压大鼠 MONOPHOSPHATE 钠尿肽受体环磷酸鸟苷 adenosine 信号通路 GUANOSINE 心房钠尿肽

Analytical Solutions of Nonlinear Differential Equations in the Mathematical Model for Inactivation of Nitric Oxide by Rat Cerebellar Slices: 《American Journal of Analytical Chemistry》2014年第14期908-919,共12页Narayanan Mehala Lakshmanan Rajendran; A mathematical model for the inactivation of nitric oxide by rat cerebellar slices under non-steady state condition has been analyzed. This diffusion-inactivation model was used to estimate the kinetics of NO consumpt...; 关键词：Cyclic GUANOSINE MONOPHOSPHATE (CGMP) INACTIVATION Mathematical Modeling Nitric Oxide Rat CEREBELLAR Slices

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