PHARMACOLOGIC

作品数：41被引量：267H指数：7
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相关领域：医药卫生更多>>
相关作者：王琪赵连根陈玉玲陈家童朱柞铭更多>>
相关机构：首都医科大学天津中西医结合急腹症研究所复旦大学南开大学更多>>
相关期刊：《Journal of Animal Science and Biotechnology》《Journal of Cosmetics, Dermatological Sciences and Applications》《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金更多>>
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Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification
《Bone Research》2024年第4期863-876,共14页Manyu Zhu Ji-Hye Yea Zhao Li Qizhi Qin Mingxin Xu Xin Xing Stefano Negri Mary Archer Monisha Mittal Benjamin Levi Aaron W.James 
supported by NIH/NIAMS (P01 AG066603,R01 AR079171,R01 AR079171-07S1,R21AR078919);NIH/NIDCR (R01 DE031488,R01 DE031028);Alex’s Lemonade Stand Foundation (22-26743);American Cancer Society (DBG-23-1155131-01-IBCD);the Maryland Stem Cell Research Foundation (2021-MSCRFD-5641);Department of Defense (USAMRAA HT9425-24-1-0051);supported by NIH/NIAMS (R01 AR079171-07,R01 AR079171-07S1)。
Heterotopic ossification(HO)is a pathological process that commonly arises following severe polytrauma,characterized by the anomalous differentiation of mesenchymal progenitor cells and resulting in the formation of e...
关键词：NERVES TRAUMATIC alterations 
The Sigma-1 Receptor as a Pharmacologic Chaperone: Energetics
《Journal of Biosciences and Medicines》2024年第8期347-356,共10页Robert B. Raffa Joseph V. Pergolizzi Jr. 
Initially thought to be an opioid receptor subtype, Sigma-1 receptors (S1R) are now known to be unique proteins that have chaperone-like properties. As such, they play critical roles in cellular signaling, homeostasis...
关键词：CHAPERONE Sigma-1 Receptor ENERGETICS THERMODYNAMICS Isothermal Titration Microcalorimetry 
A proteomic landscape of pharmacologic perturbations for functional relevance
《Journal of Pharmaceutical Analysis》2024年第1期128-139,共12页Zhiwei Liu Shangwen Jiang Bingbing Hao Shuyu Xie Yingluo Liu Yuqi Huang Heng Xu Cheng Luo Min Huang Minjia Tan Jun-Yu Xu 
supported by the Natural Science Foundation of China(Grant Nos.:22225702 and 32322048);the National Key R&D Program of China(Grant No.:2020YFE0202200);the Shanghai Academic/Technology Research Leader Program,China(Grant No.:22XD1420900);Guangdong High-level New R&D Institute,China(Grant No.:2019B090904008);Guangdong High-level Innovative Research Institute,China(Grant No.:2021B0909050003);the Shanghai Rising-Star Program,China(Grant No.:22QA1411100);the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Grant No.:2021276);the Young Elite Scientists Sponsorship Program by China Association for Science and Technology,China(Grant No.:2022QNRC001);the open fund of State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,China(Grant No.:KF-202201);We also thank the support of the Innovative Research Team of High-Level Local Universities in Shanghai,China(Grant No.:SHSMU-ZDCX20212700);Sanofi scholarship program.
Pharmacological perturbation studies based on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic platform to profile the whole proteome ...
关键词：PROTEOMICS Drug PERTURBATION Drug target Drug combination 
A Non-Invasive Skin Treatment Combining LED with Pharmacologic and Ultrasonic Technologies for Facial Rejuvenation
《Journal of Cosmetics, Dermatological Sciences and Applications》2023年第4期333-344,共12页Keely Marsh Bianca Coppa Katie Matten Richard Parker Yohei Tanaka 
Background: Non-invasive facial treatments have the ability to rejuvenate the facial profile when specific pharmacologic agents and modalities are prescribed and used in combination taking into consideration each pati...
关键词：LED Non-Invasive Skin Treatment Pharmacologic Agents REJUVENATION Ul-trasonic Technology 
Anti-hepatic carcinoma mechanisms of calycosin through targeting ferroptosis
《Intelligent Medicine》2023年第3期173-179,共7页Litao Nie Yimei Liao Rui Zhou Xiao Liang Xiaowei Wan Xin Li Min Su 
supported by the National Natural Science Foundation of Guangxi (Grant No.2020GXNSFBA159066).
Background Ferroptosis,a pathologic state induced by lipid-driven oxidative stress,is associated with the development of human cancers.Calycosin,a natural compound with antioxidant and anti-inflammatory activities,has...
关键词：Hepatic carcinoma Ferroptosis CALYCOSIN BIOINFORMATICS Pharmacologic target 
Exploration of the oxidative-inflammatory potential targets of Coicis Semen in osteoarthritis:Data mining and systematic pharmacology被引量：1
《BIOCELL》2023年第7期1623-1643,共21页QIAO ZHOU JIAN LIU LING XIN YANYAN FANG LEI WAN DAN HUANG JIANTING WEN 
supported by the Anhui Famous Traditional Chinese Medicine Liu Jian Studio Construction Project(Traditional Chinese Medicine Development Secret[2018]No.11);the Ministry of Science and Technology National Key Research and Development Program Chinese Medicine Modernization Research Key Project(No.2018YFC1705204);Anhui Province Traditional Chinese Medicine Leading Talent Project(Traditional Chinese Medicine Development Secret[2018]No.23);the Anhui key Research and Development Program Foreign Science and Technology Cooperation Project(No.201904b11020011);the Anhui Provincial Education Department Project(No.2022AH050449).
On the basis of data mining,systematic pharmacology,molecular docking,and experiment validation,the oxidative-inflammatory molecular targets of Coicis Semen in the therapy of osteoarthritis(OA)were explored.Methods:Th...
关键词：Pharmacologic actions Chinese herbal medicine OSTEOARTHRITIS Random walk model Molecular docking 
Human-induced pluripotent stem cell-atrial-specific cardiomyocytes and atrial fibrillation
《World Journal of Clinical Cases》2022年第27期9588-9601,共14页Wattana Leowattana Tawithep Leowattana Pathomthep Leowattana 
Patient-specific human-induced pluripotent stem cell-derived atrial cardiomyocytes(hiPSC-aCMs) may be produced,genome-edited,and differentiated into multiple cell types for regenerative medicine,disease modeling,drug ...
关键词：Atrial fibrillation Human-induced pluripotent stem cell-derived atrial cardiomyocytes Disease modeling Maturation Pharmacologic response Personalized medicine 
Management of sleep disorders among children and adolescents with neurodevelopmental disorders: A practical guide for clinicians被引量：3
《World Journal of Clinical Pediatrics》2022年第3期239-252,共14页Michael O Ogundele Chinnaiah Yemula 
There is a complex relationship between sleep disorders and childhood neurodevelopmental,emotional,behavioral and intellectual disorders(NDEBID).NDEBID include several conditions such as attention deficit/hyperactivit...
关键词：Sleep Emotional Behavioural difficulties Neurodevelopmental disorders PHARMACOTHERAPY Non-pharmacologic interventions Cognitive therapy MELATONIN Adolescents PSYCHOEDUCATION 
Pharmacologic RNA splicing modulation: a novel mechanism to enhance neoantigen-directed anti-tumor immunity and immunotherapy response
《Signal Transduction and Targeted Therapy》2021年第11期3167-3168,共2页Kerryn Elliott Jonas Nilsson Jimmy Van den Eynden 
Open access funding provided by University of Gothenburg.
A recent study by Lu et al.1 suggests a novel approach to increasing responsiveness to immune checkpoint blockade (ICB) therapy. ICB is a promising form of cancer immunotherapy that aims to boost the anti-tumoral immu...
关键词：IMMUNITY IMMUNOTHERAPY mostly 
Pharmacologic management of post-tonsillectomy pain in children被引量：3
《World Journal of Otorhinolaryngology-Head and Neck Surgery》2021年第3期186-193,共8页Daniel R.Jensen 
Tonsillectomy is a very common procedure in children,often performed on an outpatient basis.Severe postoperative pain is common,and can be prolonged.Despite a large number of available analgesic medications,often empl...
关键词：Pediatric tonsillectomy Tonsillectomy pain Postoperative analgesia 
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