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WILD-TYPE: 作品数：121被引量：282H指数：8; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：牟珍珍姚庆宇王丽杰袁茵李静云更多>>; 相关机构：北京大学第四军医大学西京医院四川省肿瘤医院中国医学科学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金天津市自然科学基金更多>>

Predictive and prognostic implications of 4E-BP1, Beclin-1, and LC3for cetuximab treatment combined with chemotherapy in advanced colorectal cancer with wild-type KRAS: Analysis from real-world data被引量：6: 《World Journal of Gastroenterology》2019年第15期1840-1852,共13页Gui-Fang Guo Yi-Xing Wang Yi-Jun Zhang Xiu-Xing Chen Jia-Bin Lu Hao-Hua Wang Chang Jiang Hui-Quan Qiu Liang-Ping Xia; BACKGROUND Colorectal cancer(CRC) is one of the main causes of cancer-related deaths in China and around the world. Advanced CRC(ACRC) patients suffer from a low cure rate though treated with targeted therapies. The r...; 关键词：4E-binding PROTEIN 1 BECLIN-1 Microtubule-associated PROTEIN 1A/B-light chain 3 Advanced colorectal cancer CETUXIMAB efficacy Prognosis

Synergistic anticancer effect of exogenous wild-type p53 gene combined with 5-FU in human colon cancer resistant to 5-FU in vivo被引量：4: 《World Journal of Gastroenterology》2016年第32期7342-7352,共11页Qi Xie Min-Yi Wu Ding-Xuan Zhang Yi-Ming Yang Bao-Shuai Wang Jing Zhang Jin Xu Wei-De Zhong Jia-ni Hu; Supported by the Natural Science Foundation of Guangdong,No.2015A030313732; AIM To investigate the anticancer effect of a recombinant adenovirus-mediated p53(r Ad-p53) combined with 5-fluorouracil(5-FU) in human colon cancer resistant to 5-FU in vivo and the mechanism of r Ad-p53 in reversal ...; 关键词：Human colon cancer MULTIDRUG resistance 5-FLUOROURACIL Recombinant adenovirus-mediated p53 XENOGRAFTS in NUDE mice

Role of molecular analysis in the adjuvant treatment of gastrointestinal stromal tumours: It is time to define it: 《World Journal of Gastroenterology》2013年第16期2583-2586,共4页Margherita Nannini Maria A Pantaleo Guido Biasco; Sendur et al pointed out the attention on the importance of mutational analysis for adjuvant treatment of gastrointestinal stromal tumor (GIST) in an article published in World Journal of Gastroenterology . In particu...; 关键词：GASTROINTESTINAL STROMAL tumours Plateletderived growth factor receptor alpha KIT WILD-TYPE Molecular analysis IMATINIB ADJUVANT treatment

Stem cell factor-mediated wild-type KIT receptor activation is critical for gastrointestinal stromal tumor cell growth被引量：1: 《World Journal of Gastroenterology》2012年第23期2929-2937,共9页Chen-Guang Bai Xiao-Wei Hou Feng Wang Cen Qiu Yan Zhu Ling Huang Jing Zhao Jing-Jing Xu, Da-Lie Ma; Supported by The National Natural Science Foundation of China, No.30700809 and No.30972876; AIM: To clarify the biological role of stem cell factor (SCF)-mediated wild-type KIT receptor activation in gastrointestinal stromal tumor (GIST) growth. METHODS: The co-expression of wild-type KIT receptor and SCF wa...; 关键词：Gastrointestinal stromal tumor Stem cellfactor Wild-type KIT receptor Cell growth In vitro

Construction and expression of eukaryotic plasmids containing lamivudine-resistant or wild-type strains of Hepatitis B Virus genotype C被引量：3: 《World Journal of Gastroenterology》2008年第23期3733-3738,共6页Wei-Zhen Xu Yong Fang Di Li Yan Wang Qing-Long Shang Gui-Qiu Li Xu Teng Hong-Xi Gu; The PhD Foundation of Education Ministry, China, No. 20050226002;the Doctor Foundation of Harbin Medical University; The Youth Foundation of Heilongjiang Province, No. QC06C061;The Foundation of Education Department, Heilongjiang Province, No. 11521089; AIM:To construct eukaryotic expression plasmids of full-length Hepatitis B Virus(HBV) genotype C genome,which contain lamivudine-resistant mutants(YIDD,YVDD) or wild-type strain(YMDD) ,and to observe the expression of...; 关键词：Hepatitis B virus Lamivudine-resistant mutant Wild-type strain

Growth inhibitory effect of wild-type Kras2 gene on a colonic adenocarcinoma cell line被引量：3: 《World Journal of Gastroenterology》2007年第6期934-938,共5页Hong Li Hou-Fa Cao Jun Wan Yuan Li Mei-Ling Zhu Po Zhao; a grant from National Natural Science Foundation of China for Young Scholars, No. 30200326; AIM： To observe the growth inhibitory effect of wild-type Kras2 gene on a colonic adenocarcinoma cell line Caco-2. METHODS： Recombinant plasmid pCI-neo-Kras2 with wild type Kras2 open reading frame was constructed. ...; 关键词：Colonic adenocarcinoma Wild-b/pe Kras2 Cell cycle APOPTOSIS

Expression level of wild-type survivin in gastric cancer is an independent predictor of survival被引量：26: 《World Journal of Gastroenterology》2004年第22期3245-3250,共6页HuaMeng Cai-DeLu Yu-LeiSun De-JianDai Sang-WongLee NobuhikoTanigawa; Supported by the National Natural Science Foundation of China,No.30271483;Grant-in-Aid from the Japanese Ministry of Education,Culture,Sports,Science,and Technology of Japan,No.13470262; AIM: Survivin is a novel antiapoptotic gene in which three splicing variants have been recently cloned and characterized. Survivin has been found to be abundantly expressed in a wide variety of human malignancies, whe...; 关键词：基因表达外生性胃癌肿瘤成活率消化系统

Effects of dendritic cells transfected with full-length wild-type p53 and stimulated by gastric cancer lysates on immune response被引量：6: 《World Journal of Gastroenterology》2004年第17期2595-2597,共3页Hua-WenSun Qi-BingTang Yong-JunCheng Sheng-QianZou; AIM: To investigate the effects of dendritic cells (DCs) transfected with full-length wild-type p53 and stimulated by gastric cancer lysates on immune response.METHODS: The wild-type p53 was transduced to DCs with ade...; 关键词：树枝状细胞基因转染全长性野生性 P53 刺激作用胃癌肿瘤溶解产物免疫反应消化系统

Reversal of 5-flouroucial resistance by adenovirus-mediated transfer of wild-type p53 gene in multidrug-resiatant human colon carcinoma LoVo/5-FU cells被引量：7: 《World Journal of Gastroenterology》2004年第13期1979-1983,共5页Zhi-WeiYu PengZhao MingLiu Xin-ShuDong JiTao Xue-QinYao Xin-ttuaYin YuLi Song-BinFu; AIM: To observe the reversal effects of wide-type p53 gene on multi-drug resistance to 5-FU (LOVO/5-FU).METHODS: After treatment with Ad-p53, LOVO/5-FU sensitivity to 5-Fu was investigated using tetrazolium dye assay....; 关键词：反向作用 5-氟抵抗力腺病毒调节作用基因表达野生型 P53基因多药炕药性结肠癌肿瘤 LoVo/5-FU

Synergetic anticancer effect of combined quercetin and recombinant adenoviral vector expressing human wild-type p53,GM-CSF and B7-1 genes on hepatocellular carcinoma cells in vitro被引量：28: 《World Journal of Gastroenterology》2003年第1期73-78,共6页MingShi Fu-ShengWang Zu-ZeWu; AIM: This study investigated the anti-cancer effect ofcombined quercetin and a recombinant adenovirus vectorexpressing the human p53, GM-CSF and B7-1 genes(designated BB-102) on human hepatocellular carcinoma(HCC) cel...; 关键词：栎精腺病毒载体肝细胞癌肿瘤细胞肿瘤抑制野生型P53 GM-CSF B7-1基因

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