NEUROD

作品数：32被引量：51H指数：5
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相关领域：医药卫生更多>>
相关作者：徐剑文张素华邵伟任伟郭玮更多>>
相关机构：福建医科大学中山大学苏州大学重庆医科大学附属第一医院更多>>
相关期刊：《Maternal-Fetal Medicine》《Science China(Life Sciences)》《Frontiers in Biology》《中国组织化学与细胞化学杂志》更多>>
相关基金：国家自然科学基金重庆市自然科学基金国家重点基础研究发展计划福建省教育厅科技项目更多>>
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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system
《Neural Regeneration Research》2025年第8期2420-2432,共13页Lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li 
supported by the National Nature Science Foundation of China,No.32101020(to JL);the Natural Science Foundation of Shandong Province,Nos.ZR2020MC071(to JL),ZR2023MH327(to HZ);the Integrated Project of Major Research Plan of National Natural Science Foundation of China,No.92249303(to PL);the Natural Science Foundation of Qingdao,No.23-2-1-193-zyyd-jch(to HZ)。
The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding domains.Variants of the CNKS...
关键词：autism spectrum disorder CENTROSOME CNKSR2 intellectual disability INTERACTOME mass spectrometry MICROTUBULE neurodevelopmental disease protein complexes protein-protein interactions 
Targeting protein aggregation for the treatment of neurodegenerative diseases
《Medicine Plus》2024年第1期3-7,共5页Qingchao Li Wei Pan Jun Zhou Haiyang Yu Songbo Xie 
supported by the National Natural Science Foundation of China(32270892 and 32070708).
Pathological protein aggregation is a prevalent characteristic of major age-related neurodegenerative diseases,including Alzheimer's disease(AD),Huntington's disease(HD),amyotrophic lateral sclerosis(ALS),frontotempor...
关键词：aggregation NEUROD protein DEGENERATIVE diseases TARGETING TREATMENT 
Synaptic alterations as a common phase in neurological and neurodevelopmental diseases: JNK is a key mediator in synaptic changes
《Neural Regeneration Research》2023年第3期531-532,共2页Clara Alice Musi Carlo Bonadonna Tiziana Borsello 
funded by Ricerca Finalizzata 2016 RF-2016-02361941;MIUR,-PON“Ricerca e Innovazione”PerMedNet id project ARS01_01226-PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE Prot.2017MYJ5TH;312 European Commission’s Horizon 2020 research and innovation program,No.847749。
Brain synapses play a key role in neuronal communication:this“conversation”is at the basis of all brain activities and synaptic dysfunction leads to brain disorders.We study the modulators of this crucial synaptic f...
关键词：alterations diseases NEUROLOGICAL 
Modeling human neurodevelopmental diseases with brain organoids被引量：4
《Cell Regeneration》2022年第1期1-13,共13页Xiaoxiang Lu Jiajie Yang Yangfei Xiang 
This work was supported by the Shanghai Pujiang Program(20PJ1410400);National Natural Science Foundation of China(32170836);the ShanghaiTech University start-up fund。
Studying the etiology of human neurodevelopmental diseases has long been a challenging task due to the brain’s complexity and its limited accessibility.Human pluripotent stem cells(hPSCs)-derived brain organoids are ...
关键词：Brain organoids Neurodevepmental diseases Disease modeling Stem cells Gene editing 
Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage
《Journal of Genetics and Genomics》2022年第7期654-665,共12页Elisabetta Morini Dadi Gao Emily M.Logan Monica Salani Aram J.Krauson Anil Chekuri Yei-Tsung Chen Ashok Ragavendran Probir Chakravarty Serkan Erdin Alexei Stortchevoi Jesper Q.Svejstrup Michael E.Talkowski Susan A.Slaugenhaupt 
supported by National Institutes of Health grants (R37NS095640 to S.A.S.);the Francis Crick Institute (to PC and JQS)
Familial dysautonomia(FD), a hereditary sensory and autonomic neuropathy, is caused by a mutation in the Elongator complex protein 1(ELP1) gene that leads to a tissue-specific reduction of ELP1 protein. Our work to ge...
关键词：ELP1 Elongator Transcriptional elongation Familial dysautonomia Neurodevelopmental disease 
The Relationship Between the Gut Microbiome and Neurodegen-erative Diseases被引量：6
《Neuroscience Bulletin》2021年第10期1510-1522,共13页Xueling Zhu Bo Li Pengcheng Lou Tingting Dai Yang Chen Aoxiang Zhuge Yin Yuan Lanjuan Li 
by a National Key Science and Technology Project of China(2018YFC2000500,03);the National Natural Science Foundation of China(81790631 and 81703430);the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-045)。
Many recent studies have shown that the gut microbiome plays important roles in human physiology and pathology.Also,microbiome-based therapies have been used to improve health status and treat diseases.In addition,agi...
关键词：Gut microbiome Neurodegenerative diseases Aging 16S rRNA sequencing Multi-omics Microbiome-based therapies 
Neurodevelopmental Outcome After Fetoscopic Laser Surgery for Twin-twin Transfusion Syndrome:A Systematic Review of Follow-up Studies from the Last Decade
《Maternal-Fetal Medicine》2020年第3期154-161,共8页Knijnenburg Patricia J.C. Lopriore Enrico Oepkes Dick Vreeken Nienke Tan Ratna N.G.B. Rijken Monique van Klink Jeanine M.M. 
Objective:To review the literature on long-term neurodevelopmental outcome after fetoscopic laser surgery for twin-twin transfusion syndrome(TTTS).Methods:A literature search in PubMed,Embase,Emcare,Web of Science,Coc...
关键词：Cerebral palsy Fetofetal transfusion Fetoscopic laser surgery Neurodevelopmental impairment Neurodevelopmental outcome 
Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model被引量：5
《Microsystems & Nanoengineering》2020年第1期754-767,共14页Kangli Cui Yaqing Wang Yujuan Zhu Tingting Tao Fangchao Yin Yaqiong Guo Haitao Liu Fei Li Peng Wang Yuejun Chen Jianhua Qin 
This research was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Nos.XDB32030200,XDB29050301,XDA16020900);the National Science and Technology Major Project(No.2018ZX09201017-001-001);the National Key R&D Program of China(No.2017YFB0405400);the National Nature Science Foundation of China(Nos.31671038,31971373);the Innovation Program of Science and Research from the DICP,CAS(DICP TMSR201601).
Prenatal exposure to environmental insults can increase the risk of developing neurodevelopmental disorders.Administration of the antiepileptic drug valproic acid(VPA)during pregnancy is tightly associated with a high...
关键词：markedly inhibited EXPOSURE 
Neurodevelopmental Problems in Children at 9 Months of Age Associated with Neonatal Hypoxic-Ischemic Encephalopathy被引量：1
《Open Journal of Pediatrics》2017年第2期98-108,共11页Evelyn Mungyeh Mah Seraphin Nguefack Hélène Kamo Selangai Andréas Chiabi Mbassi Awa Félicité Dongmo Mazou Ngou Temgoua Elie Mbonda 
Introduction: Neonatal asphyxia is a major cause of infant morbidity in Cameroon. The aim of this study was to describe the short-term neurological outcome of children following neonatal Hypoxic-ischemic encephalopath...
关键词：Hypoxic-Ischemic ENCEPHALOPATHY Cerebral PALSY Mental RETARDATION Cameroon 
MODY 6的研究、认识现状及处理
《实用糖尿病杂志》2017年第2期3-4,共2页汤学军 王黎 张风 王波 刘国良 
苏州市科技支撑计划SS201222
遗传目前已经是大家十分熟习的术语，实质上真正被人们认识是一个历史的漫长过程：最早人们的认识是从临床和流行病学角度，比如糖尿病，最早表示糖尿病是一种遗传病的是现代医学之父William Oslei爵士；在1893年把糖尿病归属“体质性...
关键词：神经元分化因子 (NEUROD) 1突变 
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