GINKGOLIDE

作品数：12被引量：37H指数：5
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相关领域：医药卫生更多>>
相关作者：史琳娜张怡敏寇静周雪宁环诚更多>>
相关机构：中国药科大学陕西中医药大学江苏康缘药业股份有限公司中药制药过程新技术国家重点实验室更多>>
相关期刊：《Chinese Medical Journal》《Chemical Research in Chinese Universities》《Chinese Journal of Natural Medicines》《Neural Regeneration Research》更多>>
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Effects of Ginkgo biloba extract EGb761 on neural differentiation of stem cells offer new hope for neurological disease treatment被引量：6
《Neural Regeneration Research》2019年第7期1152-1157,共6页Chao Ren Yong-Qiang Ji Hong Liu Zhe Wang Jia-Hui Wang Cai-Yi Zhang Li-Na Guan Pei-Yuan Yin 
funded by the National Natural Science Foundation of China,No.81501185(to CR);the Key Research&Development Project of Shandong Province of China,No.2017GSF218043(to CR);the Science and Technology Planning Project of Yantai of China,No.2016WS017(to LNG),2017WS105(to HL)
Stem cell transplantation has brought new hope for the treatment of neurological diseases.The key to stem cell therapy lies in inducing the specific differentiation of stem cells into nerve cells.Because the different...
关键词：nerve REGENERATION GINKGO biloba extract GINKGOLIDE B traditional Chinese medicine STEM cells induction of differentiation STEM cell transplantation synaptic plasticity pharmacological effect NEUROLOGICAL diseases nervous systems neural REGENERATION 
Effects of adjuvant ginkgolide injection therapy in perioperative period of hypertensive cerebral hemorrhage on neural functional recovery
《Journal of Hainan Medical University》2018年第12期67-70,共4页Hong-Ying Gao 
Objective: To study the effects of adjuvant ginkgolide injection therapy in perioperative period of hypertensive cerebral hemorrhage on neural functional recovery. Methods: Patients with hypertensive cerebral hemorrha...
关键词：Hypertension CEREBRAL HEMORRHAGE GINKGOLIDE INFLAMMATORY RESPONSE Stress RESPONSE 
Applying risk management to analytical methods for the desorbing process of ginkgo diterpene lactone meglumine injection被引量：5
《Chinese Journal of Natural Medicines》2018年第5期366-374,共9页XU Fang-Fang BI Yu-An HUANG Wen-Zhe WANG Zhen-Zhong XIAO Wei 
supported by a grant from the National Ministry of Science and Technology(No.2013ZX09402203)
Analysis errors can occur in the desorbing process of ginkgo diterpene lactone meglumine injection(GDMI) by a conventional analysis method, due to several factors, such as easily crystallized samples, solvent volatili...
关键词：Risk management Near-infrared Mid-infrared Desorbing PROCESS GINKGOLIDE A GINKGOLIDE B 
鲍曼不动杆菌通过活化血小板激活因子受体引起感染人支气管上皮细胞的氧化应激和细胞凋亡被引量：7
《细胞与分子免疫学杂志》2018年第5期421-426,共6页张怡敏 张宏方 周雪宁 徐洋洋 王媛媛 叶峥嵘 史琳娜 环诚 寇静 
陕西省教育厅专项科研计划(17JK0200);陕西中医药大学自然科学青年基金(2016QN29)
目的探讨血小板激活因子受体(PAFR)在鲍曼不动杆菌(A.baumannii)感染人支气管上皮(HBE)细胞过程中的作用。方法 HBE细胞分为对照组、银杏内酯B(GB)处理组、A.baumannii感染组、A.baumannii感染联合GB处理组。使用临床分离的A.baumannii...
关键词：鲍曼不动杆菌 血小板激活因子受体(PAFR) HBE细胞 银杏内酯B(ginkgolide B) 
银杏二萜内酯有效部位(GA,GB,GK)配伍活性研究被引量：5
《中国中药杂志》2018年第7期1410-1415,共6页张红 罗燕平 曹泽彧 张新庄 曹亮 王振中 萧伟 
国家“重大新药创制”科技重大专项(2013ZX09402203);江苏省科技成果转化项目(BA2010109)
研究银杏二萜内酯（ginkgolide）A,B,K（GA,GB,GK）最佳活性配伍。比较化合物GA,GB,GK单用,两两配伍及三者配伍对PAF诱导的血小板聚集活性及大鼠脑缺血再灌注模型（tMCAO）的影响。GA,GB,GK不同配伍均可明显降低血小板活化因子（platele...
关键词：GINKGOLIDE A GINKGOLIDE B GINKGOLIDE K 血小板活化因子 血小板聚集 tMCAO神经损伤 
Influence of ginkgolide combined with edaravone on the brain function of elderly patients with acute cerebral infarction and its preventive effect on ischemia reperfusion injury
《Journal of Hainan Medical University》2017年第24期121-125,共5页Ju-Rong Li 
Objective: To explore the influence of ginkgolide combined with edaravone on the brain function of elderly patients with acute cerebral infarction and its preventive effect on ischemia reperfusion injury. Methods: A t...
关键词：Acute CEREBRAL INFARCTION GINKGOLIDE EDARAVONE Brain function ISCHEMIA REPERFUSION injury 
Ginkgolide K protects the heart against ER stress injury by activating the IRE1α/XBP1 pathway被引量：1
《中国药理学与毒理学杂志》2016年第10期1009-1010,共2页WANG Shou-bao WANG Zhen-zhong FAN Qi-ru GUO Jing GINA GA-LI DU Guan-hua WANG Xin XIAO Wei 
OBJECTIVE Here we investigated the effects and the underlying mechanism of Ginkgolide K(1,10-dihydroxy-3,14-didehydroginkgolide,GK)on cardiac ER stress.METHODS Cell death,apoptosis,and ER stressrelated signalling path...
关键词：Ginkgolide K ER stress IRE1α XBP1 ER-associated degradation AUTOPHAGY 
Ginkgolide K protects cardiomyocytes against ER stress through stimulating ER-associated degradation （ERAD） and autophagy
《中国药理学通报》2015年第B11期181-182,共2页
Aim Endoplasmic reticulum （ER） stress is increasingly recognized as an important contributor to the pathophysiology of many diseases, and therapeutic interventions that target ER stress response emerge as new thera-...
关键词：GINKGOLIDE K ER stress NEONATAL rat CARDIOMYOCYTES (NRCMs) ER-associated degradation (ERAD) AUTOPHAGY 
Ginkgolide C Stimulates CFTR-mediate Anion Conductance in Distal Colon:Implication for Therapy of Gastrointestinal Diseases
《Chemical Research in Chinese Universities》2009年第6期909-913,共5页LIAO Qi MA Xiao-yan WU Fu-ju YANG Li-xiao WANG Shuai 
Supported by Changchun Municipal Science and Technology Fund(No.2008116);Science and Technology Fund of Jilin Province(No.20090464)
The effects and the mechanisms of natural compounds ginkgolides on CFTR-mediate anion transport were investigated. The CFTR-mediate iodide influx rates were studied via a cell-based fluorescence assay done for FRT cel...
关键词：GINKGOLIDE Cystic fibrosis transmembrane conductance regulator Fluorescence MUCOSA 
Improving effect of Ginkgolide B on mitochondrial respiration of ischemic neuron after cerebral thrombosis in tree shrews被引量：13
《Chinese Medical Journal》2007年第17期1529-1533,共5页LI Shu-qing ZHANG Ying YANG Li-jun 
the grants from Specialized Research Fund for the Doctoral Program of Higher Education(No.20050678008);National Natural Science Foundation of China (No.3066005).
Background It has been known that platelet activating factor receptors （PAFR） may mediate many acute pathological responses and that PAFR antagonist Ginkgolide B （GB） possesses multiple effects, but the actions of...
关键词：PHOTOCHEMISTRY cerebral ischemia MITOCHONDRIA GINKGOLIDE tree shrews 
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