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  • 期刊=Signal Transduction and Targeted Therapyx
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Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein
《Signal Transduction and Targeted Therapy》2024年第7期2970-2983,共14页Qi Yang Bao Xue Fengjiang Liu Yongzhi Lu Jielin Tang Mengrong Yan Qiong Wu Ruyi Chen Anqi Zhou Lijie Liu Junjun Liu Changbin Qu Qingxin Wu Muqing Fu Jiayi Zhong Jianwei Dong Sijie Chen Fan Wang Yuan Zhou Jie Zheng Wei Peng Jinsai Shang Xinwen Chen 
supported by the Natural Science Foundation of Guangdong province(Grant no.2024A1515011589 to Q.Y.);the National Natural Science Foundation of China(Grant no.32000111 to Q.Y.,82170473 to J.S.);the Pearl River Talent Recruitment Program(Grant no.2019CX01Y422 to X.C.);the Guangzhou Laboratory(Grant no.SRPG22-002 to J.S.and X.C.,No.SRPG22-011 to W.P.and Q.Y.);the Basic and Applied Basic Research Projects of Guangzhou Basic Research Program(2023A04J0161 to Q.Y.,2021QN020451 to J.S.);the Young Elite Scientists Sponsorship Program by CAST(Grant no.2023QNRC001 to F.L.).
Respiratory syncytial virus(RSV)is the major cause of bronchiolitis and pneumonia in young children and the elderly.There are currently no approved RSV-specific therapeutic small molecules available.Using high-through...
关键词：NEUTRAL METASTABLE approved 
The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodeling被引量：5
《Signal Transduction and Targeted Therapy》2023年第12期5904-5918,共15页Jiaorong Qu Bojun Qiu Yuxin Zhang Yan Hu Zhixing Wang Zhiang Guan Yiming Qin Tongtong Sui Fan Wu Boyang Li Wei Han Xiaozhong Peng 
supported by the CAMS Innovation Fund for Medical Sciences(CIFMS)grant(2021-I2M-1-034);the National Key R&D Program of China(2022YFC3401002);the National Natural Science Foundation of China(82173373).
Glioma is the most prevalent brain tumor,presenting with limited treatment options,while patients with malignant glioma and glioblastoma(GBM)have poor prognoses.The physical obstacle to drug delivery imposed by the bl...
关键词：GLIOMA invasion HOMEOSTASIS 
E3 ligase MG53 suppresses tumor growth by degrading cyclin D1被引量：1
《Signal Transduction and Targeted Therapy》2023年第8期3768-3779,共12页Meng Fang Hong-Kun Wu Yumeng Pei Yan Zhang Xiangyu Gao Yanyun He Gengjia Chen Fengxiang Lv Peng Jiang Yumei Li Wenwen Li Peng Jiang Lin Wang Jiafu Ji Xinli Hu Rui-Ping Xiao 
This project was funded by National Key R&D Program of China(2018YFA0800701,2018YFA0507603,and 2018YFA0800501);National Natural Science Foundation of China(81770376,81630008,81790621,31521062,31671177,and 81370234);Beijing Natural Science Foundation(5182010);Beijing Municipal Science&Technology Commission(Z171100000417006).
Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle,aberrant cyclin D1 expression is a major oncogenic event in many types of cancers.In particular,the dysregulation of ubi...
关键词：MG53 markedly thereby 
Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex被引量：5
《Signal Transduction and Targeted Therapy》2023年第5期2392-2407,共16页Sihui Cai Chenqiu Zhang Zhen Zhuang Shengnan Zhang Ling Ma Shuai Yang Tao Zhou Zheyu Wang Weihong Xie Shouheng Jin Jincun Zhao Xiangdong Guan Jianfeng Wu Jun Cui Yaoxing Wu 
supported by the National Key R&D Program of China (2020YFA0908700);Guangdong Provincial Key R&D Program for Covid 19 (232020012620600001);National Natural Science Foundation of China (82025001,31970700,32170876);Guangdong Basic and Applied Basic Research Foundation (2020B1515120090);Natural Science Foundation of Guangdong Province,China (2021A1515012179);Guangdong Clinical Research Center for Critical Care Medicine (2020B1111170005);the Sun Yat‑sen University Clinical Research Program 5010 (2019002).
Currently,the incidence and fatality rate of SARS-CoV-2 remain continually high worldwide.COVID-19 patients infected with SARS-CoV-2 exhibited decreased type I interferon(IFN-I)signal,along with limited activation of ...
关键词：INTERFERON SEPARATED cGAS 
TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN
《Signal Transduction and Targeted Therapy》2023年第4期1814-1827,共14页Qiang Qiu Yuanyuan Sun Linyu Yang Qingqing Li Yunyu Feng Mengyuan Li Yuexia Yin Li Zheng Ning Li Huandi Qiu Xue Cui Wei He Bochuan Wang Cong Pan Zi Wang Juan Huang Klarke MSample Zhihui Li Yiguo Hu 
the State Key Laboratory of Biotherapy&Collaborative Innovation Center for Biotherapy for support;the staff of the core facility and the animal facility of the State Key Laboratory of Biotherapy and West China Hospital.This work was supported by grants from the National Natural Science Foundation of China(82200152,81770103);National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University(Z20201008);West China Hospital 1.3.5 Project for Disciplines of Excellence(ZYJC18025);Guizhou Provincial Science&Technology Support Program(NO[2020]4Y061);The Guizhou Innovation and Entrepreneurship Foundation for High-level Overseas Talent(NO.[2019]03).
We report herein that TSPAN32 is a key node factor for Philadelphia (Ph+) leukemia pathogenesis. We found that TSPAN32expression was repressed by BCR-ABL and ectopic TSPAN32 expression upon Imatinib treatment inhibite...
关键词：PATHOGENESIS IMPAIRED inhibited 
Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2被引量：4
《Signal Transduction and Targeted Therapy》2023年第4期1874-1888,共15页Penglei Wang Xuechao Jia Bingbing Lu Han Huang Jialin Liu Xuejiao Liu Qiong Wu Yamei Hu Pan Li Huifang Wei Tingting Liu Dengyun Zhao Lingwei Zhang Xueli Tian Yanan Jiang Yan Qiao Wenna Nie Xinli Ma Ruihua Bai Cong Peng Zigang Dong Kangdong Liu 
the National Natural Science Foundations of China(No.81872335);The Central Plains Science and Technology Innovation Leading Talents(No.224200510015);Program for Science&Technology Innovation Talents in Universities of Henan(No.20HASTIT048);the Cultivation Foundation of Zhengzhou University(No.JC202035022)。
Constitutive activation of RAS-RAF-MEK-ERK signaling pathway(MAPK pathway)frequently occurs in many cancers harboring RAS or RAF oncogenic mutations.Because of the paradoxical activation induced by a single use of BRA...
关键词：MEK1/2 BRAF ACTIVATION 
Promotion of liquid-to-solid phase transition of cGAS by Baicalein suppresses lung tumorigenesis被引量：2
《Signal Transduction and Targeted Therapy》2023年第4期1392-1395,共4页Tiansheng Zheng Haipeng Liu Yifan Hong Yajuan Cao Qing Xia Chengge Qin Ming Li Russel J.Reiter Yidong Bai Lihong Fan 
the National Natural Science Foundation of China(Nos.31770131,81473469 to L.F.and 81922030 to H.L.);International Cooperation Project of the Belt and Road(No.20400750600);Construction project of Shanghai TCM-intigrated innovative flagship hospital(ZY(2021-2023)-0205-05,ZXXT-202203);Shanghai Municipal Commission of Health and Family Plan(201840056);H.L.was sponsored by Shanghai Shuguang Program(20SG19).
Dear Editor,Kras and p53 mutation are among the most common gene mutations in lung cancer,which has both the highest incidence and mortality rate among cancers.1 Kras/p53 mutation also causes mitochondrial dysfunction...
关键词：LUNG BAICALEIN inhibited 
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1被引量：16
《Signal Transduction and Targeted Therapy》2023年第3期1159-1174,共16页Heng Xu Hongfang Zhao Chunyong Ding Defang Jiang Zijie Zhao Yang Li Xiaoyu Ding Jing Gao Hu Zhou Cheng Luo Guoqiang Chen Ao Zhang Ying Xu Hao Zhang 
We are grateful to National Centre for Protein Science Shanghai for their instrument support and technical assistance.We thank the staffs from BL19U1 beamline of National Facility for Protein Science Shanghai(NFPS)at Shanghai Synchrotron Radiation Facility,for assistance during data collection.We gratefully acknowledge the financial supports from the National Key Research and Development Program of China(2020YFE0202200 to H.Z.and 2021ZD0203900 to C.L.);the project of National Multidisciplinary Innovation Team of Traditional Chinese Medicine(ZYYCXTD-202004 to C.L.);the National Natural Science Foundation of China(81903538 to H.Z.,82104064 to H.X.,91853205 to C.L.,91853206 to G.C.,81773565 to A.Z.,81972615 to Y.X.,and 21877120,22177068 to C.D.);the Postdoctoral Research Foundation of China(2019M661673 to H.Z.);the Shanghai Sailing Plan(19YF1457200 to H.Z.);the grants from Shanghai Jiao Tong University(AF1700037,WF220217002,WH101117001,and WF540162618 to A.Z.).
As a terpenoids natural product isolated from the plant Thunder God Vine,Celastrol is widely studied for its pharmacological activities,including anti-tumor activities.The clinical application of Celastrol is strictly...
关键词：COLORECTAL cancer NUDE 
Metformin suppresses calcium oxalate crystal-induced kidney injury by promoting Sirt1 and M2 macrophage-mediated anti-inflammatory activation被引量：3
《Signal Transduction and Targeted Therapy》2023年第2期373-376,共4页Haoran Liu Chen Duan Xiaoqi Yang Jianhe Liu Yaoliang Deng Hans-Göran Tiselius Zhangqun Ye Tao Wang Jinchun Xing Hua Xu 
This work was supported by the National Natural Science Foundation of China(82070726,82060137,81970604,and 82100808);the Key Project of the Guangxi Natural Science Foundation(2020GXNSFDA297013);the China Postdoctoral Science Foundation(2021M690185);the Anhui Postdoctoral Science Foundation(2021A482);the Anhui Provincial Department of Education Research Project(KJ2020A0167).
Dear Editor,Kidney stones are one of the most common clinical diseases in urology.Approximately 80%of renal calculi are composed of calcium oxalate(CaOx)crystals,which are gradually deposited in the medullary collecti...
关键词：KIDNEY clinical DISEASES 
Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity被引量：1
《Signal Transduction and Targeted Therapy》2023年第2期795-812,共18页Bo Zhang Jiaqi Sun Yeshuang Yuan Dezhong Ji Yeting Sun Yudong Liu Shengjie Li Xingxing Zhu Xunyao Wu Jin Hu Qiu Xie Ling Wu Lulu Liu Boyang Cheng Yuanjie Zhang Lingjuan Jiang Lidan Zhao Fei Yu Wei Song Min Wang Yue Xu Shiliang Ma Yunyun Fei Lihe Zhang Demin Zhou Xuan Zhang 
This study was supported by grants from the National Key Research and Development Program of China(2019ZX09739);National Natural Science Foundation of China(82230060,82271831,81788101,82204258);Chinese Academy of Medical Science Innovation Fund for Medical Sciences(CIFMS,2021-I2M-1-016,2021-I2M-1-017,2021-I2M-1-047,2021-I2M-1-040,2021-I2M-1-016,2021-I2M-1-026);Natural Science Foundation of Beijing(7222263);Beijing Capital Health Development Fund(2020-2-4019);Fundamental Research Funds for the Central Universities(3332022108).
Interleukin-2(IL-2)is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells(Tregs)and effector cells,leading to paradoxical consequences.Here,we report a strategy that exploite...
关键词：SUSTAINED PROXIMITY consequences 
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