URINE

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A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options被引量：2
《Science China(Life Sciences)》2022年第9期1866-1880,共15页Yuntao Liu Lan Song Nairen Zheng Jinwen Shi Hongxing Wu Xing Yang Nianci Xue Xing Chen Yimin Li Changqing Sun Cha Chen Lijuan Tang Xiaotian Ni Yi Wang Yaling Shi Jianwen Guo Guangshun Wang Zhongde Zhang Jun Qin 
This work was supported by the National Key Research and Development Program of China(2017YFA0505102,2017YFA0505103,2017YFA0505104,2017YFC0908404,2018YFA0507503,2020YFA0708001);the National Natural Science Foundation of China(81874237,31870828);Major National Science and technology projects(2017ZX10305501-006);National Administration of Traditional Chinese Medicine:2019 Project of Building Evidence Based Practice Capacity for TCM(2019XZZX-LG003);Guangdong Key-Area Research and Development Program(2019B020229002,2020B1111300005);Guangzhou Science and Technology Program(201902020009);Guangdong Provincial Key Laboratory of Research on Emergency in TCM(2017B030314176).
Signaling pathway alterations in COVID-19 of living humans as well as therapeutic targets of the host proteins are not clear.We analyzed 317 urine proteomes,including 86 COVID-19,55 pneumonia and 176 healthy controls,...
关键词：COVID-19 URINE PROTEOME CLYBL itaconate 
Comparative study on virus shedding patterns in nasopharyngeal and fecal specimens of COVID-19 patients被引量：6
《Science China(Life Sciences)》2021年第3期486-488,共3页Ning Zhang Yuhuan Gong Fanping Meng Yi Shi Jun Wang Panyong Mao Xia Chuai Yuhai Bi Penghui Yang Fusheng Wang 
the Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDB29010102 and XDA19090118);the National Natural Science Foundation of China(NSFC)(32041010);Hebei Key Research and Development Program(20277704D);Y.B.is supported by the NSFC Outstanding Young Scholars(31822055);Youth Innovation Promotion Association of CAS(2017122).
Dear Editor,An acute viral pneumonia(COVID-19),caused by the novel coronavirus known as SARS-CoV-2,was first identified during December 2019 in China(Zhu et al.,2020).SARSCoV-2 was found to be highly transmissible in ...
关键词：PATIENTS diagnosis URINE 
Predicative value of urinary protein biomarkers on delayed renal involvement in children with Henoch-Sch?nlein purpura
《Science China(Life Sciences)》2019年第12期1594-1596,共3页Haipeng Liu Wei Cui Hongjuan Liu Chenyu Zhang 
supported by the Key Research and Development Program Projects in Anhui, China (1704a0802172)
Dear Editor,Henoch-Schonlein purpura(HSP)is one of the most common vasculitides in children with the incidence of 10-30 cases per 100,000 per year(Chen and Mao,2015)and its prognosis primarily depends on the extent of...
关键词：INVOLVEMENT URINARY URINE 
Profiling of lysine-acetylated proteins in human urine被引量：2
《Science China(Life Sciences)》2019年第11期1514-1520,共7页Weiwei Qin Ting Wang He Huang Youhe Gao 
supported by the National Key Research and Development Program of China(2018YFC0910202,2016YFC1306300);the Beijing Natural Science Foundation(7172076);the Beijing cooperative construction project(110651103);the Beijing Normal University(11100704);the Peking Union Medical College Hospital(2016-2.27)
A biomarker is a measurable indicator associated with changes in physiological state or disease.In contrast to the blood which is under homeostatic controls,urine reflects changes in the body earlier and more sensitiv...
关键词：URINE POST-TRANSLATIONAL modification LYSINE ACETYLATION 
Early urinary candidate biomarker discovery in a rat thioacetamide-induced liver fibrosis model被引量：3
《Science China(Life Sciences)》2018年第11期1369-1381,共13页Fanshuang Zhang Yanying Ni Yuan Yuan Wei Yin Youhe Gao 
supported by the National Key Research and Development Program of China (2016YFC1306300);the National Basic Research Program of China (2013CB530850), Beijing Natural Science Foundation (7173264, 7172076);Funds from Beijing Normal University (11100704, 10300-310421102)
Biomarker is the change associated with the disease. Blood is relatively stable because of the homeostatic mechanisms of the body. However, urine accumulates changes of the body, which makes it a better early biomarke...
关键词：URINE proteomics biomarker animal MODEL liver FIBROSIS 
Early candidate biomarkers found from urine of glioblastoma multiforme rat before changes in MRI被引量：4
《Science China(Life Sciences)》2018年第8期982-987,共6页Yanying Ni Fanshuang Zhang Manxia An Wei Yin Youhe Gao 
Dear Editor, Gliomas are the most frequent primary tumors of the central nervous system, accounting for more than 60% of all brain tumors （Wang and Bettegowda, 2015）. Among them, glio-blastoma multiforme （GBM） is ...
关键词：候选人 MRI 老鼠 神经系统 放射疗法 脑肿瘤 尿 治疗学 
Changes of proteins induced by anticoagulants can be more sensitively detected in urine than in plasma被引量：19
《Science China(Life Sciences)》2014年第7期649-656,共8页LI MengLin ZHAO MinDi GAO YouHe 
supported by the National Basic Research Program of China (2012CB517606,2013CB530805);Expertise-Introduction Project for Disciplinary Innovation of Universities (B08007);National Natural Science Foundation of China (31200614);Beijing Natural Science Foundation (5132028)
The most fundamental property of biomarkers is change.But changes are hard to maintain in plasma since it is strictly controlled by homeostatic mechanisms of the body.There is no homeostatic mechanism for urine.Beside...
关键词：biomarker HOMEOSTASIS URINE PLASMA PROTEOMICS 
Urine—an untapped goldmine for biomarker discovery?被引量：32
《Science China(Life Sciences)》2013年第12期1145-1146,共2页GAO YouHe 
The past decade witnessed a few biomarkers discovered and validated;however,biomarker research as a whole has not been fruitful as expected.A majority of our efforts has been focused on blood,the dynamic tissue direct...
关键词：生物标志物 金矿 开发 动态组织 临床价值 尿 
Applications of urinary proteomics in biomarker discovery被引量：16
《Science China(Life Sciences)》2011年第5期409-417,共9页SHAO Chen WANG Yan GAO YouHe 
Urine is an important source of biomarkers. This article reviews current advances, major challenges, and future prospects in the field of urinary proteorrfics. Because the practical clinical problem is to distinguish ...
关键词：URINE PROTEOMICS BIOMARKER 
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