HOMEOSTASIS

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Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation被引量：5
《Signal Transduction and Targeted Therapy》2023年第2期730-743,共14页Zhaoyuan Fang Xiangkun Han Yueqing Chen Xinyuan Tong Yun Xue Shun Yao Shijie Tang Yunjian Pan Yihua Sun Xue Wang Yujuan Jin Haiquan Chen Liang Hu Lijian Hui Lin Li Luonan Chen Hongbin Ji 
We thank Drs.Tyler Jacks,Ronald A.DePinho,Kwok-kin Wong,and Lijian Hui for the generous gift of various mouse strains.We also thank Ruiqi Wang,Rui Liu,Pei Chen,Chao Zheng,and Jifan Shi for helpful discussion.This work was supported by the National Basic Research Program of China(Nos.2017YFA0505500 to H.J.and L.C.,2020YFA0803300 to H.J.);the National Natural Science Foundation of China(Nos.91731314,82030083,31621003,81872312,82011540007 to H.J.,12131020,31930022,12026608 to L.C.,82273093 to Z.F.,81871875,82173340 to L.H.,81802279 to H.H.,81902326 to X.W.,81402371 to Y.J.);the Strategic Priority Research Program of the Chinese Academy of Sciences(Nos.XDB19020201 to H.J.,XDB38040400 to L.C.);Basic Frontier Scientific Research Program of Chinese Academy of Science(No.ZDBS-LY-SM006 to H.J.);International Cooperation Project of Chinese Academy of Sciences(No.153D31KYSB20190035 to H.J.);the Science and Technology Commission of Shanghai Municipality(No.21ZR1470300 to L.H.);the Youth Innovation Promotion Association CAS(No.Y919S31371 to X.W.);Special Fund for Science and Technology Innovation Strategy of Guangdong Province(Nos.2021B0909050004,2021B0909060002 to L.C.);Major Key Project of PCL(No.PCL2021A12 to L.C.);JST Moonshot R&D Project(No.JPMJMS2021 to L.C.).
Lkb1 deficiency confers the Kras-mutant lung cancer with strong plasticity and the potential for adeno-to-squamous transdifferentiation(AST).However,it remains largely unknown how Lkb1 deficiency dynamically regulates...
关键词：SQUAMOUS HOMEOSTASIS LUNG 
miR398b negatively regulates cotton immune responses to Verticillium dahliae via multiple targets
《The Crop Journal》2022年第4期1026-1036,共11页Yuhuan Miao Kun Chen Jinwu Deng Lin Zhang Weiran Wang Jie Kong Steven J.Klosterman Xianlong Zhang Alifu Aierxi Longfu Zhu 
supported by the National Key Research and Development Program of China(2018YFD0100403);the project from the Ministry of Science and Technology of China(KY201702009).
MicroRNAs(miRNAs)play essential roles in plant defense responses,although such roles have not been identified in cotton in response to the plant pathogenic fungus Verticillium dahliae.In this study,the functions of mi...
关键词：COTTON miR398b NBS-LRR ROS homeostasis Verticillium dahliae 
Novel pyroptosis-independent functions of gasdermins
《Signal Transduction and Targeted Therapy》2022年第5期1366-1368,共3页Ziran Qin Fangfang Zhou Long Zhang 
This work was supported by a special program from the Ministry of Science and Technology of China(2021YFA101000);the Chinese National Natural Science Funds(U20A20393,U20A201376,31925013,3212500161,82041009,31871405,31701234,81902947,82041009,31671457,31571460,and 91753139);Jiangsu Provincial Distinguished Young Scholars award(BK20180043);the Key Project of University Natural Science Foundation of Jiangsu Province(19KJA550003);A project Funded by the Priority Acadamic Program Development of Jiangsu Higher Education Institutions and the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX17_2036).
Recently,Rana et al.and Zhang et al.published two studies illustrating the important regulatory roles of gasdermin B(GSDMB)and-D(GSDMD)in inflammatory bowel disease(IBD)and intestinal immune homeostasis maintenance,re...
关键词：HOMEOSTASIS COLLECTIVE 
A pair of transporters controls mitochondrial Zn^(2+) levels to maintain mitochondrial homeostasis被引量：3
《Protein & Cell》2022年第3期180-202,共23页Tengfei Ma Liyuan Zhao Jie Zhang Ruofeng Tang Xin Wang Nan Liu Qian Zhang Fengyang Wang Meijiao Li Qian Shan Yang Yang Qiuyuan Yin Limei Yang Qiwen Gan Chonglin Yang 
This work was supported by grants from the National Science Foundation of China(91954204 and 31730053);the National Basic Research Program of China(2017YFA0503403);Yunnan Province Science and Technology Department(#202001BB050077 and#202105AB160003).
Zn^(2+)is required for the activity of many mitochondrial proteins,which regulate mitochondrial dynamics,apoptosis and mitophagy.However,it is not understood how the proper mitochondrial Zn^(2+)level is achieved to ma...
关键词：mitochondria Zn^(2+)transporter C.elegans ER-mitochondrial contact development 
Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA被引量：5
《Cellular & Molecular Immunology》2021年第6期1412-1424,共13页Benyu Liu Nian Liu Xiaoxiao Zhu Liuliu Yang Buqing Ye Huimu Li Pingping Zhu Tiankun Lu Yong Tian Zusen Fan 
supported by the Ministry of Science and Technology of China(2020YFA0803501 and 2019YFA0508501);the National Natural Science Foundation of China⑶930036,81921003,92042302,31870883,91940305,31728006,81772646,and 31871494);the Strategic Priority Research Programs of the Chinese Academy of Sciences(XDB19030203);the Beijing Natural Science Foundation(5192018);the Biological Resource Program of the Chinese Academy of Science(KFJ-BRP-017-04);the Young Elite Scientist Sponsorship Program of CAST(2018QNRC001).
Group 3 innate lymphoid cells(ILC3s)play critical roles in innate immunity and gut homeostasis.However,how ILC3 homeostasis is regulated remains elusive.Here,we identified a novel circular RNA,circZbtb20,that is highl...
关键词：circZbtb20 ILC3 Alkbh5 Nr4a1 HOMEOSTASIS 
ROS is essential for initiation of energy deprivation-induced autophagy被引量：2
《Journal of Genetics and Genomics》2021年第6期512-515,共4页Choufei Wu Yixing Li Shu Zhong Yingcong Chen Yu Xie Yuyao Feng Weijing Yao Suping Fu Yanlan Zhu Liefeng Wang Yuting Chen Liqin Zhang Jingjing Tong Cong Yi 
supported by the National Natural Science Foundation of China(32070739,31771528,and 91754107);Zhejiang Provincial Natural Science Foundation of China(LR21C070001);the National Basic Research Program of China(2017YFA0503402)to C.Yi;Natural Science Foundation for Young Scientists of China(81800085);Natural Science Foundation of Hubei Province,China(ZRMS2020002147)to J.Tong;Zhejiang Key R&D Program of China(2019C02030)to L.Zhang。
Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(...
关键词：DEPRIVATION HOMEOSTASIS 
Emerging relationship between RNA helicases and autophagy
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2020年第10期767-778,共12页Miao-miao ZHAO Ru-sha WANG Yan-lin ZHOU Zheng-gang YANG 
State S&T Project of 13th Five Year of China(No.2018ZX10302206);the National Basic Research Program(973)of China(No.2017YFA0503402);the Independent Project Fund of the State Key Laboratory for Diagnosis and Treatment of Infectious Disease,Hangzhou,China。
RNA helicases,the largest family of proteins that participate in RNA metabolism,stabilize the intracellular environment through various processes,such as translation and pre-RNA splicing.These proteins are also involv...
关键词：RNA helicase AUTOPHAGY HOMEOSTASIS REGULATION 
Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditis elegans被引量：3
《Journal of Genetics and Genomics》2020年第3期145-156,共12页Ruofeng Tang Xin Wang Junxiang Zhou Fengxia Zhang Shan Zhao Qiwen Gan Liyuan Zhao Fengyang Wang Qian Zhang Jie Zhang Guodong Wang Chonglin Yang 
supported by grants from the National Scicnce Foundation of China(91954204 and 31730053);the National Basic Research Program of China(2017YFA0503403)。
Arginine catabolism involves enzyme-dependent reactions in both mitochondria and the cytosol,defects in which may lead to hyperargininemia,a devastating developmental disorder.It is largely unknown if defective argini...
关键词：ARGININE ARGINASE Hyperargininemia Mitochondrial homeostasis C.elegans 
ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice被引量：4
《Cellular & Molecular Immunology》2020年第2期163-177,共15页Tian Deng Caixia Suo Jiali Chang Rui Yang Jingyu Li Ting Cai Ju Qiu 
This study was supported by grants 2015CB943400 and 2014CB943300 from the Ministry of Science and Technology of China;grant XDB19000000 from the“Strategic priority research program of the Chinese Academy of Sciences”;grants 91542102 and 31570887 from the National Natural Science Foundation of China;China's Youth 1000 Talent Program to Q.J.
OX40L is one of the co-stimulatory molecules that can be expressed by splenic lymphoid tissue inducer(Lti)cells,a subset of group 3 innate lymphoid cells(ILC3s).OX40L expression in subsets of intestinal ILC3s and the ...
关键词：Group 3 innate lymphoid cells OX40L Regulatory T cells Intestinal immunity 
Targeting NF-κB pathway for the therapy of diseases:mechanism and clinical study被引量：215
《Signal Transduction and Targeted Therapy》2020年第1期749-771,共23页Hui Yu Liangbin Lin Zhiqiang Zhang Huiyuan Zhang Hongbo Hu 
supported by the Ministry of Science and Technology of China(the National Key Research and Development Program 2016YFA0502203,2019YFA0110201,and 2019YFA0110203);the National Natural Science Foundation of China(91740111,81871232,and 31870881),1.3.5 Project of disciplines of excellence and National Clinical Research Center for Geriatrics(Z2020001),West China Hospital,Sichuan University.
NF-κB pathway consists of canonical and non-canonical pathways.The canonical NF-κB is activated by various stimuli,transducing a quick but transient transcriptional activity,to regulate the expression of various pro...
关键词：DISEASES HOMEOSTASIS INFLAMMATION 
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