SYNAPTIC

作品数：319被引量：717H指数：13
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Ibrutinib alleviated LPS-induced neuroinflam⁃mation and synaptic defects in mouse model of depression被引量：17
《中国药理学与毒理学杂志》2021年第9期684-685,共2页LI Wei-fen Tahir Ali HE Kai-wu LIU Zi-zhen Fawad Ali Shah REN Qing-guo LIU Yan JIANG An-long LI Shu-peng 
OBJECTIVE Previous studies have demonstrated a close association between an altered immune system and major depressive disorders,and inhibition of neuroinflammation may represent an alternative mechanism to treat depr...
关键词：ibrutinib NEUROINFLAMMATION depres⁃sion synaptic defects 
Activation of α7 nAChR by PNU improves synaptic and cognitive function through restoring the expression of synaptic-associated proteins
《中国药理学与毒理学杂志》2019年第6期474-475,共2页WANG Xiao-lin DENG Yu-xin GAO Yu-mei DONG Yang-ting WANG Fan GUAN Zhi-zhong HONG Wei QI Xiao-lan 
OBJECTIVE Alzheimer disease(AD) is the most common type of dementia and is featured by the accumulation of β-amyloid peptide(Aβ) in the brain. The Alpha 7 nicotinic acetylcholine receptor family(α7 nAChR) was widel...
关键词：α7 NACHR Β-AMYLOID peptide SYNAPTIC CaM-CaMKⅡ-CREB signalling pathway ALZHEIMER disease 
Active fraction combination from Liuwei Dihuang decoction(LW-AFC) ameliorates corticosterone-induced long-term potentiation impairment in mice in vivo被引量：4
《中国药理学与毒理学杂志》2019年第6期436-437,共2页HUANG Yan LI Dong CHENG Bin LIU Gang ZHANG Yong-xiang ZHOU Wen-xia 
Liuwei Dihuang decoction(LW), a classic formula in traditional Chinese medicine(TCM), has been used for nearly one thousand years for various diseases with characteristic features of kidney yin deficiency. LW consists...
关键词：LW-active fraction COMBINATION ACTIVE FRACTIONS CORTICOSTERONE long-term POTENTIATION SYNAPTIC plasticity stress 
Role and mechanisms underlying tau accumulation-induced neurodegeneration and synapse impairment
《中国药理学与毒理学杂志》2019年第6期401-402,共2页WANG Jian-zhi 
As a structural protein, the physiological function of tau proteins is to promote microtu-bule assembly and maintain the stability of the microtubules, so that to build up the tracks for axonal transport of the neuron...
关键词：TAU ACCUMULATION SYNAPTIC plasticity NMDA receptors 
Modulating balance of synaptic and extrasynaptic NMDA receptors as strategy for Alzheimer disease drug discovery
《中国药理学与毒理学杂志》2019年第6期404-404,共1页ZHOU Wen-xia 
The unbalance between synaptic(Glu N2 A, mediating the protective pathway) and extrasynaptic NMDA receptors(NMDARs)(Glu N2 B, mediating the excitotoxic pathway) has been found in Alzheimer disease(AD), indicating rest...
关键词：Alzheimer disease GLU N2A GLU N2B IFENPRODIL D-CYCLOSERINE drug discovery 
Impairment of LTP in insular cortex is correlated to resilience and vulnerability to chronic stress for PTSD
《中国药理学与毒理学杂志》2018年第9期727-728,共2页JIA Jing-jing SHI Tian-yao ZHOU Wen-xia 
National Natural Science Foundation of China(81402912).
OBJECTIVE Exposure to stressful events can be differently perceived by individuals depending on the level of stress resilience or vulnerability.The neural processes that underlie such clinical y and social y important...
关键词：LTP insular cortex SYNAPTIC plasticity PTSD RESILIENCE VULNERABILITY 
Diazepam reduces synaptic GABA type areceptor availability via multiple trafficking mechanisms
《中国药理学与毒理学杂志》2017年第10期952-952,共1页Joshua M LORENZ-GUERTIN Sabyasachi DAS Tija C JACOB 
supported by National Institute of Health(T32GM008424);Whitehall Foundation;William C DEGROAT Neuropharmacology Departmental Fellowship;Pharmacology and Chemical Biology Startup Funds
OBJECTIVE Investigate the effects of diazepam(DZP) on γ2 subunit containing GABA type A receptor(GABA A R) trafficking.METHODS Immunofluorescence microscopy measured surface GABA A Rs and gephyrin in rat cortical neu...
关键词：GABA type A receptor GEPHYRIN TRAFFICKING DIAZEPAM 
运动皮质的塑性:多巴胺的神经分布(英文)被引量：1
《中国药理学与毒理学杂志》2016年第10期1001-1002,共2页YUNG Wing-Ho 
The project supported by NSFC grant(SZRIA0314025);SRFDP-HKRGC grant(2900703);HKGRF grant(2140903);HMRF grant(02130976)
The motor cortex plays a key role in motor control as its output directly generates movement.However,it is known that the motor cortex also exhibits a high degree of plasticity that may be important in both health and...
关键词：plasticity cortex SYNAPTIC 神经分布 neuronal CONSCIOUS 运动皮质 administration ALIGNED DOPAMINE 
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