supported by the National Natural Science Foundation of China(22361003,82260676);Talent Project of Jiangxi Province(jxsq2019101065);the Jiangxi Provincial Natural Science Foundation(20224BAB216005,20232BAB216131);the Science and Technology Projects of Ganzhou(202101094462,2023PNS26854);The Start-up Fund of Gannan Medical University.
Herein,an unprecedented nickel-catalyzed regioselective hydroalkynylation of unsymmetrical internal alkynes was realized with steric hindered resistance selectivity via the cyano-directing group strategy.Significantly...
the National Natural Science Foundation of China(No.22271245)for the financial support;the Yantai“Double Hundred Plan”;the Talent Induction Program for Youth Innovation Teams in Colleges and Universities of Shan-dong Province。
A new 1,4-amidocyanation of 1,3-enynes with N-amidopyridin-1-ium salts and TMSCN using a copper and photoredox synergetic catalysis for producingα-amido allenyl nitriles is developed.Employing N-amidopyridin-1-ium sa...
supported by the National Natural Science Foundation of China(Nos.22301256 and 22271244);the Hunan Provincial Natural Science Foundation of China(2023JJ40618);the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(2022c02);the Hunan Provincial Innovation Foundation for Postgraduate(CX20230644,XDCX2023Y162)
A general and broadly applicable copper and photoredox dual-catalyzed multicomponent 1,4-perfluoroalkylcyanation of 1,3-enynes has been developed.This protocol enjoys success with high regioselectivity,mild reaction c...
support from the National Natural Science Foundation of China(Nos.21971107,22071101,22271147).
This work describes intermolecular acylfluorination of gem-difluoroenynes using acyl fluorides as both acyl source and fluorine source.Trifluoromethyl-substituted allenones or furans could be selectively achieved via ...
supported by the National Natural Science Foundation of China(22171220,21971201);the Fundamental Research Funds of the Central Universities(xtr072022003)。
An efficient Ni-catalyzed four-component 1,4-carbocarbonylation of 1,3-enynes with activated alkyl halides and arylboronic acids under atmospheric pressure of CO is presented.By tuning the electronic and steric effect...
supported by the National Natural Science Foundation of China(NSFC,Nos.22001251,21922112,and 22225107);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000);National Key R&D Program of China(No.2017YFA0700103);the Guizhou Provincial S&T Project(No.2018[4007]).
Borylation of 1,3-enynes with bis(boronate)compounds often ends up with the formation of hydroborylated products,leaving the diborylation of 1,3-enynes for the formation of 1,4-diborylated allenes to be challenging.He...
supported by Tianjin University(B22021-010);the State Key Laboratory of Elemento-Organic Chemistry;the National Natural Science Foundation of China(22371203,22073066,21503143,21975179)。
The Ni-catalyzed highly selective diborylative cyclization of 1,6-enynes with diboron reagent has been developed. When pinB-Bdan was used, multiple types of boron-containing functional groups could be installed into o...
We are grateful for the financial support from the National Natural Science Foundation of China(NSFC,No.22071262);the Science and Technology Commission of Shanghai Municipality(No.22ZR1475200);Shanghai Rising-Star program(No.20QA1411300).
1,4-Enyne units are ubiquitous skeletons in biologically active molecules and natural products.Especially,they represent versatile building blocks for abundant downstream derivatizations via controllable modifications...
Financial support from Dalian Outstanding Young Scientific Talent(No.2020RJ05);the National Natural Science Foundation of China(Nos.22071239,21971234)。
A regiodivergent hydrophosphorylation of enynes with phosphites has been developed using earthabundant nickel catalyst.The manipulation of regioselectivity can be achieved by regulating the insertion order of alkyne b...
supported by the National Natural Science Foundation of China(Nos.22171240 and 21861042);the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT17R94);China Postdoctoral Science Foundation(No.2020M712707)。
In recent years,the concept of transition metal-catalyzed functionalization of unsaturated hydrocarbons has emerged as a promising strategy for developing new and valuable reactions,and has attracted considerable atte...