MIMETICS

作品数：33被引量：68H指数：4
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相关领域：医药卫生理学更多>>
相关作者：赵盼蔡超凡飞高蕾于广利更多>>
相关机构：中国人民解放军中国海洋大学大连理工大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《The Innovation》《Medicine in Novel Technology and Devices》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金SA-SIBS优秀人才奖励基金更多>>
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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease
《Neural Regeneration Research》2025年第4期1094-1095,共2页Natalia Kulesskaya Kira M.Holmström Henri J.Huttunen 
supported by Herantis Pharma Plc and the European Innovation Council(grant acronym ReTreatPD).
Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying treatments.While for decades there have been various...
关键词：DISEASES treatment THERAPEUTIC 
Nano-crystallites Imine-based Copper(II) Complexes as Mimetics for Copper Oxidase Proteins: Synthesis,Characterization,DFT and Oxidase Mimicking Activity
《Chemical Research in Chinese Universities》2024年第6期1068-1081,共14页ALHADHRAMI Abdulrahman RAMADAN Abd El-Motaleb FATHY Ahmed 
the Deanship of Graduate Studies and Scientific Research,Taif University for funding this work.
Three tridentate imine ligands containing N2S donors were synthesized via Schiff condensation between derivatives of both amino triazine and 2-carbonyl pyridine.The reaction of these ligands with CuCl2 in a molar rati...
关键词：Nano-crystallite Imine-based copper(II)complex Mimetics of copper oxidase protein Synthesis and characterization Density function theory(DFT)calculation 
Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS被引量：4
《Acta Pharmaceutica Sinica B》2024年第5期2039-2056,共18页Pei Yu Yubao Han Lulu Meng Yanyuan Tian Zhiwei Jin Jun Luo Chao Han Wenjun Xu Lingyi Kong Chao Zhang 
This research received funding from the National Natural Science Foundation of China(Grant Nos.:82274073,82304713,and 81872986);was supported by the Jiangsu Provincial Excellent Postdoctoral Program(Grant Numbers:2022ZB291,China).
Osteosarcoma,a prevalent primary malignant bone tumor,often presents with lung metastases,severely impacting patient survival rates.Extracellular vesicles,particularly exosomes,play a pivotal role in the formation and...
关键词：Lung–bone transmission miR-194/215 cluster EXOSOME Lung metastasis Epithelial–mesenchymal transition Vasculogenic mimicry Bioengineered exosome mimetics OSTEOSARCOMA 
Can exercise benefits be harnessed with drugs?A new way to combat neurodegenerative diseases by boosting neurogenesis
《Translational Neurodegeneration》2024年第1期575-602,共28页Renqing Zhao 
Adult hippocampal neurogenesis(AHN)is affected by multiple factors,such as enriched environment,exercise,ageing,and neurodegenerative disorders.Neurodegenerative disorders can impair AHN,leading to progressive neurona...
关键词：Exercise mimetics Neurological diseases NEUROGENESIS COGNITION 
Biofabrication methods for reconstructing extracellular matrix mimetics被引量：3
《Bioactive Materials》2024年第1期475-496,共22页Abdellah Aazmi Duo Zhang Corrado Mazzaglia Mengfei Yu Zhen Wang Huayong Yang Yan Yan Shery Huang Liang Ma 
funding from National Key Research and Development Program of China(No.2018YFA0703000);The National Natural Science Foundation of China No.52275294 and supports from Zhejiang University Global Partnership Fund;the financial support from Chinese Scholar Councils(CSC)Scholarship fund.We would also like to thank Dr.Zhaoying Li and Dr.Elisabeth Lauren Gill for their essential contributions.
In the human body,almost all cells interact with extracellular matrices(ECMs),which have tissue and organ-specific compositions and architectures.These ECMs not only function as cellular scaffolds,providing structural...
关键词：Extracellular matrix BIOFABRICATION Electrospinning BIOPRINTING Organ-on-a-Chip 
High density lipoprotein as a therapeutic target:Focus on its functionality
《BIOCELL》2023年第11期2361-2383,共23页LEONARDO GÓMEZ ROSSO BELÉN DAVICO EZEQUIEL LOZANO CHIAPPE WALTER TETZLAFF LAURA BOERO FERNANDO BRITES MAXIMILIANO MARTÍN 
Cardiovascular diseases(CVDs)are the leading cause of death globally.CVDs are a group of disorders of the heart and blood vessels and include coronary heart disease,cerebrovascular disease and rheumatic heart disease ...
关键词：HDL Cholesterol efflux rHDL Apo A-I mimetics STATINS PARAOXONASE 
Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing被引量：3
《Acta Pharmaceutica Sinica B》2023年第5期1887-1902,共16页Yub Raj Neupane Harish K.Handral Syed Abdullah Alkaff Wei Heng Chng Gopalakrishnan Venkatesan Chenyuan Huang Choon Keong Lee Jiong-Wei Wang Gopu Sriram Rhonnie Austria Dienzo Wen Feng Lu Yusuf Ali Bertrand Czarny Giorgia Pastorin 
the National University of Singapore(Nano Nash Program A-0004336-00-00&A-000850400-00,Singapore);Nanyang Technological University,Singapore(grant number 001487-00001);the Industry Alignment Fund—Pre-Positioning(IAF-PP)grant(A20G1a0046 and R-148-000-307-305/A0004345-00-00);the Singapore Ministry of Education,under its Singapore Ministry of Education Academic Research Fund Tier 1(10051-MOE AcRF Tier 1:Thematic Call 2020)from Bertrand Czarny;the National University of Singapore Nano-NASH Program(NUHSRO/2020/002/Nano Nash/LOA);the National University of Singapore Yong Loo Lin School of Medicine Nanomedicine Translational Research Program(NUHSRO/2021/034/TRP/09/Nanomedicine);the financial supports from Agency for Science,Technology,and Research(A~*STAR,Singapore)Advanced Manufacturing and Engineering Individual Research Grant(AME IRG)(Project ID:A1883c0013,Singapore)。
Wound healing is a dynamic process that involves a series of molecular and cellular events aimed at replacing devitalized and missing cellular components and/or tissue layers.Recently,extracellular vesicles(EVs),natur...
关键词：Extracellular vesicles Cell-derived nanovesicles BIONANOTECHNOLOGY Mesenchymal stem cells Fibroblasts Cell proliferation Cell migration ECM Wound healing 
Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing被引量：1
《Synthetic and Systems Biotechnology》2023年第1期11-19,共9页Lan Jiang Tianji Zhang Hongzhong Lu Saijuan Li Kangjie Lv Alex Tuffour Lixin Zhang Kan Ding Jin-Ping Li Hongmei Li Xueting Liu 
support from the National Key Research and Development Program of China (2021YFF0600700,2020YFA090032 and 2019YFA0906201);the Swedish research council (2020-05759);the National Natural Science Foundation of China (31720103901,31961133004,21907031,21977029,22108266).
The COVID-19 pandemic has caused severe health problems worldwide and unprecedented decimation of the global economy.Moreover,after more than 2 years,many populations are still under pressure of infection.Thus,a broad...
关键词：HEPARIN BIOSYNTHESIS Biological activities Bio-production 
Bio-inspired vision mimetics toward next-generation collision-avoidance automation被引量：1
《The Innovation》2023年第1期24-25,共2页Gary J.W.Xu Kun Guo Seop Hyeong Park Poly Z.H.Sun Aiguo Song 
supported in part by the EU’s Seventh Framework Program(EU FP7)International Research Staff Exchange Scheme(IRSES)Project-Towards zero road Accidents—Nature Inspired Hazard Perception under grant 318907;the Zhejiang Provincial Natural Science Foundation under grant LY23F030001.
MOTIVATION The current“deep learning+large-scale data+strong supervised labeling”technology framework of collision avoidance for ground robots and aerial drones is becoming saturated.Its development gradually faces ...
关键词：COLLISION driving integrating 
Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences被引量：4
《Military Medical Research》2023年第1期113-133,共21页Lei Pang Xi Jiang Xin Lian Jie Chen Er-Fei Song Lei-Gang Jin Zheng-Yuan Xia Hai-Chun Ma Yin Cai 
supported by grants from the National Natural Science Foundation of China(81800245,81970228,82102306,81900779);the China Postdoctoral Science Foundation(2020M670030ZX);the Shaoguan Science and Technology Program(2019sn078);the Start-up Fund for RAPs under the Strategic Hiring Scheme(P0035913)。
The literature is full of claims regarding the consumption of polyphenol or polyamine-rich foods that offer some protection from developing cardiovascular disease(CVD). This is achieved by preventing cardiac hypertrop...
关键词：Cardiovascular disease Cardiac aging Caloric restriction Gender difference Caloric restriction-mimetics Dietary compounds Clinical application 
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