METHYLCYTOSINE

作品数：48被引量：224H指数：7
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相关作者：黄京飞王莹刘次全柳维波贺新义更多>>
相关机构：北京林业大学中国科学院武汉大学上海交通大学更多>>
相关期刊：《Chinese Medical Journal》《Signal Transduction and Targeted Therapy》《American Journal of Molecular Biology》《Horticulture Research》更多>>
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RNA 5-Methylcytosine Modification:Regulatory Molecules,Biological Functions,and Human Diseases
《Genomics, Proteomics & Bioinformatics》2024年第5期11-26,共16页Yanfang Lu Liu Yang Qi Feng Yong Liu Xiaohui Sun Dongwei Liu Long Qiao Zhangsuo Liu 
supported by grants from the China Postdoctoral Science Foundation(Grant No.2021TQ0297);the Key Scientific Research Projects of Higher Education Institutions in Henan Province(Grant No.22A320060);the Henan Provincial Natural Science Foundation(Grant No.242300421479);the Henan Provincial Medical Science and Technology Research Projectt(Grant No.LHGJ20190115),China。
RNA methylation modifications influence gene expression,and disruptions of these processes are often associated with various human diseases.The common RNA methylation modification 5-methylcytosine(m^(5)C),which is dyn...
关键词：Biological process Human disease RNA methylation m^(5)C m^(5)C regulator 
NSUN2 mediates distinct pathways to regulate enterovirus 71 replication被引量：1
《Virologica Sinica》2024年第4期574-586,共13页Lishi Liu Zhen Chen Kui Zhang Haojie Hao Li Ma Haizhou Liu Baocheng Yu Shuang Ding Xueyan Zhang Miao Zhu Xiang Guo Yi Liu Haibin Liu Fang Huang Ke Peng Wuxiang Guan 
supported by the National Natural Science Foundation of China(31970168);the Key R&D Program of Hubei Province(2021BCD004);the Hubei Central Leading Local Science and Technology Special Project(2022BGE245);the Hubei Science and Technology Major Project[2021ACB004];the Wuhan Knowledge Innovation Special Project(2023020201020303).
Increasing evidences suggest that the methyltransferase NSUN2 catalyzes 5-methylcytosine(m5C)modifications on viral RNAs,which are essential for the replication of various viruses.Despite the function of m5C depositio...
关键词：NSUN2 5-methylcytosine Enterovirus 71 UBIQUITINATION PATHOGENICITY 
Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF)
《Oncology Research》2024年第3期503-515,共13页XING YE ZHOUTING TUO KAI CHEN RUICHENG WU JIE WANG QINGXIN YU LUXIA YE AKIRA MIYAMOTO KOO HAN YOO CHI ZHANG WURAN WEI DENGXIONG LI DECHAO FENG 
the Chinese Scholarship Council(Grant No.202206240086);the National Natural Science Foundation of China(Grant No.82170432);programs from Science and Technology Department of Sichuan Province(Grant No.2020YFSY0024).
The incre asing interest in RNA modifications has signifcantly advanced epigenomic and epitranscriptomic technologies.This study focuses on the immuno oncological impact of ALYREF in human cancer through a pan-cancer ...
关键词：Pan-cancer RNA 5-methylcytosine ALYREF Immwno-oncological efects 
Tet methylcytosine dioxygenase 2(TET2)deficiency elicits EGFR-TKI(tyrosine kinase inhibitors)resistance in non-small cell lung cancer
《Signal Transduction and Targeted Therapy》2024年第4期1706-1720,共15页Jian Zhang Kejia Zhao Wenjing Zhou Ran Kang Shiyou Wei Yueli Shu Cheng Yu Yin Ku Yonghong Mao Hao Luo Juqin Yang Jiandong Mei Qiang Pu Senyi Deng Zhengyu Zha Gang Yuan Shensi Shen Yaohui Chen Lunxu Liu 
supported by the National Natural Science Foundation of China (Grants 31771549 to Y.C.,82103251 to J.Z.,82203153 to K.Z.,and 82203574 to S.W.);the 1.3.5 Project for Disciplines of Excellence (Grants ZYGD18021,ZYJC18009,ZYJC21002,and ZYJC21015);the China Postdoctoral Science Foundation (Grants 2020TQ0210 and 2021M692268 to J.Z.);Natural Science Foundation of Sichuan Province (Grant 2022NSFSC1438 to J.Z.).
Despite epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(TKl)have shown remarkable efficacy in patients with EGFR-mutant non-small cell lung cancer(NSCLC),acquired resistance inevitably develops,limiti...
关键词：TET2 TKI RESISTANCE 
Recent Advances in Deciphering the Mechanisms and Biological Functions of DNA Demethylation
《Chinese Journal of Chemistry》2024年第6期645-651,共7页Yang Feng Sheng-Jun Chen Bi-Feng Yuan 
supported by the National Natural Science Foundation of China(22074110);Guangdong Basic and Applied Basic Research Foundation(2022A1515110550);Central Public-interest Scientific Institution Basal Research Fund,South China Sea Fisheries Research institute,CAFS(No.2021TS02);Guangzhou Basic and Applied Basic Research Foundation(2023A04J1337);Central Public-interest Scientific Institution Basal Research Fund,CAFS(No.2023TD78).
5-Methylcytosine (5mC) is a dynamic and reversible epigenetic modification in genomic DNA of higher eukaryotes.It has been well-established that the demethylation of 5mC occurs through the ten-eleven translocation (TE...
关键词：EPIGENETICS DNA DNA methylation 5-Methylcytosine DEMETHYLATION MECHANISMS Biological functions C—C bond cleavage Mass spectrometry 
Regulation of RNA methylation and immune infiltration patterns by m5C regulators in head and neck squamous cell carcinoma
《BIOCELL》2023年第12期2641-2660,共20页SHIDA HOU TIANJUN LAN YAOCHENG YANG PEISHENG LIANG XIN LIU JUNJIE WANG ZHIFENG CHEN RONGSHENG ZENG ZIJING HUANG 
supported by grants from the Guangdong Science and Technology Development Fund(Grant No.2019A1515110662).
5-Methylcytosine(m5C)methylation contributes to the development and progression of various malignant tumors.This study aimed to explore the potential role of m5C methylation regulators(m5CMRs)in head and neck squamous...
关键词：Head and neck squamous cell carcinoma RNA methylation 5-methylcytosine IMMUNOTHERAPY 
Sequencing methods and functional decoding of mRNA modifications被引量：1
《Fundamental Research》2023年第5期738-748,共11页Kai Li Jinying Peng Chengqi Yi 
the Ministry of Science and Technology of China(2019YFA0110902,2019YFA0802201)。
More than 160 types of post-transcriptional RNA modifications have been reported;there is substantial variation in modification type,abundance,site,and function across species,tissues,and RNA type.The recent developme...
关键词：RNA modification N6 2′-O-dimethyladenosine(m6Am) N1-methyladenosine(m1A) 5-Methylcytosine(m5C) N6-methyladenosine(m6A) Pseudouridine(Ψ) Inosine(I) 
Identifying RNA Modifications by Direct RNA Sequencing Reveals Complexity of Epitranscriptomic Dynamics in Rice被引量：3
《Genomics, Proteomics & Bioinformatics》2023年第4期788-804,共17页Feng Yu Huanhuan Qi Li Gao Sen Luo Rebecca Njeri Damaris Yinggen Ke Wenhua Wu Pingfang Yang 
supported by the National Natural Science Foundation of China(Grant No.31671775).
Transcriptome analysis based on high-throughput sequencing of a cDNA library has been widely applied to functional genomic studies.However,the cDNA dependence of most RNA sequencing techniques constrains their ability...
关键词：Direct RNA sequencing Polyadenylated transcriptome N6-methyladenosine N5-methylcytosine RICE 
NSUN2-mediated mRNA m^(5)C Modification Regulates the Progression of Hepatocellular Carcinoma被引量：3
《Genomics, Proteomics & Bioinformatics》2023年第4期823-833,共11页Dan Song Ke An Wenlong Zhai Luyao Feng Yingjie Xu Ran Sun Yueqin Wang Yun-Gui Yang Quancheng Kan Xin Tian 
supported by grants from the National Natural Science Foundation of China(Grant Nos.32170594 and 31870809);the Province and Ministry Coconstruction Major Program of Medical Science and Technique Foundation of Henan Province(Grant No.SBGJ202001007);the Special Fund for Young and Middle School Leaders of Henan Health Commission(Grant No.HNSWJW-2020017),China.
RNA modifications affect many biological processes and physiological diseases.The 5-methylcytosine(m^(5)C)modification regulates the progression of multiple tumors.However,its characteristics and functions in hepatoce...
关键词：5-methylcytosine Hepatocellular carcinoma NSUN2 Ras pathway SORAFENIB 
The diverse role of RNA methylation in esophageal cancer
《Acta Biochimica et Biophysica Sinica》2023年第6期988-1000,共13页Wangyang Meng Yichao Han Bin Li Hecheng Li 
supported by the grants from the National Natural Science Foundation of China(Nos.82072557 and 81871882);the National Key Research and Development Program of China(No.2021YFC2500900);the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant(No.20172005,the 2nd round of disbursement);the Program of Shanghai Academic Research Leader from Science and Technology Commission of Shanghai Municipality(No.20xD1402300).
Esophageal cancer is one of the major life-threatening diseases in the world.RNA methylation is the most common post-transcriptional modification and a wide-ranging regulatory system controlling gene expression.Numero...
关键词：esophageal cancer RNA methylation post-transcriptional modification N6-methyladenosine 5-methylcytosine 7-methylguanosine tumor microenvironment 
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