PRION

作品数：175被引量：154H指数：5
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NG2 Glia:The Guardians Against Prion‑induced Neurotoxicity Through Prostaglandin E2 Blockade
《Neuroscience Bulletin》2025年第3期539-542,共4页Shu Feng Emily Parker Timon Cheng‑Yi Liu Luodan Yang 
supported by the National Natural Science Foundation of China(32300959);a Guangzhou Scientific Research Grant(SL2024A04J00578);the SCNU Young Faculty Development Program(22KJ04).
Neuron glia antigen-2(NG2)glia,also known as oligodendrocyte precursor cells(OPCs),are essential for maintaining the normal function and structure of the central nervous system(CNS)due to their supportive role[1].Unde...
关键词：maintaining normal function structure myelin sheath axons oligodendrocyte precursor cells opcs receiving synaptic input neurons NEUROTOXICITY PRION central nervous system cns due ng glia 
Activation of IP10/CXCR3 Signaling is Highly Coincidental with PrP^(Sc)Deposition in the Brains of Scrapie-Infected Mice
《Biomedical and Environmental Sciences》2024年第11期1235-1251,共17页Chen Jia Chen Cao Hu Chao Yang Wei Wang Lin Chen Dongdong Wu Yuezhang Shi Qi Dong Xiaoping 
supported by SKLID Development Grants(2021SKLID504,2019SKLID401,2019SKLID603,and 2016SKLID603);the National Natural Science Foundation of China(81772197,81401670,and 81630062)。
Objective To analyze the relationship between Chemokine IP10 and its receptor CXCR3 during prion infection.Methods We investigated the increases in IP10 signals,primarily localized in neurons within the brains of scra...
关键词：PRION Chemokine IP10 CXCR3 ACTIVATION 
Decoding the Cellular Trafficking of Prion-like Proteins in Neurodegenerative Diseases
《Neuroscience Bulletin》2024年第2期241-254,共14页Chenjun Hu Yiqun Yan Yanhong Jin Jun Yang Yongmei Xi Zhen Zhong 
supported by the National Natural Science Foundation of China(82071424);the Zhejiang University Education Foundation Global Partnership Fund(188170+194452115/011).
The accumulation and spread of prion-like proteins is a key feature of neurodegenerative diseases(NDs)such as Alzheimer’s disease,Parkinson's disease,or Amyotrophic Lateral Sclerosis.In a process known as‘seeding’,...
关键词：Neurodegenerative diseases Prion-like propagation SEEDING ENDOCYTOSIS Endolyosomal leaking Degradation 
Protein amyloid aggregate:Structure and function被引量：2
《Aggregate》2023年第4期55-70,共16页Qianhui Xu Yeyang Ma Yunpeng Sun Dan Li Xin Zhang Cong Liu 
National Natural Science Foundation(NSF)of China,Grant/Award Numbers:82188101,32171236,31872716,32170683;the Science and Technology Commission of Shanghai Municipality(STCSM),Grant/Award Numbers:20XD1425000,2019SHZDZX02;the Shanghai Pilot Program for Basic Research–Chinese Academy of Science,Shanghai Branch,Grant/Award Number:CYJ-SHFY-2022-005。
Protein amyloid aggregation has been widely observed to occur and plays impor-tant roles in both physiological processes and pathological diseases.Remarkably,amyloid aggregates assembled by native proteins gain a vari...
关键词：amyloidfibril neurodegenerative diseases prion-like propagation protein phase separation protein aggregate 
Extensive Disturbances of Intracellular Components and Dysfunctions of Biological Pathways in the Brain Tissues During Prion Infection—China’s Studies
《China CDC weekly》2022年第33期741-747,共7页Qi Shi Cao Chen Kang Xiao Wei Zhou Chen Gao Liping Gao Jun Han Jichun Wang Xiaoping Dong 
Supported by National Key R&D Program of China(2020YFE0205700);SKLID Development Grant(2021SKLID503,2021SKLID504,2019SKLID401);National Natural Science Foundation of China(81772197,81630062,81401670).
The study describes some of the major findings of changes in intracellular components and biological pathways in the brain during prion infection and hypothesizes some important physiological and pathological approach...
关键词：alterations HOMEOSTASIS summarized 
Global Profiles of Acetylated Proteins in Brains of Scrapie Agents 139A- and ME7-Infected Mice Collected at Mid-Early, Mid-Late, and Terminal Stages
《Biomedical and Environmental Sciences》2022年第8期722-734,共13页SHI Qi CHEN Dong Dong ADALATI Maimaitiming XIAO Kang GAO Li Ping YANG Xue Hua WU Yue Zhang CHEN Cao DONG Xiao Ping 
supported by National Key R&D Program of China [2020YFE0205700];Chinese National Natural Science Foundation Grants [81630062];grants from the State Key Laboratory for Infectious Disease Prevention and Control(China CDC)[Grant Nos.2019SKLID501,2019SKLID603,and 2019SKLID307]
Objective To describe the global profiles of acetylated proteins in the brains of scrapie agents 139Aand ME7-infected mice collected at mid-early,mid-late,and terminal stages.Methods The acetylated proteins from the c...
关键词：PRION Scrapie-infected mouse Acetylation Proteomics Kyoto Encyclopedia of Genes and Genomes pathway 
Astrocyte in prion disease: a double-edged sword被引量：2
《Neural Regeneration Research》2022年第8期1659-1665,共7页Waqas Tahir Simrika Thapa Hermann M.Schatzl 
supported by grants from Alberta Innovates/Alberta Prion Research Institute(APRI grants 201600010 and 201900008)(to HMS);ST had received a University of Calgary Eyes High,Killam and Alberta Innovates Health Solution(AIHS)doctoral fellowship.
Prion diseases are infectious protein misfolding disorders of the central nervous system that result from misfolding of the cellular prion protein(PrPC)into the pathologic isoform PrPSc.Pathologic hallmarks of prion d...
关键词：Alzheimer’s disease ASTROCYTES central nervous system Creutzfeldt-Jakob disease glial cells NEURODEGENERATION PRION prion disease prion protein SCRAPIE 
Rarely fast progressive memory loss diagnosed as Creutzfeldt-Jakob disease:A case report
《World Journal of Clinical Cases》2021年第34期10638-10644,共7页Yong-Wei Xu Jie-Qun Wang Wei Zhang Shu-Chang Xu Yun-Xia Li 
Shanghai Shenkang Hospital Development Center,No.SHDC12016109.
BACKGROUND Creutzfeldt-Jakob disease(CJD)is a rare degenerative disease of the central nervous system that can be contagious or hereditary and is a rare cause of rapidly progressive dementia.It almost always results i...
关键词：Creutzfeldt-Jakob disease Prion disorders Progressive memory loss DEMENTIA Case report 
Differential seeding and propagating efficiency ofα-synuclein strains generated in different conditions
《Translational Neurodegeneration》2021年第2期257-271,共15页Di Liu Jian-Jun Guo Ji-Hui Su Alexander Svanbergsson Lin Yuan Caroline Haikal Wen Li Gunnar Gouras Jia-Yi Li 
Financial supports of JYL lab by the National Key Research and Development Program of China(2018YFA0108500);the National Natural Science Foundation(81430025,81701265,31800898,U1801681);the Key Field Research Development Program of Gungdong Province(2018B030337001);Financial supports of JYL lab by the Swedish Research Council(521-2014-3257,2019-01551);EU-JPND(aSynProtec)and EU-JPND(REfrAME);EU H2020-MSCA-ITN-2016(Syndegen);the Strong Research Environment MultiPark(Multidisciplinary research on Parkinson’s disease);Parkinsonfonden and Olle Engkvist Byggmästare Foundation.DL was supported by China Scholarship Council.Open Access funding provided by Lund University。
Background:Accumulation of alpha-synuclein(α-syn)is a main pathological hallmark of Parkinson’s and related diseases,which are collectively known as synucleinopathies.Growing evidence has supported that the same pro...
关键词：Α-SYNUCLEIN STRAINS Prion-like propagation Parkinson’s disease 
Tumor Necrosis Factor a Reduces SNAP29 Dependent Autolysosome Formation to Increase Prion Protein Level and Promote Tumor Cell Migration
《Virologica Sinica》2021年第3期458-475,共18页Huan Li Ren Wang Ze Yu Run Shi Jie Zhang Shanshan Gao Ming Shao Shuzhong Cui Zhenxing Gao Jiang Xu Man-Sun Sy Chaoyang Li 
supported by grants from the National Science Foundation of China (31670170 & 81560442);from MOST (2018YFA0507201);from the Natural Science Foundation of Guangdong Province (2017ZC0236)。
Tumor Necrosis Factor α(TNFα) is best known as a mediator of inflammation and immunity, and also plays important roles in tumor biology. However, the role of TNFα in tumor biology is complex and not completely unde...
关键词：Tumor necrosis factorα(TNFα) Prion protein Synaptosome associated protein 29(SNAP29) Autophagy Nuclear factor kappa B(NF-κB) Forkhead box P3(FOXP3) 
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