ANTIANGIOGENIC

作品数:44被引量:166H指数:7
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相关领域:医药卫生生物学更多>>
相关作者:马仲才胥彬权雯钱晓萍更多>>
相关机构:中国科学院吉林大学白求恩第一医院南京医科大学南京大学医学院附属鼓楼医院更多>>
相关期刊:《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《International Journal of Ophthalmology(English edition)》《Hepatobiliary & Pancreatic Diseases International》更多>>
相关基金:国家自然科学基金国家高技术研究发展计划南京市卫生局重点基金更多>>
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Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy
《Chinese Chemical Letters》2024年第7期377-382,共6页Mengjuan Sun Muye Zhou Yifang Xiao Hailei Tang Jinhua Chen Ruitao Zhang Chunjiayu Li Qi Ya Qian Chen Jiasheng Tu Qiyue Wang Chunmeng Sun 
supported by the National Natural Science Foundation of China(Nos.81972894,22278442,82273882)。
Size is one of the most important characteristics of nanoparticles to influence their biodistribution and antitumoral efficacy.Particles with large sizes have difficulty in deep tumor penetration,while small particles...
关键词:Polyion complex micelle Size-switchable Revisable size-change pH response Antiangiogenic cancer 
OPA3 overexpression modulates lipid droplet production and sensitizes colorectal cancer cells to bevacizumab treatment
《BIOCELL》2024年第6期971-980,共10页HONGBIAO WU DONGFANG LIU 
Background:Colorectal cancer(CRC)represents a substantial risk to public health.Bevacizumab,thefirst US FDA-approved antiangiogenic drug(AAD)for human CRC treatment,faces resistance in patients.The role of lipid metabo...
关键词:Colorectal cancer OPA3 BEVACIZUMAB Lipid droplet Antiangiogenic drug 
Mechanisms of tyrosine kinase inhibitor resistance in renal cell carcinoma被引量:3
《Cancer Drug Resistance》2023年第4期858-873,共16页Patrick L.Sweeney Yash Suri Arnab Basu Vadim S.Koshkin Arpita Desai 
Renal cell carcinoma(RCC),the most prevalent type of kidney cancer,is a significant cause of cancer morbidity and mortality worldwide.Antiangiogenic tyrosine kinase inhibitors(TKls),in combination with immune checkpoi...
关键词:Antiangiogenic tyrosine kinase inhibitors renal cell carcinoma acquired resistance SUNITINIB tumor microenvironment immune checkpoint inhibitors 
Metabolic reprogramming of the ovarian cancer microenvironment in the development of antiangiogenic resistance被引量:1
《Acta Biochimica et Biophysica Sinica》2023年第6期938-947,共10页Huiran Yue Xin Lu 
supported by the grants from the National Natural Science Foundation of China(No.82072877).
Antiangiogenic therapies,such as treatment with bevacizumab,display modest survival benefits in ovarian cancer(OC)patients.After a transient response,the upregulation of compensatory proangiogenic pathways and the ado...
关键词:ovarian cancer tumor microenvironment antiangiogenic therapy METABOLISM 
The role of antiangiogenic monoclonal antibodies combined to EGFR-TKIs in the treatment of advanced non-small cell lung cancer with activating EGFR mutations: acquired resistance mechanisms and strategies to overcome them被引量:4
《Cancer Drug Resistance》2022年第4期1016-1024,共9页Danilo Rocco Luigi Della Gravara Giovanni Palazzolo Cesare Gridelli 
As of today, only two antiangiogenic monoclonal antibodies plus epidermal growth factor receptor-tyrosine kinaseinhibitor (EGFR-TKI) combinations are FDA and EMA-approved and are recommended by American Society ofClin...
关键词:NSCLC EGFR T790M MET BEVACIZUMAB ramucirumab TKI resistance mechanisms 
Combining PD1 inhibitor,PARP inhibitor and antiangiogenic medication for lung squamous cell carcinoma with liver metastasis:a case report
《Precision Medicine Research》2022年第4期1-5,共5页Ruo-Qi Wang Shan-Qi Guo Jun Chen Wen-Yan Fang 
A 68-year-old man with left chest pain accompanied by chest tightness was reported.The computed tomography revealed a massive liver mass.Genetic and pathological tests confirmed advanced squamous cell lung carcinoma w...
关键词:IMMUNOTHERAPY Programmed cell death protein 1 squamous cell carcinoma Poly ADP-ribose polymerase inhibitors 
Update on the treatment of metastatic renal cell carcinoma被引量:1
《World Journal of Clinical Oncology》2022年第1期1-8,共8页Rafael Antonio Medina Lopez Ines Rivero Belenchon Javier Mazuecos-Quiros Carmen Belen Congregado-Ruiz Felipe Counago 
Metastatic renal cell cancer(mRCC)management has undergone a paradigm shift in recent decades.The first revolution came with the emergence of vascular endothelial growth factor inhibitors;there was a second wave with ...
关键词:Metastatic renal cell carcinoma Systemic treatment Immune checkpoint inhibitors ANTIANGIOGENIC UPDATE Biomarkers 
Ultrasound activatable antiangiogenic sonosensitizer for VEGFR associated glioblastoma tumor models
《Aggregate》2021年第4期137-143,共7页Subin Son Chuangli Zhang Miae Won Paramesh Jangili Minhyeok Choi Jiasheng Wu Jong Seung Kim 
National Research Foundation ofKorea,Grant/Award Numbers:2018R1A3B1052702,2019M3E5D1A01068998;Basic Science Research Program,Grant/Award Number:2020R1A6A3A01100551;Ministry ofEducation,andNationalNatural Science Foundation of China,Grant/Award Number:21673265。
Angiogenic signaling pathway is a major contributing factor in cancer recurrence and progression,which can cause significantly reduced treatment outcomes,especially in the oxygen-dependent photo-and sonodynamic therap...
关键词:ANTIANGIOGENESIS GLIOBLASTOMA sonodynamic therapy VEGFR blockage 
The antiangiogenic phloroglucinol hyperforin inhibits the secretion of proMMP-2, proMMP-9 and VEGF-A during apoptosis of primary acute myeloid leukemia cells
《Journal of Cancer Metastasis and Treatment》2021年第1期588-603,共16页Faten Merhi Ruoping Tang Ollivier Legrand Florence Nguyen-Khac Santos A.Susin Brigitte Bauvois 
supported by the French National Institute of Health and Medical Research(INSERM).This research received no external funding.
Aim:Angiogenesis is observed in acute myeloid leukemia(AML).AML cells abnormally proliferate and are resistant to death.Positive regulators of angiogenesis,VEGF-A and matrix metalloproteinases(MMPs)2 and 9 are markers...
关键词:Acute myeloid leukemia APOPTOSIS HYPERFORIN matrix metalloproteinase VEGF SECRETION 
Multiline treatment of advanced squamous cell carcinoma of the lung: A case report and review of the literature被引量:1
《World Journal of Clinical Cases》2019年第14期1899-1907,共9页Xin Yang Ping Peng Li Zhang 
BACKGROUND Squamous cell carcinoma (SCC) is one the most common subtypes of non-small cell lung cancer, yet the treatment options for it remain limited. Here, we report a case of advanced SCC and review the related li...
关键词:SQUAMOUS cell carcinoma Chemotherapy NAB-PACLITAXEL ANAPLASTIC LYMPHOMA kinase-targeted THERAPY ANTIANGIOGENIC THERAPY 
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