supported by the National Natural Science Foundation of China(Nos.81972894,22278442,82273882)。
Size is one of the most important characteristics of nanoparticles to influence their biodistribution and antitumoral efficacy.Particles with large sizes have difficulty in deep tumor penetration,while small particles...
Background:Colorectal cancer(CRC)represents a substantial risk to public health.Bevacizumab,thefirst US FDA-approved antiangiogenic drug(AAD)for human CRC treatment,faces resistance in patients.The role of lipid metabo...
Renal cell carcinoma(RCC),the most prevalent type of kidney cancer,is a significant cause of cancer morbidity and mortality worldwide.Antiangiogenic tyrosine kinase inhibitors(TKls),in combination with immune checkpoi...
supported by the grants from the National Natural Science Foundation of China(No.82072877).
Antiangiogenic therapies,such as treatment with bevacizumab,display modest survival benefits in ovarian cancer(OC)patients.After a transient response,the upregulation of compensatory proangiogenic pathways and the ado...
As of today, only two antiangiogenic monoclonal antibodies plus epidermal growth factor receptor-tyrosine kinaseinhibitor (EGFR-TKI) combinations are FDA and EMA-approved and are recommended by American Society ofClin...
A 68-year-old man with left chest pain accompanied by chest tightness was reported.The computed tomography revealed a massive liver mass.Genetic and pathological tests confirmed advanced squamous cell lung carcinoma w...
Metastatic renal cell cancer(mRCC)management has undergone a paradigm shift in recent decades.The first revolution came with the emergence of vascular endothelial growth factor inhibitors;there was a second wave with ...
National Research Foundation ofKorea,Grant/Award Numbers:2018R1A3B1052702,2019M3E5D1A01068998;Basic Science Research Program,Grant/Award Number:2020R1A6A3A01100551;Ministry ofEducation,andNationalNatural Science Foundation of China,Grant/Award Number:21673265。
Angiogenic signaling pathway is a major contributing factor in cancer recurrence and progression,which can cause significantly reduced treatment outcomes,especially in the oxygen-dependent photo-and sonodynamic therap...
supported by the French National Institute of Health and Medical Research(INSERM).This research received no external funding.
Aim:Angiogenesis is observed in acute myeloid leukemia(AML).AML cells abnormally proliferate and are resistant to death.Positive regulators of angiogenesis,VEGF-A and matrix metalloproteinases(MMPs)2 and 9 are markers...
BACKGROUND Squamous cell carcinoma (SCC) is one the most common subtypes of non-small cell lung cancer, yet the treatment options for it remain limited. Here, we report a case of advanced SCC and review the related li...