PHYSIOLOGY

作品数：463被引量：1384H指数：17
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Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders
《Neural Regeneration Research》2025年第8期2302-2303,共2页Asma Boulksibat Alessandra Tempio Barbara Bardoni 
The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular processes.In the brain,these p...
关键词：formation processes finally 
Transcription factor ELF4 in physiology and diseases:Molecular roles and clinical implications
《Genes & Diseases》2025年第3期329-346,共18页Dian Hu Zerui Zhang Yijun Wang Siwen Li Jiaqian Zhang Zhangfan Wu Mengyu Sun Junqing Jiang Danfei Liu Xiaoyu Ji Shuai Wang Yufei Wang Xiangyuan Luo Wenjie Huang Limin Xia 
funded by the National Natural Science Foundation of China(No.U23A20451,82273310,82372917,82173313);the Natural Science Foundation of Hubei Province,China(No.2022CFA016);the Basic Research Support Program of Huazhong University of Science and Technology(China)(No.2023BR038).
Transcription factor E74 like ETS transcription factor 4(ELF4),a member of the ETS family,is highly expressed in normal human hematopoietic tissue,ovary,placenta,colon,and certain pathological cell lines.During normal...
关键词：BIOMARKER Cancer ELF4/MEF Immune system METASTASIS 
Advances in the pathophysiology and treatment of focal segmental glomerulosclerosis:The importance of a timely and tailored approach
《World Journal of Nephrology》2025年第2期1-8,共8页Guido Gembillo Concetto Sessa Domenico Santoro 
Focal segmental glomerulosclerosis(FSGS)is a histological pattern of glomerular damage that significantly contributes to chronic kidney disease and end-stage renal disease.Its incidence is rising globally,necessitatin...
关键词：Focal segmental glomerulosclerosis Chronic kidney disease GLOMERULONEPHRITIS Renal failure Immunosuppressive therapy Calcineurin inhibitors Mycophenolate mofetil RITUXIMAB Sparsentan PLASMAPHERESIS 
The impacts of PVC microplastics on physiology and transcriptomic responses of pearl oyster Pinctada fucata martensii
《Journal of Oceanology and Limnology》2025年第2期589-613,共25页Robert MKUYE Luomin HUANG Chuangye YANG Xiuyan YANG Fortunatus MASANJA Salifu IBRAHIM Fenglan LU Shaojie ZHU Hailing WU Yuewen DENG 
Supported by the Science and Technology Program of Guangdong Province(No.2022A1515010030);the National Natural Science Foundation of China(No.32102817);the Department of Education of Guangdong Province(Nos.2020ZDZX1045,2021KCXTD026);the earmarked fund for CARS-49,Students Innovation and Entrepreneurship Training Program(No.CXXL2022015);the Technology Program of Guangdong Zhanjiang(No.2022A01010);the Hengli Biosciences Excellence Project of Guangdong Ocean University(No.B23335-4)。
Microplastics(MPs),particularly polyvinyl chloride microplastics(PVC MPs)have become a notable environmental pollutant that affect various marine organisms such as Pinctada fucata martensii.As filter feeders,these biv...
关键词：microplastic(MP) Pinctada fucata martensii oxidative stress TRANSCRIPTOME 
Inhibition mechanisms of perchlorate on the photosynthesis of cyanobacterium Synechocystis sp.PCC6803:Insights from physiology and transcriptome analysis
《Journal of Environmental Sciences》2025年第4期515-531,共17页Xianyuan Zhang Yixiao Zhang Zixu Chen Lanzhou Chen Xiaoyan Li Gaohong Wang 
supported by the Project of Chinese Manned Spaceflight(No.YYWT-0801-EXP-09);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA17010502);Jiangsu Province Ecological Environment Scientific Research Project(No.2022008).
Perchlorate(ClO_(4)^(−))is a type of novel persistent inorganic pollutant that has gained increasing attention because of its high solubility,poor degradability,and widespread distribution.However,the impacts of perch...
关键词：PERCHLORATE SYNECHOCYSTIS PHOTOSYNTHESIS Oxidative stress TRANSCRIPTOME 
Awake prone positioning and ventilation distribution as assessed by electric impedance tomography in patients with non-COVID-19 acute hypoxemic respiratory failure:A prospective physiology study
《Journal of Intensive Medicine》2025年第1期43-50,共8页Jingjing Wang Changxing Chen Zhanqi Zhao Puyu Deng Chenchen Zhang Yu Zhang Hui Lv Daonan Chen Hui Xie Ruilan Wang 
supported by National Clinical Key Specialty(grant number:Z155080000004));Clinical management optimization project of SHDC(grant number:SHDC22022206).
Background:Awake prone positioning(APP)can reportedly reduce the need for intubation and help improve prognosis of patients with acute hypoxemic respiratory failure(AHRF)infected with COVID-19.However,its physiologica...
关键词：Acute hypoxemic respiratory failure Prone positions Electrical impedance tomography 
Innovative Approaches to Reforming Physiology Experiment Teaching under the New Medical Sciences Framework
《Journal of Educational Theory and Management》2025年第1期24-28,共5页Hongmei Dai Yanjun Zhao Xianguang Bai 
supported by the Key Teaching Reform and Practice Project of Pingdingshan University in 2023,titled“Research and Practice on Innovation and Entrepreneurship Pathways for Medical Students under the New Medical Discipline Framework”(Project No.2023-JYZD15);Additionally,this study received support from the Henan Province Higher Education Teaching Reform Research and Practice Project,titled“Research on the Integration Path of Medical Education and Innovation&Entrepreneurship Education under the‘Project-based+Mentorship System’Model”(Project No.2024SJGLX0495).
The construction of the New Medical Sciences aims to cultivate interdisciplinary medical talents,placing higher demands on physiology experiment teaching.In light of the challenges of traditional teaching,such as outd...
关键词：New Medical Sciences Physiology Experiment Teaching Reform 
From Physiology to Pathology of Astrocytes:Highlighting Their Potential as Therapeutic Targets for CNS Injury
《Neuroscience Bulletin》2025年第1期131-154,共24页Yimin Yuan Hong Liu Ziwei Dai Cheng He Shangyao Qin Zhida Su 
supported by the National Natural Science Foundation of China(82171386,81971161,and 82201536);the Shanghai Science and Technology Development Foundation(22YF1458600);the Scientifc Foundation from Naval Medical University(2021QN08);the STI2030-Major Projects from Ministry of Science and Technology of China(2022ZD0204700).
In the mammalian central nervous system(CNS),astrocytes are the ubiquitous glial cells that have complex morphological and molecular characteristics.These fascinating cells play essential neurosupportive and homeostat...
关键词：ASTROCYTES Reactive astrocyte ASTROGLIOSIS CNS injury REPAIR 
An integrated physiology and proteomics analysis reveals the response of wheat grain to low temperature stress during booting
《Journal of Integrative Agriculture》2025年第1期114-131,共18页Anmin Zhang Zihong Li Qirui Zhou Jiawen Zhao Yan Zhao Mengting Zhao Shangyu Ma Yonghui Fan Zhenglai Huang Wenjing Zhang 
supported by the National Natural Science Foundation of China(32372223);the National Key Research and Development Program of China(2022YFD2301404);the College Students'Innovationand Entrepreneurship Training Program of Anhui Province,China(S202210364136);the Natural Science Research Project of Anhui Educational Committee,China(2023AH040133).
Low temperature(LT)in spring has become one of the principal abiotic stresses that restrict the growth and development of wheat.Diverse analyses were performed to investigate the mechanism underlying the response of w...
关键词：low temperature at booting WHEAT GRAIN starch synthesis PROTEOMICS 
Physiology and health assessment,risk balance,and model for endstage liver disease scores:Postoperative outcome of liver transplantation
《World Journal of Transplantation》2025年第1期86-94,共9页Raquel Hohenreuther Andresa ThoméSilveira Edison Moraes Rodrigues Filho Anderson Garcez Bruna Goularth Lacerda Sabrina Alves Fernandes Claudio Augusto Marroni 
BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of life.The number of organs available for transplantation is lower than the demand.To...
关键词：Liver transplantation Acute physiology and chronic health evaluation IV Balance of risk Model for end-stage liver disease MORTALITY Intensive care unit 
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