CELL-CYCLE

作品数:27被引量:86H指数:5
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相关领域:医药卫生生物学更多>>
相关作者:崔景荣李润涛袁霞张明敏黄光英更多>>
相关机构:北京大学华中科技大学咸宁学院加州大学更多>>
相关期刊:《Signal Transduction and Targeted Therapy》《American Journal of Molecular Biology》《光谱学与光谱分析》《Science Bulletin》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金上海市自然科学基金更多>>
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Guarding against digestive-system cancers:Unveiling the role of Chk2 as a potential therapeutic target
《Genes & Diseases》2025年第1期195-208,共14页Yucheng An Duolun Gao Yanjie He Nan Ge Jintao Guo Siyu Sun Caixia Wang Fan Yang 
supported by the National Natural Science Foundation of China(No.82100700 to F.Y.);the China Postdoctoral Science Foundation(No.2020M670101ZX to F.Y.);the Fundamental Scientific Research Project from the Educational Department of Liaoning Province,China(No.LJKMZ20221191 to F.Y.);the 345 Talent Project of Shengjing Hospital of China Medical University(No.52-30B to F.Y.).
Digestive-system cancers represent major threats to human health;however,the mechanisms underlying tumorigenesis and radiochemotherapy resistance have remained elusive.Therefore,an urgent need exists for identifying k...
关键词:Checkpointkinase 2 Cell-cyclearrest Digestive-system cancer Radiochemotherapy resistance Tumorigenesis 
Effects of Serum Concentration, Synchronization Time and Confluence on the Cell-Cycle Synchronization Efficiency of Goat Fibroblasts
《Open Journal of Animal Sciences》2024年第3期194-203,共10页Van Khanh Nguyen Huong Thu Thi Vu Au Thi Hoang Yen Kim Thi Pham Giang Thi Thanh Nhan Hung Phu Lai Lan Doan Pham 
This study aims to evaluate the effect of serum concentration, synchronization time, and confluence degree on the synchronisation efficiency of goat fibroblast cycle. The results indicated that there was no difference...
关键词:Goat Fibroblast Cycle Synchronisation Serum Concentration Synchronization Time CONFLUENCE 
Cell-cycle dependent nuclear gene delivery enhances the effects of E-cadherin against tumor invasion and metastasis被引量:6
《Signal Transduction and Targeted Therapy》2023年第6期3039-3054,共16页Liting Xie Jieqiong Wang Liming Song Tianan Jiang Fei Yan 
supported by National Key R&D Program of China(Grant Number.2020YFA0908800);National Natural Science Foundation of China(Grant Number.81871376,32171365,82027803,81971623 and 82202151);Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Number.XDB0480000);China Postdoctoral Science Foundation(Grant Number.2021M700121);Shenzhen Science and Technology Innovation Committee(Grant Number.JCYJ20190812171820731);Shenzhen Institute of Synthetic Biology Scientific Research Program(Grant Number.JCHZ20210002).
Gene delivery is the process by which foreign DNA is transferred to host cells,released from intracellular vesicles,and transported to the nuclei for transcription.This process is frequently inefficient and difficult ...
关键词:INVASION METASTASIS inhibited 
Anti-melanoma action of small molecular peptides derived from Brucea javanica(L.)Merr.globulin in vitro被引量:1
《Journal of Traditional Chinese Medical Sciences》2022年第1期85-91,共7页Yi Zhao Huiyun Wang Yanyan Yin Haoyu Shi Dong Wang Fengjue Shu Rongchun Wang Lingzhi Wang 
This experiment was supported by the National Natural Science Foundation of China(No.81872972).
Objective:The morbidity of malignant melanoma keeps increasing annually.It has high risks of metastasis,drug resistance,and poor prognosis in clinics.Moreover,the available medicines used commonly,such as dacarbazine,...
关键词:Brucea javanica(L.)Merr. Melanoma GLOBULIN In vitro wound-scratch assay Peptide Cell-cycle assay Apoptosis assay Hydrolyze 
Cell-cycle length of medial ganglionic eminence progenitors contributes to interneuron fate
《Protein & Cell》2022年第2期141-147,共7页Ni Zong Min Wang Yinghui Fu Dan Shen Yong-Chun Yu 
This work was supported by grants from the Shanghai Natural Science Foundation(20ZR1403800)to Y.F.The project was also supported by the Natural Science Foundation of China(31930044,31725012);the Foundation of Shanghai Municipal Education Commission(2019-01-07-00-07-E00062);the Collaborative Innovation Program of Shanghai Municipal Health Commission(2020CXJQ01);the Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01).
Dear Editor,GABAergic interneurons contribute to cortical function by regulating the balance of activity.Malfunction of inhibitory interneurons has been associated with neuropsychiatric disorders(Hashimoto et al.2003;...
关键词:MEDIAL CYCLE striking 
The multifaceted PDCD10/CCM3 gene被引量:2
《Genes & Diseases》2021年第6期798-813,共16页Mariaelena Valentino Elisabetta Dejana Matteo Malinverno 
The lab of ED is supported by:The Swedish Research Council(contract No.2013-9279),the Knut and Alice Wallenberg Foundation(contract No.2015-0030),the European Research Council(project EC-ERC-VEPC,contract 74292),Associazione Italiana per la Ricerca sul Cancro(AIRC IG 23223),AIRC 5x1000 call"Metastatic disease:the key unmet need in oncology"to the MYNERVA Project(MYeloid NEoplasms Research Venture AIRC 21267),Telethon(New insight on the pathogenesis of hereditary Cerebral Cavernous Malformation,contract GGP19202);AIFA(a multicellular randomized clinical trial on propranolol in familial Cerebral Cavernous Malformation,contract AIFA-2016-02364593).Be Brave for Life Foundation Micro Grant 2019.
The programmed cell death 10(PDCD10)gene was originally identified as an apoptosis-related gene,although it is now usually known as CCM3,as the third causative gene of cerebral cavernous malformation(CCM).CCM is a neu...
关键词:CANCER Cell signaling CELL-CYCLE Neurovascular unit PDCD10/CCM3 
Lower Concentrations of Glucose or Insulin Decrease the Risk of Various Types of Cancer in the Long-Lived Ames Dwarf Mouse by Increasing the Expression of p27Kip1, a Cell-Cycle Repressor Protein
《American Journal of Molecular Biology》2020年第3期148-164,共17页Isao Eto 
Introduction. The molecular biological mechanism of the increased incidence of the various types of cancer in obesity or...
关键词:Cancer Glucose INSULIN Caloric Restriction Long-Lived Ames Dwarf Mouse P27KIP1 Cell-Cycle Repressor Protein 
THZ1 suppresses human non-small-cell lung cancer cells in vitro through interference with cancer metabolism被引量:5
《Acta Pharmacologica Sinica》2019年第6期814-822,共9页Zhu-Jun Cheng Du-Ling Miao Qiu-Yun Su Xiao-Li Tang Xiao-Lei Wang Li Bin Deng Hui Donq Shi Hong-Bo Xin 
National Natural Science Foundation of China (91639106 to H-bX, 81660041 to L-bD);National Basic Research Program of China (2013CB531103 to H-bX and L-bD);Jiangxi Province Science Foundation for Youths (20122BA B215020 to H-wC).
Cancer cells always require more nutrients, energy, and biosynthetic activity to sustain their rapid proliferation than normal cells. Previous studies have shown the impact of THZ1, a covalerrt inhibitor of ryHirwjepe...
关键词:THZ1 CDK7 inhibitor non small CELL lung cancer anti PROLIFERATIVE effect CELL-CYCLE ARREST CELL apoptosis GLYCOLYSIS pathway qlutamine metabolism CB-839 
The combination of four cell-cycle regulators: a new direction for inducing adult cardiomyocyte proliferation
《Acta Biochimica et Biophysica Sinica》2019年第4期452-454,共3页Yiyuan Yang Kai Zhang Linxi Chen Lanfang Li 
National Natural Science Foundation of China (No. 81670265);Hunan Provincial Natural Science Foundation (No. 2017JJ2227).
Cardiomyocytes, also known as myocardial fibers, are the muscle cells which form the heart tissue. Previous studies have indicated that fetal mammalian cardiomyocytes maintain the regeneration capacity, which promotes...
关键词:INDUCING ADULT CARDIOMYOCYTE proliferation myocardial infarction(MI) regeneration capacity 
Role of Self-Loop in Cell-Cycle Network of Budding Yeast
《Open Journal of Biophysics》2019年第1期10-20,共11页Shu-ichi Kinoshita Hiroaki Yamada 
Study of network dynamics is very active area in biological and social sciences. However, the relationship between the network structure and the attractors of the dynamics has not been fully understood yet. In this st...
关键词:Gene Regulatory NETWORK ATTRACTORS BUDDING Yeast Degenerate Self-Loop 
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