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作品数：282被引量：715H指数：11
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Shared mechanisms and pathological phenotypes underlying aminoacyl-tRNA synthetase-related neuropathies
《Neural Regeneration Research》2026年第1期312-313,共2页Elena R.Rhymes James N.Sleigh 
funding from the Medical Research Council (MR/S006990/1, MR/Y010949/1);the Rosetrees Trust (M806);the UCL Neurogenetic Therapies Programme funded by The Sigrid Rausing Trust and the UCL Therapeutic Acceleration Support scheme supported by funding from MRC IAA 2021 UCL MR/X502984/1 (to JNS)。
Charcot-Marie-Tooth disease(CMT) is a heterogeneous group of inherited peripheral neuro pathies;it is characterized by muscle weakness and wasting,as well as sensory dysfunction,that typically begins during adolescenc...
关键词：conduction DEGENERATE typically 
Role of per-and polyfluoroalkyl substances in the cardiorenal system:Unraveling crosstalk from the network of pollutants and phenotypes
《Journal of Environmental Sciences》2025年第4期116-133,共18页Ming Yang Jiaxin Zhao Ziwen An Haoran Li Chaoying Ma Junli Lv Fang Xiao Zhenzhen Tan Longfei Li Xiaoguang Zhang Xuehui Liu Yi Liu Ang Li Huicai Guo 
supported by the China Postdoctoral Science Foundation(Nos.2023M730317 and 2023T160066);the Fundamental Research Funds for the Central Universities(No.3332023042);the Open Project of Hebei Key Laboratory of Environment and Human Health(No.202301);the Programs of the National Natural Science Foundation of China(No.21976050);the Science and Technology Program of Hebei Province(No.21377779D);the Natural Science Foundation of Hebei Province,China(No.B2020206008).
Although per-and polyfluoroalkyl substances(PFAS)have been frequently linked to cardiovascular and renal disease separately,evidence remains scarce regarding their systematic effect.Therefore,we recruited 546 newly di...
关键词：Per-and polyfluoroalkyl substances Cardiorenal system Network analysis Acute coronary syndrome 
Halt aging? — functional HSCs lead the way
《Cell Research》2025年第3期157-158,共2页Rebecca T.Chu Adam B.Schroer Saul A.Villeda 
The aged immune system contributes to systemic aging,serving as a driver of morbidity and mortality in the elderly.In a recent Cell Research paper,Wang et al.identified both resilient and dysfunctional subsets of old ...
关键词：hematopoietic stem cells hscs dysfunctional hscs immune system cell research aging phenotypes functional hscs therapeutic targets systemic aging hematopoietic stem cells 
Unlocking the power of tandem repeat variations to fine-tune rice phenotypes
《Science Bulletin》2025年第3期297-298,共2页Kang Chong 
The diversity of crop phenotypes is shaped by numerous genomic variants.For staple cereals like rice,lots of functional variants,including quantitative trait locus(QTLs),have been identified and used to improve variou...
关键词：CULTIVAR CEREAL PRECISE 
Reducing functionally defective old HSCs alleviates agingrelated phenotypes in old recipient mice
《Cell Research》2025年第1期45-58,共14页Yuting Wang Wenhao Zhang Chao Zhang Hoang QTran Van Takashi Sein Yi Zhang 
Aging is a process accompanied by functional decline in tissues and organs with great social and medical consequences.Developing effective anti-aging strategies is of great significance.In this study,we demonstrated t...
关键词：HSCS ORGANS aging 
Spread of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Clinical Isolates from Patients in Bobo-Dioulasso, Burkina Faso
《Journal of Biosciences and Medicines》2025年第1期394-405,共12页Kobo Gnada Michel Kiréopori Gomgnimbou Armel Moumouni Sanou Louis Robert W. Belem Azouman Da Arnaud Quetin Sanou Do Malick Soufiane Sanou 
Antimicrobial resistance (AMR) is one of the top 10 threats to global health and it is estimated around 10 millions of deaths per year are associated with AMR until 2050. Burkina Faso is also facing the emergence and ...
关键词：ENTEROBACTERIACEAE ESBL RESISTANCE ANTIBIOGRAM PHENOTYPES Burkina Faso 
AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice
《Neural Regeneration Research》2025年第1期253-264,共12页Zhengwei Hu Jing Yang Shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu 
supported by the National Natural Science Foundation of China,Nos.91849115 and U1904207(to YX),81974211 and 82171247(to CS);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences,No.2020-PT310-01(to YX).
The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control system.In this study,we aimed...
关键词：adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy 
Repressor elements provide insights into tissue development and phenotypes in pigs
《Zoological Research》2024年第6期1313-1326,共14页Yue-Dong Zhang Chao Guo Hang Liu Yun Gao Yongjun Tan Longjian Niu Ligang Wang Lixian Wang David MIrwin Chunhui Hou Zhong-Yin Zhou Ya-Ping Zhang 
supported by the Science&Technology Department of Yunnan Province (202102AE090039);National Natural Science Foundation of China (32100502);Yunnan Revitalization Talent Support Program Young Talent Project;CAS “Light of West China”Program;Spring City Plan:High-level Talent Promotion and Training Project of Kunming (2022SCP001);CAS Key Technology Talent Program to Y.G。
Repressor elements significantly influence economically relevant phenotypes in pigs;however,their precise roles and characteristics are inadequately understood.In the present study,we employed H3K27me3 profiling,assay...
关键词：Repressor elements Super repressor elements SILENCER Regulatory model Tissue development KLF4 Pig 
Gut microbiota and mesenteric adipose tissue interactions in shaping phenotypes and treatment strategies for Crohn’s disease
《World Journal of Gastroenterology》2024年第46期4969-4976,共8页Anis Hasnaoui Racem Trigui Mario Giuffrida 
In this letter,we commented on the article by Wu et al.We examined the interactions between mesenteric adipose tissue,creeping fat,and gut microbiota in Crohn’s disease(CD),a condition marked by chronic gastrointesti...
关键词：Crohn’s disease Intestinal microbiota DYSBIOSIS Intestinal barrier Mesenteric adipose tissue Creeping fat Fecal microbiota transplantation 
Helicobacter pylori infection is associated with the risk and phenotypes of cholelithiasis:A multi-center study and meta-analysis被引量：1
《World Journal of Gastroenterology》2024年第47期4991-5006,共16页Shuo-Yi Yao Xin-Meng Li Ting Cai Ying Li Lun-Xi Liang Xiao-Ming Liu Yu-Feng Lei Yong Zhu Fen Wang 
Supported by the National Natural Science Foundation of China,No.82270594;the National Natural Science Foundation for Youths of China,No.82103151;the Outstanding Youth Foundation of Hunan Province,No.2022JJ20092;the Wisdom Accumulation and Talent Cultivation Project of Third Xiangya Hospital of Central South University,No.YX202103.
BACKGROUND Helicobacter pylori(H.pylori)is a prevalent pathogen associated with various diseases.Cholelithiasis is also a common condition.H.pylori infection has been identified in the biliary system,suggesting its po...
关键词：Helicobacter pylori CHOLELITHIASIS BILIRUBIN CHOLESTEROL MULTI-CENTER 
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