HIJACKING

作品数：19被引量：41H指数：4
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相关领域：自动化与计算机技术更多>>
相关作者：丁玉强许琪更多>>
相关机构：中国医学科学院基础医学研究所郑州航空工业管理学院同济大学更多>>
相关期刊：《Social Networking》《Science Bulletin》《科技经济市场》《Molecular Plant》更多>>
相关基金：国家自然科学基金中国博士后科学基金更多>>
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SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites
《Acta Pharmaceutica Sinica B》2024年第9期4164-4173,共10页Kaixiang Zhu Lili Song Linyue Wang Lei Hua Ziyu Luo Tongyun Wang Bo Qin Shuofeng Yuan Xiaopan Gao Wenyi Mi Sheng Cui 
the following staff members and grant support.BL19U1 beamline of the National Facility for Protein Science in Shanghai(NFPS),BL17U1 beamline,and BL10U2 beamline at the Shanghai Synchrotron Radiation Facility.We thank the staff of PX III beamline at the Swiss Light Source,PaulScherrer Institute(Villigen Switzerland)for assistance in data collection.We thank the staffs from the Core Facility of National Institute of Pathogen Biology,Chinese Academy of Medical Sciences.This work was supported by National Key Research and Development Program of China(2023YFC2307803);Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2022-I2M-1-021,China);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2023-PT310-04,China);National Natural Science Foundation of China(82341095,82261160398,82072291,82272308);the Fundamental Research Funds for the Central Universities(3332021092,China).
Viruses often manipulate ubiquitination pathways to facilitate their replication and pathogenesis.CUL2ZYG11B known as the substrate receptor of cullin-2 RING E3 ligase,is bound by SARS-CoV-2 ORF10 to increase its E3 l...
关键词：SARS-CoV-2 ORF10 Crystal structure cullin-2 RING E3 ligase Drug design 
Clathrin light chains negatively regulate plant immunity by hijacking the autophagy pathway
《Plant Communications》2024年第8期172-188,共17页Hu-Jiao Lan Jie Ran Wen-Xu Wang Lei Zhang Ni-Ni Wu Ya-Ting Zhao Min-Jun Huang Min Ni Fen Liu Ninghui Cheng Paul A.Nakata Jianwei Pan Steven A.Whitham Barbara J.Baker Jian-Zhong Liu 
supported by grants from the National Natural Science Foundation of China(32170761,31571423 and 31371401 to J.-Z.L.and 91754104,31820103008,and 31670283 to J.P.);the Iowa State University Plant Sciences Institute and USDA National Institute of Food and Agriculture Hatch project 4308。
The crosstalk between clathrin-mediated endocytosis(CME)and the autophagy pathway has been reported in mammals;however,the interconnection of CME with autophagy has not been established in plants.Here,we report that t...
关键词：AUTOPHAGY clathrin light chain immunity clathrin-mediated endocytosis SENESCENCE cell death 
A buffer overflow detection and defense method based on RiSC-V instruction set extension
《Cybersecurity》2024年第2期28-43,共16页Chang Liu Yan-Jun Wu Jing-Zheng Wu Chen Zhao 
Strategic Priority Research Program of CAS(XDC05040000).
Buffer overflow poses a serious threat to the memory security of modern operating systems.It overwrites the con-tents of other memory areas by breaking through the buffer capacity limit,destroys the system execution e...
关键词：RISc-V Operating system security Buffer overflow Control flow hijacking Nx bit Xibop 
Artificial Nucleic Acid Tractor-Directed Simultaneous Depletion of Oncogenic Membrane Proteins Without Hijacking Proteolysis-Specific Actuator
《CCS Chemistry》2024年第2期439-449,共11页Zhen Zou Songlan Pan Qian Xue Ting Chen Ziyun Huang Bei Qing Pengfei Liu Conghui Zhao Yunlin Sun Erhu Xiong Ronghua Yang 
supported in part by the National Natural Science Foundation of China(grant nos.21705010,21735001,22274046,and 91853104);Hunan Provincial Natural Science Foundation of China(grant nos.2022JJ20038 and 2020JJ4409);the Scientific Research Fund of Hunan Provincial Education Department(grant no.20B032);Natural Science Foundation of Changsha City(grant no.kq2202189).
Targeted protein degradation(TPD)is an emerging tool for degrading proteins of interest,which affords an attractive modality for cancer therapy.However,the present TPD technologies must engage a proteolysis-specific a...
关键词：targeted protein degradation APTAMER epidermal growth factor receptor 2 LYSOSOME membrane proteins cancer therapy 
Skeletal muscle-directed gene therapy: hijacking the fusogenic properties of muscle cells
《Signal Transduction and Targeted Therapy》2023年第10期4428-4430,共3页Hildegard Buning Michael Morgan Axel Schambach 
A recent study published in Cell by the Millay lab reports on an elegant strategy to expand the repertoire of lentiviral(LV)vectors from being the main delivery tool for ex vivo gene therapy to an in vivo applicable v...
关键词：SKELETAL directed MUSCLE 
High-Risk LEO Satellite Network Path Detection Based on Spatial and Temporal Delay Anomaly Analysis被引量：1
《China Communications》2023年第7期57-71,共15页Tianyu Zhang Hewu Li Jun Liu Lu Lu Qian Wu Shaowen Zheng Zeqi Lai Yuanjie Li 
supported by National Key Research and Development Plan of China under Grant 2022YFB3105203;National Natural Science Foundation of China(62132009);key fund of National Natural Science Foundation of China(62272266);Tsinghua University-China Mobile Communications Group Co.,Ltd.Joint Institute;Zhongguancun Laboratory。
The gradual deployment of Low-Earth Orbit(LEO)mega constellations with inter-satellite links(ISLs)promises ubiquitous,low-latency,and high-throughput satellite network services.However,networked LEO satellites with IS...
关键词：LEO satellite networks route hijacking path verification risky path detection 
VenomAttack: automated and adaptive activity hijacking in Android
《Frontiers of Computer Science》2023年第1期187-204,共18页Pu SUN Sen CHEN Lingling FAN Pengfei GAO Fu SONG Min YANG 
supported by the National Natural Science Foundation of China (Grant Nos. 62072309 and 6171101225).
Activity hijacking is one of the most powerful attacks in Android. Though promising, all the prior activity hijacking attacks suffer from some limitations and have limited attack capabilities. They no longer pose secu...
关键词：ANDROID activity hijacking Android security mobile security 
Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p被引量：4
《Science Bulletin》2021年第18期1895-1905,M0004,共12页Yaojun Tong Jingyu Zhang Nuo Sun Xiang-Ming Wang Qi Wei Yu Zhang Ren Huang Yingying Pu Huanqin Dai Biao Ren Gang Pei Fuhang Song Guoliang Zhu Xinye Wang Xuekui Xia Xiangyin Chen Lan Jiang Shenlin Wang Liming Ouyang Ning Xie Buchang Zhang Yuanying Jiang Xueting Liu Richard Calderone Fan Bai Lixin Zhang Gil Alterovitzk 
supported by the National Key Research and Development Program of China (2020YFA0907800);the National Natural Science Foundation of China (31720103901);the “111” Project of China (B18022);the Fundamental Research Funds for the Central Universities (22221818014S);the Open Project Funding of the State Key Laboratory of Bioreactor Engineering,the Shandong Taishan Scholar Award,and the Novo Nordisk Foundation (NNF10CC1016517)。
Clinical use of antimicrobials faces great challenges from the emergence of multidrug-resistant pathogens. The overexpression of drug efflux pumps is one of the major contributors to multidrug resistance(MDR). Reversi...
关键词：Candida albicans BERBERINE MULTIDRUG-RESISTANCE Drug excretion transporter MITOCHONDRIA 
Hijacking host ubiquitination system by an Mtb protein to suppress anti-TB immunity
《Science Foundation in China》2020年第2期1-1,共1页
With the support by the National Natural Science Foundation of China,Chinese National Program on Key Basic Research Project,the Strategic Priority Research Program of the Chinese Academy of Sciences,Fundamental Resear...
关键词：IMMUNITY Clinical Basic 
Hijacking Plant Receptor by Nematode-Derived Peptide Mimics
《Molecular Plant》2020年第10期1351-1351,共1页Chun-Lin Shi 
The receptor-like kinase(RLK)FERONIA(FER)and its peptide ligands,called RALFs(Rapid ALkalinization Factors),function as signaling modules to control plant growth and development,stress responses,and plant immunity.Int...
关键词：PLANT OXYSPORUM DAMAGE 
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