MYELIN

作品数：165被引量：310H指数：9
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Is age-related myelinodegenerative change an initial risk factor of neurodegenerative diseases?
《Neural Regeneration Research》2026年第2期648-658,共11页Shuangchan Wu Jun Chen 
supported by grants from Guangdong Basic and Applied Basic Research Foundation,No.2021A1515110801(to SW);the National Natural Science Foundation of China,No.82301511(to SW);“Double First-Class”Construction Project of NPU,Nos.0515023GH0202320(to JC),0515023SH0201320(to JC)and 973 Program,No.2011CB504100(to JC).
Myelination,the continuous ensheathment of neuronal axons,is a lifelong process in the nervous system that is essential for the precise,temporospatial conduction of action potentials between neurons.Myelin also provid...
关键词：aging Alzheimer’s disease multiple sclerosis MYELIN myelin-axon metabolite crosstalk myelinodegeneration neurodegenerative disease OLIGODENDROCYTE Parkinson’s disease white matter 
Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics
《Neural Regeneration Research》2025年第11期3179-3192,共14页Pieter-Jan Serneels Julie D.De Schutter Lies De Groef Lieve Moons Steven Bergmans 
supported by KU Leuven Internal Funding(C3/21/012);the Research Foundation Flanders(FWO G092222N)(to LM)。
Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and oligodendrocytes.However,recent studies employing single-cell RNA sequencing techniques have ...
关键词：animal models DEMYELINATION fish MAMMALS multiple sclerosis MYELIN neurodegeneration OLIGODENDROCYTES oligodendroglial lineage REMYELINATION 
Crosstalk between androgen signaling and the chemokine receptor CXCR4:a novel strategy to promote myelin regeneration
《Neural Regeneration Research》2025年第9期2581-2582,共2页Marianne Bardy-Lagarde Narimène Asbelaoui Abdel Mouman Ghoumari 
supported by a grant from the French Multiple Sclerosis Society(ARSEP,Grant Number:R20163LL)(to AMG)。
Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterize...
关键词：MYELIN CXCR4 
Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke
《Neural Regeneration Research》2025年第7期2015-2028,共14页Jian Yang Jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li 
supported by the National Natural Science Foundation of China,Nos.82071307(to HL),82271362(to HL),82171294(to JW),82371303(to JW),and 82301460(to PX);the Natural Science Foundation of Jiangsu Province,No.BK20211552(to HL);Suzhou Medical Technology Innovation Project-Clinical Frontier,No.SKY2022002(to ZY);the Science and Education Foundation for Health of Suzhou for Youth,No.KJXW2023001(to XL)。
Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to remyelination.Failure of remyelination due to oligodendrocyte progenitor cell death can result in severe n...
关键词：BIOINFORMATICS bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing 
Harnessing therapeutic potential of induced pluripotent stem cell–derived endothelial cells for remyelination in the central nervous system
《Neural Regeneration Research》2025年第6期1715-1716,共2页Dan Ma Nona Pop 
supported by a grant from Aston University,Birmingham,UK (to DM)。
Myelin is the protective sheath surrounding nerve fibers, and its damage(demyelination) occurs in many central nervous system(CNS) diseases, including multiple sclerosis(MS), traumatic injury, neurodegenerative diseas...
关键词：MYELIN protective DISEASES 
Role of copper in central nervous system physiology and pathology
《Neural Regeneration Research》2025年第4期1058-1068,共11页Martina Locatelli Cinthia Farina 
Copper is a transition metal and an essential element for the organism,as alterations in its homeostasis leading to metal accumulation or deficiency have pathological effects in several organs,including the central ne...
关键词：ASTROCYTES central nervous system COPPER CUPRIZONE multiple sclerosis MYELIN neurodegenerative disorders 
Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion
《Neural Regeneration Research》2025年第4期1192-1206,共15页Tyler A.Smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner 
supported by grants from the Lone Star Paralysis Foundation,NIH R01NS081063;Department of Defense award W81XWH-19-2-0054 to GDB;supported by University of Wyoming Startup funds,Department of Defense grant W81XWH-17-1-0402;the University of Wyoming Sensory Biology COBRE under National Institutes of Health(NIH)award number 5P20GM121310-02;the National Institute of General Medical Sciences of the NIH under award number P20GM103432 to JSB。
Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal regeneration.Furthermore,such peripher...
关键词：allograft rejection AXOTOMY macrophage MYELIN nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration 
Oligodendroctyes:the forgotten players of diabetes pathophysiology
《Neural Regeneration Research》2024年第11期2349-2350,共2页Juan Antonio López-Villodres Beatriz García-Díaz 
funded by Instituto de Salud Carlos Ⅲ(ISCⅢ)through the project“CP20-0049”;co-funded by the European Union(to BGD).
Oligodendrocytes(OLs),glial cells that provide myelin sheaths to axons in the central nervous system(CNS),have a dual role.First,this myelin fatty cover around the axons protects the nerves and is crucial for the salt...
关键词：METABOLISM NERVES MYELIN 
The physiological role of the unfolded protein response in the nervous system
《Neural Regeneration Research》2024年第11期2411-2420,共10页Shuangchan Wu Wensheng Lin 
supported by grants from the National Institutes of Health,No.NS105689(to WL);the Department of Defense through the Multiple Sclerosis Research Program,No.W81XWH-22-1-0757(to WL).
The unfolded protein response(UPR)is a cellular stress response pathway activated when the endoplasmic reticulum,a crucial organelle for protein folding and modification,encounters an accumulation of unfolded or misfo...
关键词：MYELIN NEURON OLIGODENDROCYTE Schwann cell unfolded protein response 
Clustering of voltage-gated ion channels as an evolutionary trigger of myelin formation
《Neural Regeneration Research》2024年第8期1631-1632,共2页Henrike Ohm Simone Rey Christian Klambt 
supported by the Deutsche Forschungsgemeinschaft through funds to CK(SFB1348,B5,KI 588/29)。
Neurons carry apical dendrites that perceive information and a basal axon that transmits the computed information towards its to rgets.The axon originates at the axon hillock which is followed by the axon initial segm...
关键词：initiated CARRY POTASSIUM 
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