PRODRUGS

作品数：67被引量：100H指数：5
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相关领域：医药卫生化学工程更多>>
相关作者：张礼和谢璐佳郭颖卢俊峰徐靖源更多>>
相关机构：中国医学科学院北京协和医学院北京大学香港城市大学天津医科大学更多>>
相关期刊：《Nano-Micro Letters》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金天津市自然科学基金中国博士后科学基金教育部留学回国人员科研启动基金更多>>
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  • 期刊=Asian Journal of Pharmaceutical Sciencesx
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Fine-tuning the activation behaviors of ternary modular cabazitaxel prodrugs for efficient and on-target oral anti-cancer therapy
《Asian Journal of Pharmaceutical Sciences》2024年第2期188-203,共16页Mingyang Zhang Yifan Miao Can Zhao Tong Liu Xiyan Wang Zixuan Wang Wenxin Zhong Zhonggui He Chutong Tian Jin Sun 
supported by National Natural Science Foundation of China(No.82173766,82104109);Natural Science Foundation of Liaoning Province(2022-BS158);Liaoning Province Applied Basic Research Program(No.2022JH2/101300097);National Key R&D Program of China(No.2022YFE0111600).
The disulfide bond plays a crucial role in the design of anti-tumor prodrugs due to its exceptional tumor-specific redox responsiveness. However, premature breaking of disulfide bonds is triggered by small amounts of ...
关键词：Steric disulfide bond Triglyceride-like pr odrugs CABAZITAXEL Lymphatic transport Oral chemotherapy 
pH-triggered dynamic erosive small molecule chlorambucil nano-prodrugs mediate robust oral chemotherapy
《Asian Journal of Pharmaceutical Sciences》2023年第4期142-152,共11页Xin Liu Zhexiang Wang Xiaodie Ren Xinyang Chen Jinjin Tao Yuanhui Guan Xuefeng Yang Rupei Tang Guoqing Yan 
supported by the Anhui Engineering Technology Research Center of Biochemical Pharmaceutical(Bengbu Medical College);the National Natural Science Foundation of China(No.51803001);the Research Foundation of Education Department of Anhui Province of China(No.KJ2018ZD003,KJ2018A0006 and KJ2019A0015);the Academic and Technology Introduction Project of Anhui University(AU02303203).
Currently,the dynamic erosive small molecule nano-prodrug is of great demand for oral chemotherapy,owing to its precise structure,high drug loading and improved oral bioavailability via overcoming various physiologic ...
关键词：Nano-prodrugs pH sensitivity Size transition Oral chemotherapy 
Dynamic crosslinked polymeric nano-prodrugs for highly selective synergistic chemotherapy
《Asian Journal of Pharmaceutical Sciences》2022年第6期880-891,共12页Shi Wang Yining Song Jingge Ma Xinyang Chen Yuanhui Guan Hui Peng Guoqing Yan Rupei Tang 
supported by the Anhui Engineering Technology Research center of Biochemical Pharmaceutical(Bengbu Medical College)the National Natural Science Foundation of China(No.51803001);the Research Foundation of Education Department of Anhui Province of China(No.KJ2018ZD003,KJ2018A0006 and KJ2019A0015);the Academic and Technology Introduction Project of Anhui University(AU02303203)。
To achieve highly selective synergistic chemotherapy attractive for clinical translation,the precise polymeric nano-prodrugs(PPD-NPs)were successfully constructed via the facile crosslinking reaction between p H-sensi...
关键词：Nano-prodrugs Precise structure Size transition Amino protonation Synergistic chemotherapy 
Ocular prodrugs: Attributes and challenges被引量：1
《Asian Journal of Pharmaceutical Sciences》2021年第2期175-191,共17页Jagpreet kour Neha Kumari Bharti Sapra 
Ocular drug delivery is one of the most attention-grabbing and challenging endeavors among the numerous existing drug delivery systems.From a drug delivery point of view,eye is an intricate organ to investigate and ex...
关键词：BIOAVAILABILITY Corneal permeability ESTERASE Stability LIPOPHILICITY Ocular prodrugs 
Intra-Articular injection of acid-sensitive stearoxyl-ketal-dexamethasone microcrystals for long-acting arthritis therapy被引量：1
《Asian Journal of Pharmaceutical Sciences》2021年第2期213-221,共9页Yang Xu Ziqi Chen Zunkai Xu Yanyan Du Jianghao Han Xiaoyong Yuan Shubiao Zhang Shutao Guo 
We acknowledge financial support from the National Natural Science Foundation of China(51773098,81670817,81970772,21908019 and 21776044);Natural Science Foundation of Tianjin City of China(18JCYBJC28300);the Fundamental Research Funds for Central Universities(China).
Despite advances in treatment of chronic arthritis,there is still a strong need for the development of long-acting formulations that can enable local and sustained drug release at the inflamed tissues.In this work,we ...
关键词：MICROCRYSTALS DEXAMETHASONE PRODRUGS Long-acting formulations ARTHRITIS 
A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates被引量：1
《Asian Journal of Pharmaceutical Sciences》2019年第6期631-639,共9页Yixin Sun Dongyang Zhao Gang Wang Qikun Jiang Mengran Guo Qiming Kan Zhonggui He Jin Sun 
financially Supported by National Nature Sci-ence Foundation of China(No.81773656,U1608283,81573497);Liaoning Revitalization Talents Program,No XLYC1808017,Key projects of Technology bureau in Shenyang,No18400408;Key projects of Liaoning Province Department of Education,No.2017LZD03
Monocarboxylate transporter 1(MCT1)is responsible for oral absorption of short-chain monocarboxylic acids from small intestine,hence,it’s likely to serve as an ideal design target for the development of oral prodrugs...
关键词：5-FLUOROURACIL PRODRUGS Monocarboxylate TRANSPORTER 1 Permeability ORAL bioavailability 
Synthesis, characterization and in vivo evaluation of honokiol bisphosphate prodrugs protects against rats’ brain ischemia-reperfusion injury
《Asian Journal of Pharmaceutical Sciences》2019年第6期640-648,共9页Gaojie Xu Renghan Dong Jin Liu Li Zhao Yan Zeng Xiaofan Xiao Jinglin An Sheng Huang Yueling Zhong Bing Guang Tai Yang 
supported by the Scientific Research Fund of the National Natural Science Foundation of China ( 81201668 );Chengdu Science and Technology Bureau ( 2015HM01-00506-SF , 2018-YF05-00454-SN );Scientific Research Fund of the Sichuan Provincial Education Department (17CZ0011, 17ZA0109);the Scientific Research Fund of Chengdu Medical College (CYCG15-01)
Honokiol(HK)usage is greatly restricted by its poor aqueous solubility and limited oral bioavailability.We synthesized and characterized a novel phosphate prodrug of honokiol(HKP)for in vitro and in vivo use.HKP great...
关键词：Phosphate PRODRUG HONOKIOL PHARMACOKINETICS Focal cerebral ISCHEMIA-REPERFUSION 
The amino acid transporter SLC6A14 in cancer and its potential use in chemotherapy被引量：8
《Asian Journal of Pharmaceutical Sciences》2014年第6期293-303,共11页Yangzom D.Bhutia Ellappan Babu Puttur D.Prasad Vadivel Ganapathy 
Tumor cells have an increased demand for glucose and amino acids to support their rapid growth,and also exhibit alterations in biochemical pathways that metabolize these nutrients.Transport across the plasma membrane ...
关键词：Essential amino acids Glutamine addiction Amino acid transporters SLC6A14 PRODRUGS Cancer therapy 
Prodrugs incorporated into nanotechnology-based drug delivery systems for possible improvement in bioavailability of ocular drugs delivery被引量：3
《Asian Journal of Pharmaceutical Sciences》2013年第4期207-217,共11页Tiantian Ye Kun Yuan Wenji Zhang Shuangshuang Song Fen Chen Xinggang Yang Shujun Wang Jianwei Bi Weisan Pan 
special construction projects fund which belongs to“Taishan Scholar-Pharmacy Specially Recruited Experts”.
Numerous systems have been designed during the past three decades to improve bioavailability of ophthalmic drug delivery,including:ocular prodrugs and nanotechnology-based drug delivery system.The former can improve t...
关键词：Ocular/ophthalmic drug delivery PRODRUGS NANOCARRIERS Penetration Precorneal retention BIOAVAILABILITY 
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