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ANTITUMOR: 作品数：470被引量：1206H指数：15; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：明艳林陈良华刘韶松齐宪荣李润涛更多>>; 相关机构：北京大学天津医科大学中国药科大学福建省亚热带植物研究所更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划北京市自然科学基金更多>>

Enantioselective Synthesis of Benzimidazole Atropisomers Featuring a N-N Axis: 《Chinese Journal of Chemistry》2024年第7期711-718,共8页Fang-Bei Ge Qi-Kun Yin Chuan-Jun Lu Xuan Xuan Jia Feng Ren-Rong Liu; supported by Taishan Scholar Youth Expert Program in Shandong Province (tsqn201909096);National Natural Science Foundation of China (22371152);Shandong Provincial Natural Science Foundation Project (ZR2023JQ006,ZR2022MB021);the startup fund from Qingdao University.; Atroposelective synthesis of N-N atropisomers is an emerging area but remains underexplored;in particular,the synthesis of N-N benzimidazole atropisomers is still unprecedented.Herein,the first enantioselective synthe...; 关键词：Asymmetric synthesis ATROPISOMERISM PALLADIUM BENZIMIDAZOLE ANTITUMOR

A Novel Vascular Disrupting Agents Noncovalent Polymeric Nanomedicine:Significantly Increased Antitumor Therapeutic Efficiency被引量：2: 《Chinese Journal of Chemistry》2022年第12期1447-1456,共10页Jianlin Lv Yajun Xu Yue Huang Haiyang Yu Zhaohui Tang; the National Natural Science Foundation of China(Nos.52025035,52103195).; This work was supported by the National Natural Science Foundation of China(Nos.52025035,52103195).The comprehensive graphic content and graphic abstract were created with BioRender.com by coauthors.; 关键词：Vascular disrupting agents Antitumor agents SELF-ASSEMBLY Cancer Nanoparticles

A Modular Synthesis of Antitumor Macrolide (-)-Lasonolide A被引量：1: 《Chinese Journal of Chemistry》2020年第7期725-736,共12页Lin Yang Zuming Lin Kuan Zheng Luyao Kong Ran Hong; the Drug Innovation Major Project(2018ZX09711001-005);the National Natural Science Foundation of China(91856202);the National Key R&D Program of China(2019YFA09005000);the Strategic Priority Research Program(XDB20000000);the Key Research Program of Frontier Sciences(QYZDYSSWSLH026)of the Chinese Academy of Sciences is highly appreciated.We also thank Jie Sun(SIOC,CAS)for the X-ray analysis.; Lasonolide A was identified as a potent antitumor macrolide towards various cancer cell lines.The two tetrahydropyrans bearing multiple stereogenic centers as well as the polyvene linkage attracted a dozen synthetic r...; 关键词：ALDEHYDES LINKAGE REAGENT

Synthesis and Antitumor Activity Evaluation of Pyrimidine Analogues Bearing Urea Moiety: 《Chinese Journal of Chemistry》2014年第5期443-447,共5页Kunpeng Shao Xuyao Zhang Xiaosong Zhang Dengqi Xue Liying Ma Qiurong Zhang Hongmin Liu; This work was supported by the National Natural Science Foundation of China(Nos.81172937,U1204206);China Postdoctoral Science Foundation(Nos.20100480857,201104402);New Teachers’Fund for Doctor Stations,Ministry of Education(No.20114101120013).; A series of 4-anilino-6-phenylpyrimidines containing urea moiety were synthesized and the structures of all products were confirmed by^(1)H NMR,^(13)C NMR and HRMS.The antiproliferative activities of these compounds w...; 关键词：SYNTHESIS PYRIMIDINE UREA ANTITUMOR

Synthesis of 7-Triazole-substituted Camptothecin via Click Chemistry and Evaluation of in vitro Antitumor Activity被引量：1: 《Chinese Journal of Chemistry》2014年第2期157-162,共6页Lei Wang Wei Yuan Jie Zhang Linjiang Tong Yu Luo Yi Chen Wei Lu Qingqing Huang; This work was supported by the grants of The National Natural Science Foundation of China(Nos.81172936,21102046),and grants of The Fundamental Research Funds for the Central Universities.We also thank the Laboratory of Organic Functional Molecules,the Sino-French Institute of ECNU for support.; Camptothecin(CPT)is a natural topoisomerase I inhibitor with powerful antineoplastic activity against colorectal,breast,lung and ovarian cancers.To discover more potent antitumor agents,a series of new CPT derivatives...; 关键词：CAMPTOTHECIN 7-triazole-substituted camptothecin click chemistry ANTITUMOR

Synthesis, Antitumor and Apoptosis Inducing Activities of Novel 5-Fluorouracil Derivatives of Rare Earth （Sm, Eu） Substituted Polyoxometalates被引量：3: 《Chinese Journal of Chemistry》2012年第7期1589-1593,共5页冯长根甘强刘霞何洪优; Two novel 5-fluorouracil derivatives of rare earth （Sm, Eu） substituted polyoxometalates, K9（C4H4FN2O2）2- Sm（PW11O39）2·11H2O （FSmPW） and KgH（C4H4FN2O2）Eu（PW11O39）2＊11 H2O （FEuPW） were synthesized and c...; 关键词：POLYOXOMETALATES rare earth HeLa HEPG-2 ANTITUMOR APOPTOSIS

Synthesis of Analogues of the Antitumor (1→6)-Branched (1→3)-Glucohexaose被引量：2: 《Chinese Journal of Chemistry》2004年第5期460-466,共7页曾佑林张建军孔繁祚; Project supported by Chinese Academy of Sciences (No. KZCX3-J-08) and the National Science Foundation of China (Nos. 30070185 and 39970964).; b-D-Glcp-(13)-[b-D-Glcp-(16)-]a-D-Manp-(13)-b-D-Glcp-(13)-[b-D-Glcp-(16)-]D-Glcp (18) and b-D-Glcp-(13)-[b-D-Glcp-(16)-]a-D-Manp-(13)-b-D-Glcp-(13)-[b-D-Glcp-(16)-]b-D-Glcp-D-(13)-Glcp-1OMe (29) were synthesized as th...; 关键词：OLIGOSACCHARIDE trichloroacetimidate regio- and stereoselective synthesis

Structural Elucidation and Antitumor Activity of Polysaccharide AMP-1 from Atractylodis macrocephalae K.被引量：1: 《Chinese Journal of Chemistry》2003年第1期87-90,共4页单俊杰柯炜邓军娥田庚元; A polysaccharide named as AMP-1 was isolated from the root of Atractylodis macrocephalae Koidz, and purified by ethanol fractionation and gel filtration. The homogeneity of AMP-1 was determined by HPLC and capillary...; 关键词：STRUCTURE POLYSACCHARIDE Atractylodis macrocephalae K. ANTITUMOR

Studies on Synthesis and Antitumor Activity of Phosphorylated Achyranthes bidentata Polysaccharide (P-AbPS)被引量：21: 《Chinese Journal of Chemistry》2002年第11期1406-1410,1133,共5页陈晓明张健田庚元; theMinistryofScienceandTechnology ,China (No .970 2 110 0 6 4 4 ); The synthesis of phosphorylated Achyranthes bidentata polysaccharide (P-AbPS) was reported based on different strategies. The P-AbPS with high degree of substitution (D.S. > 0.5) was obtained when phosphorus oxychlori...; 关键词：PHOSPHORYLATION POLYSACCHARIDE Achyranthes bidentata ANTITUMOR

Synthesis of a Mimicking Hybrid of Annonaceous Acetogenin with Steroid for Antitumoral Activity Investigation: 《Chinese Journal of Chemistry》2002年第11期1393-1400,1133,共8页蒋晟吴毓林姚祝军; theMajorStateBasicResearchDevelopmentProgram (No .G2 0 0 0 0 775 0 2 ) ,ChineseAcademyofSciencesandShanghaiMunicipalCommissionofScienceandTechnology; The first example of annonaceous acetogenin-steroid hybrid was synthesized for the antitumoral study.; 关键词：annonaceous acetogenin STEROID MIMICRY ANTITUMOR

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