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PNPLA3 and TM6SF2 polymorphisms in Brazilian patients with nonalcoholic fatty liver disease
《World Journal of Hepatology》2020年第10期792-806,共15页Quelson Coelho Lisboa Mateus Jorge Nardelli Patrícia de Araújo Pereira Débora Marques Miranda Stephanie Nunes Ribeiro Raissa Soares Neves Costa Camila Azevedo Versiani Paula Vieira Teixeira Vidigal Teresa Cristina de Abreu Ferrari Claudia Alves Couto 
Supported by Fundação de AmparoàPesquisa do Estado de Minas Gerais,No.APQ-02233-14.
BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is becoming the most common chronic liver disease worldwide,with significant morbidity associated with nonalcoholic steatohepatitis(NASH).Genome-wide association studi...
关键词：Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Genetic variation Single nucleotide polymorphism GENOTYPE Brazil FIBROSIS 
Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites被引量：3
《World Journal of Hepatology》2018年第1期124-133,共10页Edilmar Alvarado-Tapias Carlos Guarner-Argente Elida Oblitas Elisabet Sánchez Silvia Vidal Eva Román Mar Concepción Maria Poca Cristina Gely Oana Pavel Juan Camilo Nieto Cándido Juárez Carlos Guarner Germán Soriano 
Supported by(partially)from the Instituto de Salud CarlosⅢ,Madrid,Spain,No.PI0900357;cofinanced by Fondos FEDER(Fondo Europeo de Desarrollo Regional);“Una manera de hacer Europa”,European Union,and CERCA Programme,Generalitat de Catalunya;Silvia Vidal was supported by Fondo de Investigaciones Sanitarias(FIS);a participant in the Program for Stabilization of Investigators of the Direcciód’Estrategia i Coordinaciódel Departament de Salut,Generalitat de Catalunya;Edilmar Alvarado-Tapias is a recipient of a“Río Hortega”fellowship grant from the Instituto de Salud CarlosⅢ,No.CM16/00133
AIM To assess the relationship between the presence of toll-like receptor 4(TLR4) polymorphisms and bacterial infections in cirrhotic patients with ascites. METHODS We prospectively included consecutive patients with ...
关键词：CIRRHOSIS Genetic POLYMORPHISMS TOLL-LIKE receptor 4 BACTERIAL INFECTIONS ASCITES 
Predictive potential of IL-28B genetic testing for interferon based hepatitis C virus therapy in Pakistan: Current scenario and future perspective被引量：1
《World Journal of Hepatology》2016年第26期1116-1118,共3页Muhammad Sohail Afzal 
In Pakistan which ranked second in terms of hepatitis C virus(HCV) infection, it is highly needed to have an established diagnostic test for antiviral therapy responseprediction. Interleukin 28B(IL-28B) genetic testin...
关键词：Diagnostics HEPATITIS C virus INTERFERON THERAPY POLYMORPHISMS IL-28B Genetic testing Pakistan 
Polymorphisms of folate metabolism genes in patients with cirrhosis and hepatocellular carcinoma
《World Journal of Hepatology》2016年第29期1234-1243,共10页Nathália Perpetua Peres Ana Lívia Silva Galbiatti-Dias Marcia Maria Urbanin Castanhole-Nunes Renato Ferreira da Silva Erika Cristina Pavarino Eny Maria Goloni-Bertollo Mariangela Torreglosa Ruiz-Cintra 
the Faculdade de Medicina de Sao Jose do Rio Preto,FAMERP and Medical School Foundation;FUNFARME for their institutional support;UPGEM-Genetics and Molecular Biology Research Unit
AIM To evaluated the association of the risk factors and polymorphisms in MTHFR C677 T, MTHFR A1298 C, MTR A2756 G and MTRR A66 G genes.METHODS Patients with cirrhosis(n = 116), hepatocellular carcinoma(HCC)(n = 71) a...
关键词：POLYMORPHISM Folate metabolism Liver cirrhosis Hepatocellular carcinoma 
Insulin resistance and steatosis in HBV-HCV co-infected patients: Role of PNPLA3 polymorphisms and impact on liver fibrosis progression被引量：2
《World Journal of Hepatology》2014年第9期677-684,共8页Rosa Zampino Adriana Boemio Aldo Marrone Luciano Restivo Maria Chiara Fascione Riccardo Nevola Luigi Elio Adinolfi Nicola Coppola Carmine Minichini Mario Starace Evangelista Sagnelli Grazia Cirillo Emanuele Miraglia del Giudice Maria Stanzione Emanuele Durante-Mangoni Giovanna Salzillo 
Supported by Regione Campania,Italy
AIM:To evaluate steatosis,insulin resistance(IR)and patatin-like phospholipase domain-containing 3(PNPLA3) and their relation to disease progression in hepatitis B and C viruses(HCV-HBV) coinfected patients.METHODS:Th...
关键词：STEATOSIS Insulin resistance Hepatitis B and C viruses CO-INFECTION Patatin-like PHOSPHOLIPASE domain-containing 3 Liver fibrosis 
IL-28B polymorphisms and treatment response in hepatitis C virus patients with persistently normal alanine aminotransferase被引量：2
《World Journal of Hepatology》2013年第11期635-641,共7页Tatsuo Miyamura Tatsuo Kanda Masato Nakamura Xia Jiang Shuang Wu Shingo Nakamoto Shigeru Mikami Nobuo Takada Fumio Imazeki Osamu Yokosuka 
Supported by Grants for Scientific Research from the Ministry of Education,Culture,Sports,Science,and Technology,Japan;Grants from the Ministry of Health,Labour and Welfare of Japan
AIM:To examine the association between the interleukin 28B(IL-28B)genotype and treatment response in hepatitis C virus(HCV)-infected patients with persistently normal alanine aminotransferase(PNALT).METHODS:We compar...
关键词：Hepatitis C virus INTERLEUKIN 28B PERSISTENT normal ALANINE AMINOTRANSFERASE levels Standard of care Treatment response 
Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury被引量：17
《World Journal of Hepatology》2013年第10期541-549,共9页Clarice Silvia Taemi Origassa Niels Olsen Saraiva Cmara 
Supported by Brazilian Foundation-FAPESP(Fundao deapoio à pesquisa do Estado de So Paulo),No.07/07139-3,10/02024-6 and CNPq
The activation of heme oxygenase-1(HO-1) appears to be an endogenous defensive mechanism used by cells to reduce inflammation and tissue damage in a number of injury models. HO-1, a stress-responsive enzyme that catab...
关键词：HEME OXYGENASES BILIRUBIN Hepatitis C KUPFFER cells POLYMORPHISMS Immunoregulatory Hypoxia Liver ISCHEMIA 
Relationship between interleukin 18 polymorphisms and susceptibility to chronic hepatitis B virus infection被引量：4
《World Journal of Hepatology》2012年第3期105-109,共5页Na Li   Yu-Feng Gao   Tian-Chen Zhang   Ping Chen   Xu Li   Fei Su 
Supported by the Grants from the National Natural Science Foundation of China,No.81072342;the Foundation of Pre-973 Program Projects,No.2009CB526411
AIM: To identify the relationship between the tagging single nucleotide polymorphism sites (tagSNPs) of the Interleukin-18 (IL-18) gene and genetic susceptibility to chronic hepatitis B virus infection in Chinese pati...
关键词：Hepatitis B virus Interleukin 18 tagSNP Genetic susceptibility 
Polymorphisms in programmed death-1 gene are not associated with chronic HBV infection in Chinese patients被引量：3
《World Journal of Hepatology》2011年第3期72-78,共7页Feng Lv,Yu-Feng Gao,Zhen-Huan Zhang,Ming-Fang Cui,Shu-Ling Xia,Xu Li,Hua-Fa Yin,Department of Infectious Diseases,the First Affiliated Hospital,Anhui Medical University,Hefei 230022,Anhui Province,China Tian-Chen Zhang,Fa-Ming Pan,Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,Hefei 230032,Anhui Province,China Author 
Supported by the Grants from the National Natural Science Foundation of China, No.30700698 and 30771907;the Foundation of Pre-973 Program Projects, No. 2009CB526411
AIM:To investigate the association between the programmed death-1(PD-1) polymorphisms and genetic susceptibility of chronic hepatitis B virus(HBV) infection in Chinese patients.METHODS:Two single nucleotide polymorphi...
关键词：Programmed death-1 HEPATITIS B virus Single NUCLEOTIDE POLYMORPHISM Genetic ASSOCIATION study FAMILY-BASED ASSOCIATION test 
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