supported by the Major Project of Hubei Hongshan Laboratory(2022hszd004);the National Cotton Production System,Ministry of Agriculture and Rural Affairs of China(CARS-15-04);the National Key R&D Program of China(2022YFF1003502);the National Natural Science Foundation of China(32072024).
High-temperature(HT)stress causes male sterility in crops,thus decreasing yields.To explore the possible contribution of histone modifications to male fertility under HT conditions,we defined the histone methylation l...
supported by the National Key Research and Development Program of China (Grant No. 2018YFD1000300);the National Natural Science Foundation of China (Grant No. 32025032);the Grape Breeding Project of Ningxia (Grant No. NXNYYZ202101-04);Major Program of Technological Innovation in Hubei Province (Grant No. 2019ABA093).
Histone H3 lysine 27 trimethylation(H3K27me3) is a histone modification associated with transcriptional repression. However, insights into the genome-wide pattern of H3K27me3 in grapevines are limited. Here, anti-H3K2...
supported by National Institutes of Health(NIH)grants(No.R01 ES031822,R01 ES028335,and R01 ES028263);Wayne State University Research Enhancement grant,and Research Startup fund of the Stony Brook University to FC。
To the Editor:Environmental arsenic is a known human carcinogen that is associated with cancers in lung,liver,skin,breast,bladder,kidney,prostate,etc.1 However,the underpinnings of ma-lignant transformation of the nor...
the National Natural Science Foundation of China(Grant Nos.32170192 and 32000103);Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding(Grant No.2021C02064);Key Research and Development Project of China National Rice Research Institute(Grant No.CNRRI-2020-04);the Chinese Academy of Agricultural Sciences under the‘Elite Youth’Program and the Agricultural Sciences and Technologies Innovation Program.
Polycomb repressive complex 2(PRC2)contributes to catalyze the methylation of histone H3 at lysine 27 and plays vital roles in transcriptional silencing and growth development in various organisms.In Magnaporthe oryza...
Supported by the USA-Israel Binational Science Foundation,No.2013034;the Israel Science Foundation administered by the Israel Academy of Science,No.1235/17;the Jacki and Bruce Barron Cancer Research Scholars’Program;City of Hope and the Israel Cancer Research Fund,No.87735611.
The mammalian protein kinase C-interacting cousin of thioredoxin(PICOT;also termed glutaredoxin 3)is a multi-domain monothiol glutaredoxin that is involved in a wide variety of signaling pathways and biological proces...
supported by grants from the National Natural Science Foundation of China(31970578,31872812,31671335,and 31600046);the Natural Science Foundation of Hubei Province(2017CFA066).
Cells need to coordinate gene expression with their metabolic states to maintain cell homeostasis and growth.However,how cells transduce nutrient availability to appropriate gene expression response via histone modifi...
supported by the National Key Research and Development Program of China (2016YFA0500801);the 973 Program (2011CB812600) from the Chinese Ministry of Science and Technology (to X.J.H.);the National Natural Science Foundation of China (31370317 and 31571584 to B.W.)
LHP1 mediates recruitment of the PRC2 histone methyltransferase complex to chromatin and thereby facilitates maintenance of H3K27me3 on FLC, a key flowering repressor gene. Here, we report that the PWWP domain protei...
We thank the staff of beamline 17U at the Shanghai Synchrotron Radiation Facility for technical support during data collection and Y. Y. Chen for help with the ITC assay. This work was supported by the National Natural Science Foundation of China (Grant Nos. 30900230 and 31021062) and the National Basic Research Pro- gram (973 Program) (No. 2011CBA00902). Hongmei Zhang, Mei Li, Yu Gao, Chenjun Jia, Xiaowei Pan, Peng Cao, Xuelin Zhao, Jiping Zhang, and Wenrui Chang declare that they have no conflict of interest. This article does not contain any studies with human or animal subjects performed by the any of the authors.
Dear Editor, The methylation modifications of histone 3 lysine 4 (H3K4) have essential effects on biological processes including gene expression and transcription, cell cycle progression, and DNA repair. From yeast ...
The effects of epigenetic modification on the differentiation of islet cells and the expression of associated genes(Pdx-1,Pax4,MafA,and Nkx6.1,etc) were investigated.The promoter methylation status of islet differen...
Supported by National Natural Science Foundation of China (30130026, U0632005, 30721063);National Basic Research Program of China (973 Program) (2011CB964803);National Laboratory of Medical Molecular Biology grant (2060204);Beijing municipal government grant (YB20081002301)
Objective To investigate whether α-hemoglobin stabilizing protein (AHSP), the α-globin-specific molecular chaperone, is regulated by erythroid transcription factor NF-E2. Methods We established the stable cell line ...