It is textbook knowledge that the thymus is the factory of naïve T cells.Counterintuitively,naïve T cell production by the thymus is well-known to atrophy during acute inflammation[1].Pérez and colleagues in this iss...
Background: Sagittal plane placement of the tibial component in total knee replacement (TKR) has important implications for maximizing the range of flexion motion, allowing collateral ligaments to function more normal...
supported by S&T Program of Hebei,China(Grant Number 21377754D);the 2021 Hebei Provincial Governmentfunded Clinical Medicine Talents Training Project(Grant Number 2021-99)。
Background:Prognosis of multiple myeloma(MM)patients with extramedullary disease(EMD)remains poor.T cell dysfunction and an immunosuppressive environment have been reported in the bone marrow(BM)of MM patients.However...
BACKGROUND Extramedullary blast crisis in chronic myeloid leukemia(CML)is an uncommon occurrence of leukemic blast infiltration in regions other than the bone marrow.Malignant infiltration of the serosal membranes sho...
BACKGROUND Extramedullary multiple myeloma(MM)(EMM)is a rare and aggressive subentity of MM that can be present at diagnosis or develop anytime during the disease course.There is a paucity of data on the clinical char...
the National Natural Science Foundation of China(Nos.81800201 and 81872322);the Zhejiang Key Research and Development Project(No.2020C03014);the Key Project of Zhejiang Provincial Natural Science Foundation of China(No.LZ22H160009)。
Multiple myeloma(MM)is a common malignant hematological tumor in adults,which is characterized by clonal malignant proliferation of plasma cells in the bone marrow and secretion of a large number of abnormal monoclona...
Supported by the Jiangxi“5511”Science and Technology Innovation Talent Project,No.20171BCB18003。
BACKGROUND Chronic myeloid leukemia(CML)is a malignant hematologic malignancy that can progress to blast phase with a myeloid or lymphoid phenotype.Some patients with CML can also progress to blast crisis phase;howeve...
National Natural Science Foundation of China(No. 82070223);Social Development Project of Jiangsu Science and Technology Plan(No. BE2022810)
To the Editor:Multiple myeloma(MM),the second most common hematological malignancy,is caused by clonal proliferation of plasma cells and presents characteristics including anemia,bone pain,renal insufficiency,and hype...
Supported by a Clinical Research Grant from Pusan National University Hospital(2020).
BACKGROUND A malignant melanotic nerve sheath tumor(MMNST),previously known as a melanotic schwannoma,is a rare variant of a peripheral nerve sheath tumor composed of Schwann cells with melanotic differentiation.Only ...
This work was supported by the Research Support of the University of Rijeka:grant No.918.10.0104。
Extramedullary disease(EMD)of multiple myeloma(MM)can present as paraskeletal(paraosseous)plasmocytoma(PP)that arise from skeletal focal lesions or extramedullary plasmacytomas(EMP)that derive from hematogenous spread...