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SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM: 《Science China(Life Sciences)》2025年第3期793-808,共16页Hongguo Duan Shuang Wang Wen-Jie Shu Yongjia Tong Hai-Zhen Long Guohong Li Hai-Ning Du Meng-Jie Zhao; supported by the National Key Research and Development program of China(2023YF0913403);the National Natural Science Foundation of China(32200584,31971231);the Fundamental Research Funds for the Central Universities(2042022dx0003,2042022kf1048);the China Postdoctoral Science Foundation(2021M702526).; The minichromosome maintenance complex(MCM)DNA helicase is an important replicative factor during DNA replication.The proper chromatin loading of MCM is a key step to ensure replication initiation during S phase.Becau...; 关键词：histidine methylation SETD3 DNA replication MCM replication origin firing

Hi-Tag:a simple and efficient method for identifying protein-mediated long-range chromatin interactions with low cell numbers: 《Science China(Life Sciences)》2024年第5期1027-1034,共8页Xiaolong Qi Lu Zhang Qiulin Zhao Peng Zhou Sai Xian Zhang Jingjin Li Zhuqing Zheng Yue Xiang Xueting Dai Zhe Jin Yaobang Jian Xinyun Li Liangliang Fu Shuhong Zhao; supported by the National Natural Science Foundation of China(32221005);the Earmarked Fund for CARS(CARS-35);the National Natural Science Foundation of China Outstanding Youth(32125035);Major Project of Hubei Hongshan Laboratory(2021hszd003)。; Protein-mediated chromatin interactions can be revealed by coupling proximity-based ligation with chromatin immunoprecipitation.However,these techniques require complex experimental procedures and millions of cells pe...; 关键词：Hi-Tag chromatin interactions transposase tagmentation chromatin proximity ligation low cell numbers

KLF4 facilitates chromatin accessibility remodeling in porcine early embryos被引量：3: 《Science China(Life Sciences)》2024年第1期96-112,共17页Wei Zhu Guowei Bu Ruifeng Hu Jixiang Zhang Lianyong Qiao Kai Zhou Tingting Wang Qiao Li Jingjing Zhang Linhui Wu Yali Xie Taotao Hu Shichun Yang Jiaqi Guan Xiaoyu Chu Juanjuan Shi Xia Zhang Falong Lu Xin Liu Yi-Liang Miao; This work was supported by the National Natural Science Foundation of China(31902161);the National Key Research and Development Program of China(2022YFD1302201,2018YFA0107001);Strategic Priority Research Program of Chinese Academy of Sciences(XDA24020203);Key Research and Development Program of Hubei Province(2021BBA221);Major Project of Hubei Hongshan Laboratory(2021hszd003);Foundation of Key Laboratory of Animal Genetics,Breeding and Reproduction in the Plateau Mountainous Region,Ministry of Education,Guizhou University(QJHKY[2022]373).; Chromatin accessibility remodeling driven by pioneer factors is critical for the development of early embryos.Current studies have illustrated several pioneer factors as being important for agricultural animals,but wh...; 关键词：porcine embryos liDNase-seq chromatin accessibility KLF4 MITOCHONDRION lipid droplets

Developmental dynamics of the single nucleus regulatory landscape of pig hippocampus: 《Science China(Life Sciences)》2023年第11期2614-2628,共15页Siyu Yang Dong Chen Lei Xie Xiaoxiao Zou Yanyuan Xiao Lin Rao Tianxiong Yao Qing Zhang Liping Cai Fei Huang Bin Yang Lusheng Huang; supported by the National Natural Science Foundation of China(32160781).; The hippocampus is a brain region associated with memory,learning and spatial navigation,its aging-related dysfunction is a common sign of Alzheimer’s disease.Pig is a good model for human neurodegenerative disease,b...; 关键词：HIPPOCAMPUS PIG chromatin accessibility gene expression NUCLEI accessible chromatin regions development

Trim28 citrullination maintains mouse embryonic stem cell pluripotency via regulating Nanog and Klf4 transcription: 《Science China(Life Sciences)》2023年第3期545-562,共18页Yaguang Zhang Xiaowen Wan Lei Qiu Lian Zhou Qing Huang Mingtian Wei Xueqin Liu Sicheng Liu Bo Zhang Junhong Han; supported by the National Natural Science Foundation of China(31972884);the National Key Research and Development Program of China(2018YFC1312300);the National Clinical Research Center for Geriatrics(Z20201007);1·3·5 Project for Disciplines of Excellence,West China Hospital(ZYGD18003);the Postdoctoral Research Project,West China Hospital,Sichuan University(18HXBH068);the Natural Science Foundation of Sichuan,China(2022NSFSC1424)。; Protein citrullination,including histone H1 and H3 citrullination,is important for transcriptional regulation,DNA damage response,and pluripotency of embryonic stem cells(ESCs).Tripartite motif containing 28(Trim28),a...; 关键词：CITRULLINATION CHROMATIN embryonic stem cell PLURIPOTENCY Trim28

Short telomeres impede germ cell specification by upregulating MAPK and TGFβsignaling被引量：2: 《Science China(Life Sciences)》2023年第2期324-339,共16页Chenglei Tian Dai Heng Nannan Zhao Linlin Liu Xiaoyan Sheng Jiyu Chen &Lin Liu; supported by China National Key R&D Program(2018YFA0107002,2018YFC1003004);the National Natural Science Foundation of China(32030033,31430052)。; Functional telomeres protect chromosome ends and play important roles in stem cell maintenance and differentiation. Short telomeres negatively impact germ cell development and can contribute to age-associated infertil...; 关键词：TELOMERE primordial germ cell MAPK TGFΒ chromatin accessibility

Mechanisms of chromatin-based epigenetic inheritance被引量：7: 《Science China(Life Sciences)》2022年第11期2162-2190,共29页Wenlong Du Guojun Shi Chun-Min Shan Zhiming Li Bing Zhu Songtao Jia Qing Li Zhiguo Zhang; the National Natural Science Foundation of China(31725015,31830048 to Q.L.and 32000417 to W.D.);the Beijing Outstanding Young Scientist Program(BJJWZYJH01201910001005 to Q.L.);the National Key Research and Development Project of China(2019YFA0508903 to Q.L.);the China Postdoctoral Science Foundation(2020M670487 to W.D.);the Chinese Academy of Sciences(XDB 37010100 and QYZDY-SSW-SMC031 to B.Z.);the K.C.Wong educational foundation(GJTD-2020-06 to B.Z.);the National Institutes of Health(R35 GM126910 to S.J.and R35 GM115018 to Z.Z.)。; Multi-cellular organisms such as humans contain hundreds of cell types that share the same genetic information(DNA sequences),and yet have different cellular traits and functions.While how genetic information is passe...; 关键词：epigenetic inheritance histone modification DNA methylation histone deposition DNA replication

Individual variation in buffalo somatic cell cloning efficiency is related to glycolytic metabolism: 《Science China(Life Sciences)》2022年第10期2076-2092,共17页Chan Luo Zhiqiang Wang Jinling Wang Feng Yun Fenghua Lu Jiayuan Fu Qingyou Liu Deshun Shi; supported by the National Natural Science Foundation of China(31772597,31972996,31902125);Guangxi Natural Science Foundation(2017GXNSFAA198311)。; Mammalian individuals differ in their somatic cell cloning efficiency,but the mechanisms leading to this variation is poorly understood.Here we found that high cloning efficiency buffalo fetal fibroblasts(BFFs)display...; 关键词：BUFFALO cloning efficiency chromatin openness histone acetylation glycolytic metabolism

Exogenous artificial DNA forms chromatin structure with active transcription in yeast被引量：1: 《Science China(Life Sciences)》2022年第5期851-860,共10页Jianting Zhou Chao Zhang Ran Wei Mingzhe Han Songduo Wang Kaiguang Yang Lihua Zhang Weigang Chen Mingzhang Wen Cheng Li Wei Tao Ying-Jin Yuan; supported by the National Key Research and Development Program of China (2121YFA0909300);the National Natural Science Foundation of China (31861143017,21621004;31901019);the China Postdoctoral Science Foundation(2021M692389)。; Yeast artificial chromosomes(YACs) are important tools for sequencing,gene cloning,and transferring large quantities of genetic information.However,the structure and activity of YAC chromatin,as well as the unintended...; 关键词：yeast artificial chromosome DNA storage EPIGENETICS chromatin accessibility histone H3K4 tri-methylation

Evidence of constraint in the 3D genome for trans-splicing in human cells: 《Science China(Life Sciences)》2020年第9期1380-1393,共14页Cong Liu Yiqun Zhang Xiaoli Li Yan Jia Feifei Li Jing Li Zhihua Zhang; supported by the National Natural Science Foundation of China(31671342,31871331,91540114,and 31401112)。; Fusion transcripts are commonly found in eukaryotes, and many aberrant fusions are associated with severe diseases, including cancer. One class of fusion transcripts is generated by joining separate transcripts throug...; 关键词：TRANS-SPLICING chromatin interaction 3D genome spatial clustering

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