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Analysis of the mechanism of aldo-keto reductase dependent cis-platin resistance in HepG2 cells based on transcriptomic and NADH metabolic state: 《BIOCELL》2023年第4期879-889,共11页TINGTING SUN XUE SUN XIN WANG RUI GUO YUANHUA YU LE GAO; supported by the Science and Technology Development Plan Project of Jilin Province,China[20200708101YY];The Foundation of Jilin Province Science and Technology Department[20200801062GH].; Background:Aldo-keto oxidoreductase(AKR)inhibitors could reverse the resistance of several cancer cells to cis-platin,but their role in resistance remains unclear.Methods:We verified the difference of AKR1Cs expressio...; 关键词：Aldo-keto oxidoreductase CIS-PLATIN HepG2 NAD(P)H-dependent oxidoreductases RNA sequencing

Potential impact of combined inhibition of 3a-oxidoreductases and 5a-reductases on prostate cancer被引量：2: 《Asian Journal of Urology》2019年第1期50-56,共7页Michael V.Fiandalo Daniel T.Gewirth James L.Mohler; This study was supported by the DoD Prostate Cancer Research Program Award(No.W81XWH-16-1-0635);the National Cancer Institute(NO.P01CA77739 and NO.R21CA205108)to James L.Mohler;Post-doctoral Training Award(No.W81XWH-15-1-0409)to Michael V.Fiandalo;DoD Synergistic Idea Development Award(No.W81XWH-14-1-0520)to Dan T.Gewirth;NCI Cancer Center Support Grant to Roswell Park Comprehensive Cancer Center for the Bioanalytics,Metabolomics and Pharmacokinetics,Pathology Network,and Genomics Shared Resources(No.P30CA016056).; Prostate cancer(PCa)growth and progression rely on the interaction between the androgen receptor(AR)and the testicular ligands,testosterone and dihydrotestosterone(DHT).Almost all men with advanced PCa receive androge...; 关键词：Androstanediol DIHYDROTESTOSTERONE DUTASTERIDE 3a-oxidoreductases Androgen deprivation therapy ABIRATERONE

Effect of Cuzhi liquid on learning and memory dysfunction in a mouse model of Alzheimer's disease: 《Journal of Traditional Chinese Medicine》2018年第6期890-895,共6页Liu Lijuan Yu Chen Liu Junbao; Supported by Henan Province Medicine Scientific Technological Project(No.200903133); OBJECTIVE: To examine the effects of Cuzhi liquid on learning and memory abilities in a mouse model of Alzheimer's disease(AD).METHODS: One hundred mice were divided into the normal, AD model, piracetam group, Cuzhi l...; 关键词：Alzheimer disease Learning Memory ACETYLCHOLINESTERASE OXIDOREDUCTASES NITRIC oxide MALONDIALDEHYDE Amyloidogenic proteins Lymphoma B-cell Cuzhi LIQUID

Protein engineering of oxidoreductases utilizing nicotinamide-based coenzymes,with applications in synthetic biology被引量：4: 《Synthetic and Systems Biotechnology》2017年第3期208-218,共11页Chun You Rui Huang Xinlei Wei Zhiguang Zhu Yi-Heng Percival Zhang; This study was mainly supported by the Key Research Program of the Chinese Academy of Sciences(Grant No.ZDRW-ZS-2016-3);1000-youth program of China to CY and the National Natural Science Foundation of China(Grant No.31600636);Funds were partially provided by the DOE EERE award(DE-EE0006968)to YPZ.; Two natural nicotinamide-based coenzymes(NAD and NADP)are indispensably required by the vast majority of oxidoreductases for catabolism and anabolism,respectively.Most NAD(P)-dependent oxidoreductases prefer one coenz...; 关键词：Coenzyme engineering Nicotinamide-based coenzymes NAD NADP Protein engineering Synthetic biology Biomimetic coenzymes

Synthesis of NAD analogs to develop bioorthogonal redox system被引量：7: 《Science China(Physics,Mechanics & Astronomy)》2013年第3期296-300,共5页; supported by the National Basic Research Program of China (2012CB721103);;the National Natural Science Foundation of China (21102143); Three new nicotinamide adenine dinucleotide(NAD) analogs were synthesized,and their characteristics as cofactors for Escherichia coli malic enzyme(ME) and its double mutant ME L310R/Q401C were analyzed.Each pair of th...; 关键词：NAD analog bioorthogonal OXIDOREDUCTASES chemical biology

Serological Diagnosis of Liver Metastasis in Patients with Breast Cancer被引量：6: 《Clinical oncology and cancer researeh》2012年第1期57-62,共6页Rui Cao Li-ping Wang; Objective To diagnose and explore the serological diagnostic factors for liver metastasis in patients with breast cancer before symptoms occur. Methods A total of 430 female in-patients with breast cancer of stages 0 ...; 关键词：breast neoplasms LIVER neoplasm metastasis OXIDOREDUCTASES GAMMA-GLUTAMYLTRANSFERASE

Structural and functional alterations of two multidomain oxidoreductases induced by guanidine hydrochloride被引量：1: 《Acta Biochimica et Biophysica Sinica》2010年第1期30-38,共9页Ming Jiao Yu-Ling Zhou Hong-Tao Li De-Ling Zhang Jie Chen Yi Liang; The unfolding and refolding of two multidomain oxido- reductases, bovine liver catalase and flavoprotein bovine milk xanthine oxidase （XO）, have been analyzed by fluor- escence spectroscopy, circular dichroism, and...; 关键词：CATALASE xanthine oxidase protein folding fluorescence spectroscopy enzymatic activity

Histochemical Localization of Glutathione Dependent NBT-Reductase in Mouse Skin: 《Biomedical and Environmental Sciences》2001年第3期237-240,共4页YOGESHWER SHUKLA 1Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Post Box 80, M. G. Marg, Lucknow-226 001, India; Objective Localization of the glutathione dependent Nitroblue tetrazolium (NBT) reductase in fresh frozen sections of mouse skin and possible dependence of NBT reductase on tissue thiol levels has been investigated. ...; 关键词：ANIMALS Cell Division FEMALE GLUTATHIONE Mice Nitroblue Tetrazolium OXIDOREDUCTASES Skin

Protective effect of Prostane in experimental prostatic hyperplasia in rats被引量：2: 《Asian Journal of Andrology》1999年第4期175-179,共5页S.K.Mitra R.Sundaram A.R.Mohan S.Gopumadhavan M.V.Venkataranganna Udupa Venkatesha S.J.Seshadri S.D.Autrulikar; Aim: Prostane, a polyherbal formulation, was evaluated for its efficacy on 5α-reductase inhibition, α-adrenergic anta-gonistic activity and testosterone-induced prostatic hyperplasia. Methods: 5α-reductase inhibiti...; 关键词：Prostane BPH OXIDOREDUCTASES adrenergic alpha-antagonists enzyme inhibitors PROSTATE HYPERPLASIA

Effects of electro-acupuncture on 5-HT,NOS and gastric mucosa in stress rats被引量：2: 《World Journal of Gastroenterology》1997年第3期51-51,共1页ZHU Shun Li, XU Guan Sun, WANG Zhen Jiu, CHEN Quan Zhu and JIAO Jie Institute of Acupuncture and Meridians, Anhui College of Traditional Chinese Medicine, Hefei 230038, Anhui Province, China; AIM To study the effects of electro acupuncture (EA) on 5 HT, NOS, NO and gastric mucosa in stress rats. METHODS By biochemical methods, the changes of 5 HT and NOS in gastric mucosa, NO and 5 HT in serum were ...; 关键词：electroacupuncture \ serotonin/acu MOXIBUSTION EFFECTS \ AMINOACID oxidoreductases/acu_moxibustion EFFECTS \ GASTRIC mucosa/acu_moxibustion EFFECTS

OXIDOREDUCTASES