The phenomena of pain,addiction,and anesthesia overlap through shared neurobiological mechanisms involving neurotransmitters and neural circuits.Central to these experiences is the principle of neuroplasticity,wherein...
This work was supported by the Key-Area Research and Development Program of Guangdong Province(2020B0303070002);the National Natural Science Foundation of China(31870077).
Resveratrol,a valuable plant-derived polyphenolic compound with various bioactivities,has been widely used in nutraceutical industries.Microbial production of resveratrol suffers from metabolic burden and low malonyl-...
Opioid analgesics remain the first choice for the treatment of moderate to severe pain, but they are also notorious for their respiratory depression and addictive effects. This study focused on the pharmacology of a n...
Venlafaxine, an SNRI (serotonin-norepinephrine reuptake inhibitor) drug, is commonly used to treat depression. Although it is very rare, venlafaxine may lead to addiction or abuse in some patients. To date, there ar...
Erratum to: SCIENCE CHINA Life Sciences, November 2015 Vol.58 No.11:1169-1170 doi: 10.1007/s11427-015-4921-5 The figure legend mistakenly referred to Reference 3 instead of Reference 1. It should read: "Adapted ...
Acknowledgements This work was supported by the National Key Technology R&D Program in the 12th Five-Year Plan of China (No 2012BAI01B07) and the National Natural Science Foundation of China (No Ul132602 and 81171257), and was sponsored by the K C WONG Magna Fund at Ningbo University.
Aim: Glutamatergic neurotransmission in the nucleus accumbens (NAc) is crucial for the relapse to heroin seeking. The aim of this study was to determine whether mGluR5 in the NAc core or shell involved in heroin se...
Aim: To investigate the different effects of heroin and milk in activating the corticostriatal system that plays a critical role in reward reinforcement learning. Methods: Male SD rats were trained daily for 15 d to...
Association between the reward caused by consuming drugs and the context in which they are consumed is essential in the formation of morphine-induced conditioned place preference (CPP). Glucocorticoid receptor (GRs) a...
Gene expression profiling of Drosophila melanogaster, an invertebrate model organism, applied to DNAmicroarray promises to provide novel insights into the important pathways and molecules that may contribute to the ri...
sponsored by a grant from the Sichuan Provincial Education Department(Influence of AGS3 on"reversible protein phosphorylation"in cortical neu-rons of morphine-addicted rats),No.2005B016
The prefrontal cortex is involved in the regulation and control of substance addiction-related cognitive, behavioral, and emotional changes. The present study identified prefrontal cortex protein profiles in morphine-...