10-HYDROXYCAMPTOTHECIN

作品数：22被引量：84H指数：5
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相关领域：医药卫生更多>>
相关作者：唐中华祖元刚于景华周建军刘键更多>>
相关机构：东北林业大学中国科学院上海生命科学研究院上海艾韦特医药科技有限公司上海医药工业研究院更多>>
相关期刊：《American Journal of Analytical Chemistry》《Acta Pharmacologica Sinica》《Science China Chemistry》《Chemical Research in Chinese Universities》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Fine-tuning the structure-tolerance-antitumor efficacy axis of prodrug nanoassemblies via branched aliphatic functionalization被引量：1
《Nano Research》2024年第4期2908-2918,共11页Guanting Li Fengli Xia Hongying Xiao Shunzhe Zheng Shuwen Fu Han Qiao Qianhui Jin Xuanbo Zhang Dun Zhou Chutong Tian Jin Sun Zhonggui He Bingjun Sun 
supported by National Natural Science Foundation of China(Nos.82272151,82204318 and 82173766);Doctoral Scientific Research Staring Foundation of Liaoning Province(No.2021-BS-130);General Program of Department of Education of Liaoning Province(No.LJKZ0953);Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program(No.RC220389).
Small-molecule prodrug nanoassemblies have emerged as efficient antitumor drug delivery systems.However,in the case of camptothecins-based prodrug nanoassemblies,linear aliphatic side chain modification often results ...
关键词：prodrug nanoassembly self-assembly antitumor efficacy TOLERANCE 7-ethyl-10-hydroxycamptothecin(SN_(3)8) 
Boosting SN38-based oral chemotherapy to combine reductionbioactivated structured lipid-mimetic prodrug with ascorbic acid被引量：1
《Nano Research》2022年第10期9092-9104,共13页Helin Wang Qi Lu Yifan Miao Jiaxuan Song Mingyang Zhang Zixuan Wang Haotian Zhang Zhonggui He Chutong Tian Jin Sun 
supported by the National Key Research and Development Program of China(No.2021YFA0909900);the National Natural Science Foundation of China(Nos.82073777,82104109,and 82173766).
The reduction-responsive disulfide bonds have been widely used as bioactive linkages to facilitate a rapid release of anticancer drugs into tumor cells.However,the activation can be hindered by the kinetics of the thi...
关键词：oral chemotherapy structured lipid-mimetic prodrug 7-ethyl-10-hydroxycamptothecin(SN38) ascorbic acid 
MicroRNA-181a is elevated by 10-hydroxycamptothecin and represses lung carcinoma progression by downregulating FOXP1
《BIOCELL》2022年第2期417-431,共15页LI PAN WENTING YI DONGMIN LIANG YULONG ZHAO RANRAN WANG PINGYU WANG YOUJIE LI JIAXUAN XIN YUNFEI YAN SHUYANG XIE 
supported by the National Natural Science Foundation of China(Nos.81702296,81772281);the Shandong Science and Technology Committee(Nos.2017GSF18124,ZR2019PC019,ZR2019MH022);the Health Commission of Shandong Province(Nos.2017WS737,2019KJK014);the Shandong Province Taishan Scholar Project(No.ts201712067).
Tumor progression is usually characterized by proliferation,migration,and angiogenesis,which is essential for supplying both nutrients and oxygen to the tumor cells.Therefore,targeting angiogenesis has been considered...
关键词：microRNA-181a 10-HYDROXYCAMPTOTHECIN ANGIOGENESIS Lung carcinoma 
Development of a method to quantify total and free irinotecan and 7-ethyl-10-hydroxycamptothecin(SN-38) for pharmacokinetic and bio-distribution studies after administration of irinotecan liposomal formulation被引量：4
《Asian Journal of Pharmaceutical Sciences》2019年第6期687-697,共11页Wenqian Yang Zimeng Yang Jieru Liu Dan Liu Yongjun Wang 
In 2015,liposomal formulation of irinotecan(ONIVYDE)has been approved by FDA and widely applied in the treatment of pancreatic cancer.ONIVYDE is a novel liposome formulation,entrapping CPT-11 in the aqueous core of ve...
关键词：IRINOTECAN Liposome UPLC-MS-MS SPE Pharmacokinetics Bio-distribution 
Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy被引量：16
《Acta Pharmaceutica Sinica B》2019年第4期843-857,共15页Caifang Gao Jianming Liang Ying Zhu Chengli Ling Zhekang Cheng Ruixiang Li Jing Qin Weigen Lu Jianxin Wang 
financial support from the National Natural Science Foundation of China(No.81573616,81690263 and81773911,China);the Development Project of Shanghai Peak Disciplines-Integrated Medicine(No.20150407,China)
Chemotherapy outcomes for the treatment of glioma remains unsatisfactory due to the inefficient drug transport across the blood–brain barrier(BBB) and insufficient drug accumulation in the tumor region. Although many...
关键词：GLIOMA CASEIN MENTHOL NANOPARTICLES BRAIN targeting Blood–brain barrier 10-HYDROXYCAMPTOTHECIN 
Multifunctional Cholesterol-modified Dendrimers for Targeted Drug Delivery to Cancer Cells Expressing Folate Receptors被引量：6
《Chinese Journal of Polymer Science》2019年第2期129-135,共7页Fan-Fan Fu Ben-Qing Zhou Zhi-Jun Ouyang Yi-Lun Wu Jing-Yi Zhu Ming-Wu Shen Jin-Dong Xia Xiang-Yang Shi 
financially supported by the Fundamental Research Funds for the Central Universities(for M.Shen and X.Shi);the National Natural Science Foundation of China(Nos.81761148028and 21773026);the Science and Technology Commission of Shanghai Municipality(Nos.15520711400 and 17540712000)
We present here the development of cholesterol(Chol)-modified dendrimer system for targeted chemotherapy of folate(FA)receptor-expressing cancer cells. In our study, poly(amidoamine)(PAMAM) dendrimers of generation 5(...
关键词：PAMAM DENDRIMERS Folate CHOLESTEROL 10-HYDROXYCAMPTOTHECIN Targeted cancer therapy 
Synthesis of Camptothecin-lO-O-glucoside Using an Engineered Oleandomycin Glucosyltransferase
《Chemical Research in Chinese Universities》2018年第3期423-427,共5页ZHU Xuelin YE Qinmei WEN Chao CHEN Liping LIANG Guangping ZENG Ting ZHANG Dongmei JIANG Renwang 
Supported by the National Natural Science Foundation of China（No. 81573315）, the Natural Science Foundation of Guangdong Province, China（No.2015A030313313）, the Guangzhou Industry University Collaborative Innovation Major Projects, China （No.201508030016） and the Natural Science Foundation of Hainan Province, China（No. 817307）.
Oleandomycin glycosyltransferase variant P67T/S132F/A242V（ASP） was used to convert 10-hydroxycamptothecin into camptothecin-10-O-glucoside, which was confirmed by spectral analysis. Compared to the previously report...
关键词：Camptothecin-10-O-glucoside 10-HYDROXYCAMPTOTHECIN Glycosylation GLUCOSYLTRANSFERASE Antineoplastic 
Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system被引量：4
《Asian Journal of Pharmaceutical Sciences》2017年第6期542-549,共8页Yang Liu Juan Li Zhi Li Xing Tang Zhenzhong Zhang 
supported by the Major National Scientific Research Projects (2015CB932103)
A pH-responsive conjugate based 10-hydroxycamptothecin-thiosemicarbazide-polyethene glycol 2000 (10-HCPT-hydro-PEG) nano-micelles were prepared in our previous study. In the present study, ultra-performance liquid chr...
关键词：PHARMACOKINETICS 10-HYDROXYCAMPTOTHECIN CONJUGATE NANO-MICELLE PH-RESPONSIVE 
Preparation,characterization and pharmacokinetics of 10-hydroxycamptothecin nanosuspension被引量：1
《Journal of Chinese Pharmaceutical Sciences》2017年第8期574-581,共8页张毅 詹颖 庞宁 刘瑜洁 程士轩 李骥 杜祎甜 齐宪荣 
NSFC(Grant No.81473156,81673365);Fangzheng Foundation for funding of the work
10-Hydroxycamptothecin （HCPT） is a broad-spectrum anticancer drug, while its low solubility and instability severely limit its application. In this study, HCPT nanosuspension （HCPT-NSP）, also known as nanocrystal,...
关键词：10-HYDROXYCAMPTOTHECIN NANOSUSPENSION Nanocrystal High-pressure homogenization PHARMACOKINETICS 
Effects of the Molecular Weight of PLGA on Degradation and Drug Release In vitro from an mPEG-PLGA Nanocarrier被引量：2
《Chemical Research in Chinese Universities》2016年第5期848-853,共6页LIU Rui WANG Yan MA Yudan WU Yi GUO Yi XU Li 
Supported by the National Natural Science Foundation of China（Nos.81271697, 81571791, 31571017）.
We successfully synthesized four kinds of copolymers with varying molecular weights of poly（lactide- co-glycolide）（PLGA） to yield methoxy-poly（ethylene glycol）-block-poly（lactide-co-glycolide）（mPEG-PLGA） nan...
关键词：Poly（lactide-co-glycolide） 10-HYDROXYCAMPTOTHECIN NANOCARRIER Drug delivery 
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