METABOLOMIC

作品数:175被引量:496H指数:12
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相关领域:医药卫生更多>>
相关作者:张哲毕惠嫦杨宇卓赵一懿傅欣彤更多>>
相关机构:中山大学北京大学第三医院北京市药品检验所华中农业大学更多>>
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相关基金:国家自然科学基金高等学校学科创新引智计划中国博士后科学基金上海市自然科学基金更多>>
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  • 学科=医药卫生—临床医学x
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Landscapes of gut microbiome and blood metabolomic signatures in relapsing remitting multiple sclerosis
《Science China(Life Sciences)》2025年第4期1042-1056,共15页Jinzhou Feng Shi Tang Xiaolin Yang Mengjie Zhang Zhizhong Li Shaoru Zhang Yongliang Han Yongmei Li Philippe P.Monnier Gang Yu Peng Zheng Cunjin Zhang Ke Xu Xinyue Qin 
supported by the National Science Foundation of China (81701191, 82301720);Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0973, CSTB2023NSCQMSX0183, CSTB2023NSCQ-BHX0214);China Postdoctoral Science Foundation (2022M722384, 2023MD734128);the Joint Project of Chongqing Health Commission and Science and Technology Bureau (2020FYYX104);Chongqing Postdoctoral Special Support Foundation (2023CQBSHTB2010);Chongqing Postdoctoral Science Foundation (CSTB2023NSCQ-BHX0214);the First Affiliated Hospital of Chongqing Medical University Postdoctoral Science Foundation (CYYY-BSHPYXM-202310);CQMU Program for Youth Innovation in Future Medicine (W0168)。
Although disturbances in the gut microbiome have been implicated in multiple sclerosis(MS), little is known about the changes and interactions between the gut microbiome and blood metabolome, and how these changes aff...
关键词:relapsing remitting multiple sclerosis gut microbiota 16S rRNA gene sequence untargeted metabolomics lipid metabolism biomarker 
Metabolomic profiling and prognostication in CoVID-19 acute respiratory distress syndrome
《Journal of Intensive Medicine》2025年第1期108-110,共3页David Furfaro Xiaoyu Che Wenhao Gou Matthew J.Cummings Nischay Mishra Daniel Brodie Thomas Briese Oliver Fiehn W.Ian Lipkin Max R.O'Donnell 
CHEST Foundation Grant in COVID-192020(DMF).
To the Editor,Coronavirus disease 2019(COVID-19)-related acute respiratory distress syndrome(ARDS)is biologically and clinically heterogeneous with a broad spectrum of organ dysfunction and illness severity.[1] In COV...
关键词:DISTRESS ACUTE Metab 
Chronic prostatitis/chronic pelvic pain syndrome induces metabolomic changes in expressed prostatic secretions and plasma
《Asian Journal of Andrology》2025年第1期101-112,共12页Fang-Xing Zhang Xi Chen De-Cao Niu Lang Cheng Cai-Sheng Huang Ming Liao Yu Xue Xiao-Lei Shi Zeng-Nan Mo 
supported by the National Natural Science Foundation of China(No.81770759 and No.82270806);Innovation Project of Guangxi Graduate Education(No.YCBZ2022094).
Chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)is a complex disease that is often accompanied by mental health disorders.However,the potential mechanisms underlying the heterogeneous clinical presentation of...
关键词:BIOMARKER chronic prostatitis/chronic pelvic pain syndrome DEPRESSION INFLAMMATION metabolomics 
Effects of aflatoxin B1 on subacute exposure of hybrid groupers(Epinephelus fuscoguttatus♀×Epinephelus lanceolatus♂):Growth,liver histology,and integrated liver transcriptome and metabolome analysis
《Animal Nutrition》2024年第4期192-214,共23页Hao Liu Shuqing Liang Weibin Huang Yuanzhi Yang Menglong Zhou Baiquan Lu Biao Li Wenshan Cai Hengyang Song Beiping Tan Xiaohui Dong 
supported financially by the Research and Demonstration of Precision Functional Compound Feed Technology of Major Cultured Fishes and Shrimps in South China,China(2021B0202050002);the Department of Education of Guangdong Province,China(2021ZDZX4005);the China Agriculture Research System of MOF and MARA,China(CARS-47).
With the increasing incorporation of plant-based ingredients into the grouper diet,the issue of aflatoxin B1 (AFB1) contamination in the diet has become a significant concern.In this study,the negative effects of AFB1...
关键词:Aflatoxin B1 Hybrid grouper Transcriptomic METABOLOMIC LIVER 
Metabolomic profiling of cerebrospinal fluid in neurosyphilis:identification of potential diagnostic biomarkers
《皮肤性病诊疗学杂志》2024年第12期801-809,共9页HE Yuanyuan WU Jiaxin CHEN Zhaoqi DENG Ziliang WANG Haiying KE Wujian 
Objective This study aims to analyze metabolites in the cerebrospinal fluid(CSF)of neurosyphilis patients to identify potential diagnostic markers.Methods Untargeted metabolomics by liquid chromatography-mass spectrom...
关键词:NEUROSYPHILIS metabolomic profiling cerebrospinal fluid diagnostic biomarkers 
Effect of exogenous free N^(ε)-(carboxymethyl)lysine on diabetes-associated cognitive dysfunction:neuroinflammation,and metabolic disorders
《Food Science and Human Wellness》2024年第5期2970-2981,共12页Huang Zhang Lan Mo Xi Chen Mei Li Maiquan Li Yang Xu Maomao Zeng Zhiyong He Qingwu Shen Jie Chen Wei Quan 
supported by the National Natural Science Foundation of China(32302258,32172317);Changsha Municipal Natural Science Foundation(kq2202223).
Diabetes-associated cognitive dysfunction has already been attracted considerable attention.Advanced glycation end products(AGEs)from daily diets are thought to be a vital contributor to the development of this diseas...
关键词:Diabetes Cognitive dysfunction N^(ε)-(carboxymethyl)lysine NEUROINFLAMMATION METABOLOMIC 
Integrated 16S rRNA sequencing and metabolomic analysis reveals the potential protective mechanism of Germacrone on diabetic nephropathy in mice
《Acta Biochimica et Biophysica Sinica》2024年第3期414-426,共13页Yunguang Wang Xinxin He Mengjiao Xue Huan Yu Qiang He Juan Jin 
This work was supported by the grants from the Zhejiang Provincial Traditional Chinese Medicine Science and Technology Project(No.2022ZB273);the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(No.LHDMY24H270002);the Zhejiang Provincial Medical and Health Technology Project(No.2023KY158);the Cultivation Program for Excellent Young Talents of Hangzhou First People’s Hospital(No.YQNYC202131);the Science and Technology Special Project of Hangzhou Biomedicine and Health Industry Development Support(No.2021WJCY253).
Diabetic nephropathy(DN)is a severe complication of diabetes and the leading cause of end-stage renal disease and death.Germacrone(Ger)possesses anti-inflammatory,antioxidant and anti-DN properties.However,it is uncle...
关键词:diabetic nephropathy GERMACRONE gut microbiota untargeted fecal metabolomics 16S rRNA sequencing 
Metabolomic profiling reveals decreased serum cysteine levels during gestational diabetes mellitus progression
《Journal of Molecular Cell Biology》2024年第3期35-45,共11页Mengyu Lai Jiaomeng Li Jiaying Yang Qingli Zhang Yujia Gong Yuhang Ma Fang Fang Na Li Yingxiang Zhai Tingting Shen Yongde Peng Jia Liu Yufan Wang 
supported by grants from the National Natural Science Foundation of China(81870610);Shanghai Science and Technology Commission Foundation(21Y11904800 and 23ZR1451500);the Clinical Research Plan of SHDC(SHDC2020CR3065B);the National Key Research and Development Program of China(2021YFC2501600 and 2021YFC2501601).
Gestational diabetes mellitus(GDM)is a pregnancy-related metabolic disorder associated with short-term and long-term adverse health outcomes,but its pathogenesis has not been clearly elucidated.Investigations of the d...
关键词:gestational diabetes mellitus metabolomics CYSTEINE 
Washed microbiota transplantation for Crohn’s disease:A metagenomic,metatranscriptomic,and metabolomic-based study
《World Journal of Gastroenterology》2024年第11期1572-1587,共16页Shi-Ju Chen Da-Ya Zhang Xia Wu Fa-Ming Zhang Bo-Ta Cui Yi-Hao Huang Zu-Lun Zhang Rui Wang Fei-Hu Bai 
Supported by the Innovation Platform for Academicians of Hainan Province,No.YSPTZX202313;Hainan Province Clinical Medical Center,No.2021818;Hainan Provincial Health Industry Research Project,No.22A200078;Hainan Provincial Postgraduate Innovation Research Project,No.Qhyb2022-133;Hainan Medical University Graduate Student Innovative Research Project,No.HYYB2022A18;Nanjing Medical University Fan Daiming Research Funds for Holistic Integrative Medicine,No.2020-3HIM.
BACKGROUND Fecal microbiota transplantation(FMT)is a promising therapeutic approach for treating Crohn’s disease(CD).The new method of FMT,based on the automatic washing process,was named as washed microbiota transpl...
关键词:Crohn’s disease Clinical trials Fecal microbiota transplant METAGENOME Metatranscriptome METABOLOME 
Metabolomic Analysis in Saliva and Different Brain Regions of Older Mice with Postoperative Delirium Behaviors
《Biomedical and Environmental Sciences》2024年第2期133-145,共13页LIU Xiao CAO Ying LIN Xiao Wan GAO Dan Yang MIAO Hui Hui LI Tian Zuo 
funded by the Natural Science Foundation of Beijing(7212023);the National Natural Science Foundation of China(82071180)to HHM;the National Natural Science Foundation of China(82271206)to TZL。
Objective Postoperative delirium(POD)has become a critical challenge with severe consequences and increased incidences as the global population ages.However,the underlying mechanism is yet unknown.Our study aimed to e...
关键词:METABOLOMIC Postoperative delirium(POD) Mechanism Biological marker 
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