云南高校图书馆联盟文献共享服务平台- Γ-SECRETASE

Γ-SECRETASE: 作品数：23被引量：59H指数：5; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：殷莹曹鹏缪凤琴于春泳梁国标更多>>; 相关机构：东南大学清华大学第二军医大学台湾大学更多>>; 相关期刊：《National Science Review》《Advances in Bioscience and Biotechnology》《Acta Biochimica et Biophysica Sinica》《Medicinal Plant》更多>>; 相关基金：国家自然科学基金World Health Organization更多>>

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease: 《Neural Regeneration Research》2025年第1期174-180,共7页Yinglong Miao Michael S.Wolfe; supported in part by Award 2121063 from National Science Foundation(to YM);AG66986 from the National Institutes of Health(to MSW).; γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the ...; 关键词：Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics NOTCH

CNTNAP2 intracellular domain(CICD)generated byγ-secretase cleavage improves autism-related behaviors被引量：2: 《Signal Transduction and Targeted Therapy》2023年第7期3415-3426,共12页Jing Zhang Fang Cai Renbin Lu Xiaoliang Xing Lu Xu Kunyang Wu Zishan Gong Qing Zhang Yun Zhang Mengen Xing Weihong Song Jia-Da Li; This work was supported by funding from National Natural Science Foundation of China(NSFC),Grant/Award Number:81770780 and 31972913;Key Research and Development Programs from Hunan Province,Grant/Award Number:2021DK2001;Guangdong Key Project in‘Development of New Tools for Diagnosis and Treatment of Autism’,Grant/Award Number:2018B030335001;Strategic Priority Research Program of Central South University,Grant/Award Number:ZLXD2017004;The project has been funded in part with Independent Exploration and Innovation Project of Central South University,Grant/Award Number:2018zzts393.; As the most prevalent neurodevelopmental disorders in children,autism spectrum disorders(ASD)are characterized by deficits in language development,social interaction,and repetitive behaviors or inflexible interests.Co...; 关键词：BEHAVIORS CLEAVAGE RESIDUES

Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease: 《Neural Regeneration Research》2022年第1期31-37,共7页Mercedes A.Hernández-Sapiéns Edwin E.Reza-Zaldívar Ana L.Márquez-Aguirre Ulises Gómez-Pinedo Jorge Matias-Guiu Ricardo R.Cevallos Juan C.Mateos-Díaz Víctor J.Sánchez-González Alejandro A.Canales-Aguirre; supported by the Consejo Nacional de Ciencia y Tecnología Scholarship 711893(to MAH)and 711874(to EER)。; The presenilin genes(PSEN1 and PSEN2)are mainly responsible for causing early-onset familial Alzheimer’s disease,harboring~300 causative mutations,and representing~90%of all mutations associated with a very aggressiv...; 关键词：familial Alzheimer’s disease familial Alzheimer’s disease-induced pluripotent stem cells models induced pluripotent stem cells neurogenesis neuronal differentiation Notch presenilin 1 PSEN1 mutations γ-secretase complex

Critical thinking on amyloid-beta-targeted therapy:challenges and perspectives被引量：8: 《Science China(Life Sciences)》2021年第6期926-937,共12页Bin-Lu Sun Yang Chen Dong-Yu Fan Chi Zhu Fan Zeng Yan-Jiang Wang; supported by the National Natural Science Foundation of China(91749206,81930028,81625007,81870860,31921003)。; Amyloid-beta(Aβ)plays a pivotal role in the pathogenesis of Alzheimer's disease(AD)and has been regarded as the main therapeutic target for AD.However,most of the Aβ-targeted clinical trials have not succeeded.There...; 关键词：Alzheimer's disease amyloidβ immunotherapy Β-SECRETASE Γ-SECRETASE enzyme inhibitor multi-target therapy tertiary prevention strategy

Physalin B reduce secretion of Aβ by inhibiting phosphorylation of STAT3 via down-regulated expression of β-secretase and γ-secretase: 《中国药理学与毒理学杂志》2019年第6期426-427,共2页BAI Shan-shan ZHUO Lin SUN Yi SHI Ru-ling XIE Yong-sheng ZHANG Wei; National Natural Science Foundation(U1604108);Key Science and Technology Program of Henan Province(152102310112; 162102310121);National Training Program of Innovation for Undergraduates(201710472009); OBJECTIVE Extracellular amyloid-β(Aβ) plaques are one of the major pathological hallmarks of Alzheimer disease(AD). Therefore, decreasing Aβ levels is one strategyfor preventing the etiology of AD. Aβ peptides are...; 关键词：Alzheimer disease PHYSALIN B Β-AMYLOID protein BACE1 PS1 STAT3

Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models被引量：1: 《Translational Neurodegeneration》2019年第1期433-449,共17页Inger Lauritzen Anaïs Bécot Alexandre Bourgeois Raphaëlle Pardossi-Piquard Maria-Grazia Biferi Martine Barkats Fréderic Checler; This work has been developed and supported through the LABEX(excellence laboratory,program investment for the future)DISTALZ(Development of lnnovative Strategies for a Transdisciplinary approach to ALZheimers disease)and by Fondation Alzheimer.A.Be and A.Bo were granted from DISTALZ.; Background:We recently demonstrated an endolysosomal accumulation of theβ-secretase-derived APP C-terminal fragment(CTF)C99 in brains of Alzheimer disease(AD)mouse models.Moreover,we showed that the treatment with th...; 关键词：Extracellular vesicles C99 APP-CTFs Homo-and hetero-oligomerization ENDOSOMES LYSOSOMES trans-Golgi network SorLA γ-Secretase inhibition Presenilin knockout Alzheimer’s disease

Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular carcinoma cells被引量：9: 《World Journal of Gastroenterology》2015年第33期9727-9735,共9页Bing Han Shi-Hai Liu Wei-Dong Guo Bin Zhang Jian-Ping Wang Yu-Kun Cao Jun Liu; Supported by Shandong Provincial Natural Science Foundation,China,No.ZR2012HQ039 and No.ZR2014HP065;National Natural Science Foundation of China,No.81373172 and No.81402579; AIM: To confirm the anti-invasion and anti-migration effects of down-regulation of Notch1 combined with interleukin(IL)-24 in hepatocellular carcinoma(HCC) cells.METHODS: γ-secretase inhibitors(GSIs) were used to dow...; 关键词：NOTCH signaling pathway INTERLEUKIN-24 Γ-SECRETASE

Amyloid precursor-like protein 2 C-terminal fragments upregulate S100A9 gene and protein expression in BV2 cells: 《Neural Regeneration Research》2014年第21期1923-1928,共6页Guangzhe Li Hui Chen Lin Cheng Rongjie Zhao Junchang Zhao Yanji Xu; supported by the Natural Science Foundation of Technology Gallery in Jilin Province of China,No.2011-15237;the National Natural Science Foundation of China,No.81160159; The murine microglial cell line BV2 has neuroprotective effects, but is toxic to neurons by secret-ing inlfammatory cytokines, and is an important target in the treatment of nerve inlfammation and neurodegenerative di...; 关键词：nerve regeneration NEURODEGENERATION Alzheimer’s disease APLP2 S100A9 C-terminal fragments amyloid precursor protein BV2 cells Γ-SECRETASE NSFC grant neural regeneration

Sex effect on presenilins expression in post-natal rat brain: 《Advances in Bioscience and Biotechnology》2013年第12期1086-1094,共9页Paola Piscopo Sonia Canterini Valentina Carletti Paolo Rosa Alessio Crestini Maria Teresa Fiorenza Annamaria Confaloni; Presenilin 1 and presenilin 2 are widely expressed during brain development. Several mutations in these proteins have been associated with autosomal-dominant inherited forms of Alzheimer disease. Their expression is r...; 关键词：Development SEX PRESENILINS Γ-SECRETASE Rats Sexual DIMORPHISM

γ-secretase抑制剂MRK-560对原代培养脑胶质瘤细胞抗肿瘤效果的研究: 《广州医学院学报》2012年第6期18-21,共4页曹鹏梁勇范涤韩松于春泳冯思哲梁国标; 目的:探讨Notch通路特异性阻断药物MRK-560在体外抑制原代培养脑胶质瘤细胞增殖及诱导肿瘤细胞凋亡的能力。方法:选取24例脑胶质瘤标本进行原代分离以获取脑胶质瘤细胞,分别给予不同浓度的MRK-560共培养48 h,检测肿瘤细胞胞内γ-secret...; 关键词：脑胶质瘤 NOTCH通路 MRK-560

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