ANTI-METASTASIS

作品数：16被引量：63H指数：4
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First total synthesis,antitumor evaluation and target identification of mornaphthoate E:A new tubulin inhibitor template acting on PI3K/Akt signaling pathway
《Acta Pharmaceutica Sinica B》2024年第5期2177-2193,共17页Peipei Shan Tao Ye Ying-De Tang Hui Song Chao Wang Kongkai Zhu Feifei Yang Shi-Lei Zhang Pei-Wen Su Shuanhu Gao Hua Zhang 
This project was financially supported by the National Natural Science Foundation of China(No.82073729,22225105).
Mornaphthoate E(MPE)is a prenylated naphthoic acid methyl ester isolated from the roots of a famous Chinese medicinal plant Morinda officinalis and shows remarkable cytotoxicity against several human tumor cell lines....
关键词：Mornaphthoate E Tubulin inhibitor ANTITUMOR ANTI-METASTASIS Breast cancer PI3K/AKT 
Combination losartan with hyaluronic acid modified diethyldithiocarbamate loaded hollow copper sulfide nanoparticles for the treatment of breast cancer and metastasis
《Chinese Chemical Letters》2024年第3期406-414,共9页Haili Hu Weiwei Zhang Lei Lei Fan Tong Huilin Zhang Yiwei Zhang Wenqin Yang Yilu Tang Ruyi Lin Xue Xia Jiamei Li Shiyong Song Huile Gao 
supported by National Natural Science Foundation of China(No.82173762);Research Funds of Sichuan Science and Technology Department(Nos.2022JDJQ0050,2022YFS0334);111 Project(No.B18035)。
The application of photothermal therapy(PTT)is greatly limited by the low accumulation of photothermal agents,uneven photothermal distribution,and heat endurance of cancer cells.Worse still,despite PTT enhances immuno...
关键词：Targeted drug delivery system Hollow copper sulfide nanoparticles Photothermal therapy Hyaluronic acid Breast cancer ANTI-METASTASIS 
SY-707,an ALK/FAK/IGF1R inhibitor,suppresses growth and metastasis of breast cancer cells被引量：1
《Acta Biochimica et Biophysica Sinica》2022年第2期252-260,共9页Ping Liu Yinghui Sun Shuang Liu Jing Niu Xijie Liu Qiaoyun Chu 
supported by the grants from the National Major Scientific and Technological Special Project for“Significant New Drugs Development”during the Twelfth Five-year Plan Periods(Nos.2012ZX09401007 and 2015ZX09101001).
Focal adhesion kinase(FAK),a multi-functional cytoplasmic tyrosine kinase,plays a critical role in cancer migration,proliferation and metastasis via regulating multiple signaling pathways.SY-707 is an anaplastic lymph...
关键词：SY-707 ANTI-TUMOR ANTI-METASTASIS breast cancer 
Cancer-specific calcium nanoregulator suppressing the generation and circulation of circulating tumor cell clusters for enhanced anti-metastasis combinational chemotherapy被引量：2
《Acta Pharmaceutica Sinica B》2021年第10期3262-3271,共10页Dan Li Yingli Wang Chang Li Qiu Wang Bingjun Sun Haotian Zhang Zhonggui He Jin Sun 
supported by National Natural Science Foundation of China(No.81773656);Liaoning Revitalization Talents Program(No.XLYC1808017,China);Shenyang Youth Science and Technology Innovation Talents Program(No.RC190454,China)。
Tumor metastasis is responsible for chemotherapeutic failure and cancer-related death.Moreover,circulating tumor cell(CTC)clusters play a pivotal role in tumor metastasis.Herein,we develop cancer-specific calcium nano...
关键词：Cell-cell junctions DIGOXIN DOXORUBICIN Homologous targeting Circulating tumor cell clusters Epithelial-mesenchymal transition Breast cancer Lung metastasis 
Self-propelled nanomotor reconstructs tumor microenvironment through synergistic hypoxia alleviation and glycolysis inhibition for promoted anti-metastasis被引量：4
《Acta Pharmaceutica Sinica B》2021年第9期2924-2936,共13页Wenqi Yu Ruyi Lin Xueqin He Xiaotong Yang Huilin Zhang Chuan Hu Rui Liu Yuan Huang Yi Qin Huile Gao 
supported by National Natural Science Foundation of China(No.81961138009);the Fundamental Research Funds for the Central Universities(Nos.SCU2017A001,2018SCUH0024,China);111 Project(No.B18035,China);the Key Research and Development Program of Science and Technology Department of Sichuan Province(No.2020YFS0570,China)
Solid tumors always exhibit local hypoxia,resulting in the high metastasis and inertness to chemotherapy.Reconstruction of hypoxic tumor microenvironment(TME)is considered a potential therapy compared to directly kill...
关键词：NANOMOTOR Microenvironment modulation HYPOXIA Aerobic glycolysis Triple negative breast cancer ANTI-METASTASIS Enzyme-powered Chemotherapy 
VEGFR2-targeted antibody fused with IFNamut regulates the tumor microenvironment of colorectal cancer and exhibits potent anti-tumor and anti-metastasis activity被引量：5
《Acta Pharmaceutica Sinica B》2021年第2期420-433,共14页Pengzhao Shang Rui Gao Yijia Zhu Xiaorui Zhang Yang Wang Minji Guo Hui Peng Min Wang Juan Zhang 
supported by grants from“Double First-Class”University Project(CPU2018PZQ12 and CPU2018GY14,China);National Natural Science Foundation of China(Grant 81993223);National Natural Science Foundation of China(Grant 81773755);Natural Science Foundation of Jiangsu Province(BK20161459,China);Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX19_0162,China);the National Students’Platform for Innovation and Entrepreneurship Training Program(201810316010Y,China)
Although interferonα(IFNα)and anti-angiogenesis antibodies have shown appropriate clinical benefit in the treatment of malignant cancer,they are deficient in clinical applications.Previously,we described an anti-vas...
关键词：Anti-VEGFR2 IFNamut Tumor microenvironment Colorectal cancer Liver metastasis Cancer immunotherapy 
Anticancer effects of Chinese herbal medicines on esophageal carcinoma: a literature research-based review
《TMR Cancer》2020年第5期211-220,共10页Shi-Yuan Jiang Min-Yan Li Ruo-Fei Du Wen-Bin Wang Wei-Ping Gao 
Background:Esophageal carcinoma is one of the most common malignant tumors worldwide,with China the hardest hit area accounts for nearly 50 percent of the morbidity and mortality each year.Despite the deepening of the...
关键词：Esophageal carcinoma Chinese herbal medicine Inhibition of proliferation ANTI-METASTASIS 
Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects被引量：2
《Acta Pharmaceutica Sinica B》2020年第6期1106-1121,共16页Yan Chen Chen Chen Xiaojuan Zhang Chuanchuan He Pengxuan Zhao Minsi Li Ting Fan Ruicong Yan Yao Lu Robert J.Lee Muhammad Waseem Khan Muhammad Sarfraz Xiang Ma Tan Yang Guangya Xiang 
supported by the Programs of the National Natural Science Foundation of China(Grant Nos.81673368,81603046,81703446 and 81973257)
Platinum-based chemotherapy is used for non-small cell lung cancer(NSCLC).However,it has side effects and minimum efficacy against lung cancer metastasis.In this study,platinum-curcumin complexes were loaded into pH a...
关键词：PLATINUM CURCUMIN Complex Nanoparticles Non-small cell lung cancer ANTI-METASTASIS Drug delivery 
Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer被引量：8
《Acta Pharmaceutica Sinica B》2019年第4期819-831,共13页Jiaojie Wei Yang Long Rong Guo Xinlei Liu Xian Tang Jingdong Rao Sheng Yin Zhirong Zhang Man Li Qin He 
funded by the Major Projects of the National Natural Science Foundation of China(81690261);the National Natural Science Foundation of China(81703450);the Postdoctoral Research Foundation of China(2017M620429)
Immunotherapy has become a highly promising paradigm for cancer treatment. Herein, a chemo-immunotherapy was developed by encapsulating chemotherapeutic drug doxorubicin(DOX) and Toll-like receptor 7 agonist imiquimod...
关键词：CHECKPOINT BLOCKADE Immunotherapy IMMUNOGENIC cell death ANTI-METASTASIS Nanoparticle 
The 150 most important questionsin cancer research and clinical oncology series:questions 40-49被引量：2
《Chinese Journal of Cancer》2017年第7期285-288,共4页Chinese Journal of Cancer 
Since the beginning of 2017,Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology,which sparkle diverse thoughts,interesting communications,and potential coll...
关键词：Mouse models Cervical CANCER ANTI-METASTASIS drug CACHEXIA Oligo-metastasis WARBURG effect Epstein–Barr virus Lung CANCER 
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