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IL-2-loaded Polypeptide Nanoparticles for Enhanced Anti-cancer Immunotherapy被引量：2: 《Chinese Journal of Polymer Science》2023年第7期1059-1068,共10页Xiao-Shuang Wang Zhao-Shi Zheng Meng-Fei Zheng Di Wang Hong-Lei Zhang Zhen-Qian Zhang Zhi-Lin Liu Zhao-Hui Tang Xue-Mei Han; supported by the National Natural Science Foundation of China(Nos.52025035,51873206 and 52203198);the Project of Health research talents Project of Jilin Province(No.2020SCZ06);the Project of Jilin Province Development and Reform Commission(No.2021C043-6);the Jilin Provincial International Cooperation Key Laboratory of Biomedical Polymers(No.20210504001GH).; Interleukin 2 (IL-2) is widely used as an active immunotherapeutic agent in clinical metastatic cancers. However, its therapeutic concentrations do not last long due to its short half-life. Thus, only a transient prol...; 关键词：POLYPEPTIDE Phenylboronic acid Boron-nitrogen coordination Interleukin 2 ROS-responsive

Homopolypeptide Vesicles Triggered by Side-Chain Hydration被引量：1: 《Chinese Journal of Polymer Science》2022年第12期1631-1639,I0009,共10页Xin-Jie Shi Zhen Liu Yang-Chun Xie Min Xu Xiao-Hua He; financially supported by the National Natural Science Foundation of China (No.51773063);the Open Project of Shanghai Key Laboratory of Magnetic Resonance。; The formation of homopolypeptide vesicles and the identification of their self-assembly mechanism have been challenging issues in the field of polymer self-assembly. Using complementary circular dichroism(CD), Fourier...; 关键词：POLYPEPTIDE VESICLE Self-assembly HYDROPHOBIC MICELLE

Clickable,Oxidation-Responsive and Enzyme-Degradable Polypeptide:Synthesis,Characterization and Side Chain Modification: 《Chinese Journal of Polymer Science》2022年第11期1360-1368,共9页Yan-Zhi Lu An-Qi Gu Tian-Lun Shen Ji-Hong Sun Jun Ling; financially supported by the Key Research and Development Program of Zhejiang Province(No.2019C03014);the National Natural Science Foundation of China(No.21871232)。; Modifications at polypeptide side chains have been found to affect conformational and properties,which is a vital strategy to prepare functional polypeptides.This contribution describes the synthesis of homo and co-po...; 关键词：POLYPEPTIDES Ring-opening polymerization Stimuli-responsive polymers N-carboxy anhydrides N-phenoxycarbonylα-amino acids

Helical Nonfouling Polypeptides for Biomedical Applications被引量：2: 《Chinese Journal of Polymer Science》2022年第5期433-446,共14页Chong Zhang Hua Lu; financially supported by the National Key Research and Development Program of China (No. 2019YFA0904203);the National Natural Science Fund for Distinguished Young Scholars (No. 22125101); Synthetic polypeptides,also known as poly(α-amino acid)s(PαAAs),are biomimetic and biodegradable polymers holding great potential for a variety of biomedical applications.Possessing the same peptide bonds as natural...; 关键词：Poly(α-amino acid) POLYPEPTIDE HELIX Nonfouling PEPylation

Biodegradable Polypeptide-based Vesicles with Intrinsic Blue Fluorescence for Antibacterial Visualization被引量：3: 《Chinese Journal of Polymer Science》2021年第11期1412-1420,共9页Yu-Ying Yang Ling-Shan Chen Min Sun Cong-Yu Wang Zhen Fan Jian-Zhong Du; financially supported by the National Natural Science Foundation of China(Nos.51803152,22075212 and 21925505);the program for professor of special appointment(Eastern Scholar)at Shanghai institutions of higher learning;Natural Science Foundation of Shanghai(No.19ZR1478800);National Science Fund for Distinguished Young Scholars。; Fluorescence imaging has been an indispensable tool to provide dynamic information about the localization and quantity of organisms.Meanwhile,due to the intrinsic hollow structure and modularized biofunctionalities,po...; 关键词：Polypeptide-based vesicles Intrinsic fluorescence Antibacterial visualization

Facile Synthesis of High Molecular Weight Polypeptides via Fast and Moisture Insensitive Polymerization of a-Amino Acid N-Carboxyanhydrides被引量：5: 《Chinese Journal of Polymer Science》2020年第10期1131-1140,I0007,共11页Yue Ming Wu Wei-Wei Zhang Rui-Yi Zhou Qi Chen Chen-Yu Xie Heng-Xue Xiang Bin Sun Mei-Fang Zhu Run-Hui Liu; This work was financially supported by the National Natural Science Foundation of China(Nos.21774031 and 21861162010);the National Key Research and Development Program of China(No.2016YFC1100401);Research Program of State Key Laboratory of Bioreactor Enginering,State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua University,the Fundamental Research Funds for the Central Universities(Nos.22221818014 and 50321041917001);The authors also thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.; Polypeptides have been widely utilized in the fields of biomaterials and biomedicine.Ever since N-carboxyanhydride(NCA)was reported by Hermann Leuchs in 1906,ring-opening polymerization of NCAS has been extensively us...; 关键词：NCA polymerization POLYPEPTIDE Open vessel Fast polymerization High Mw

Biofilm Disruption Utilizing α/β Chimeric Polypeptide Molecular Brushes被引量：6: 《Chinese Journal of Polymer Science》2019年第11期1105-1112,共8页Si Zhang Xi-Mian Xiao Fan Qi Peng-Cheng Ma Wei-Wei Zhang Cheng-Zhi Dai Dan-Feng Zhang Run-Hui Liu; financially supported by the National Natural Science Foundation of China (Nos. 21574038, 21774031, and 21861162010);the Natural Science Foundation of Shanghai (No. 18ZR1410300);the “Eastern Scholar Professorship” from Shanghai local government (No. TP2014034);the national special fund for State Key Laboratory of Bioreactor Engineering (No. 2060204);the Fundamental Research Funds for the Central Universities (No. 22221818014); Gram-negative bacteria can cause serious infections and are well known problems in biomedical practices. Biofilms of gramnegative bacteria are notorious for their frequently encountered resistance toward antibiotics. ...; 关键词：Molecular BRUSH CHIMERIC POLYPEPTIDE BIOFILM ANTIMICROBIAL resistance Host defense peptide

Dual Thermal-and p H-responsive Polypeptide-based Hydrogels被引量：6: 《Chinese Journal of Polymer Science》2017年第10期1243-1252,共10页fan-dong meng yun-xia ni si-fan ji xiao-hui fu yu-han wei 孙静李志波; financially supported by the National Natural Science Foundation of China(Nos.21434008 and 51225306);Natural Science Foundation of Shandong Province(No.ZR2015EM015);Taishan Scholars Program; Smart hydrogels have received increasing attention for their great potential for the applications in many fields. Herein, we report a facile approach to prepare a class of dual-responsive hydrogels assembled from synt...; 关键词：links chains bonds hierarchical ferric tensile hydrogel healing polymerization fabricate

Thermal and Redox Dual Responsive Poly(L-glutamate)with Oligo(ethylene glycol)Side-chains被引量：1: 《Chinese Journal of Polymer Science》2016年第12期1436-1447,共12页Xiao-hui Fu Yi-nan Ma 孙静李志波; financially supported by the National Natural Science Foundation of China(Nos.20974112 and 50821062); A series of poly（L-glutamate）s grafted with oligo（ethylene glycol）（OEG） side-chains through the thioether linkages （PALGn-g-EGx, x = 2, 3 and 4） were prepared by ring-opening polymerization （ROP） of γ-ally...; 关键词：N-carboxyanhydride （NCA） POLYPEPTIDE Ring-opening polymerization Click chemistry Stimuli-responsive.

Polypeptide Brushes Grown via Surface-initiated Ring-opening Polymerization of α-Amino Acid N-Carboxyanhydrides被引量：2: 《Chinese Journal of Polymer Science》2015年第7期931-931,932-946,共16页Yong Shen 李志波 Harm-Anton Klok; financially supported by the Sino-Swiss Science and Technology Cooperation(No.EG41-092011)as well as the Chinese Academy of Sciences(Visiting Professorship for Senior International Scientists to H.A.K.); Polypeptide brushes are attractive platforms to generate functional and responsive interfaces that are of potential interest due to their possible biodegradability, biocompatibility and tunable secondary structures. S...; 关键词：Polypeptide brushes Surface α-Amino acid N-carboxyanhydrides Ring-opening polymerization Secondary structure

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