6-MERCAPTOPURINE

作品数：21被引量：41H指数：4
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相关领域：医药卫生更多>>
相关作者：李晶晶薛鹏程祖磊更多>>
相关机构：蚌埠市第三人民医院更多>>
相关期刊：《Genomics, Proteomics & Bioinformatics》《Chinese Journal of Structural Chemistry》《Open Journal of Gastroenterology》《Asian Journal of Andrology》更多>>
相关基金：国家自然科学基金中国博士后科学基金更多>>
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N,S,Br co-doped carbon dots:One-step synthesis and fluorescent detection of 6-mercaptopurine in tablet
《Journal of Pharmaceutical Analysis》2024年第2期291-293,共3页Qi Wang Ying Cheng Lifeng Ding Shengling Li Jie Zhang Yulan Niu Ziye Jing 
support of Taiyuan Institute of Technology Scientific Research Initial Funding,China(Grant No.:2022KJ058);the Basic Research Project of Shanxi Province,China(Project No.:202203021212331);the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi,China(Program Nos.:2022L529 and 2022L532);the Fund for Shanxi“1331”Project,China.
6-mercaptopurine(6-MP),a purine derivative(3,7-dihydropurine-6-thione),has been utilized as an effective immunosuppressive drug for clinically treating leukemia and other autoimmune diseases[1].6-MP and its correspond...
关键词：PURINE SYNTHESIS eliminate 
A drug/carrier dual redox-responsive system based on 6-mercaptopurine dimer-loaded cysteine polymer nanoparticles for enhanced lymphoma therapy
《Nano Research》2022年第5期4544-4551,共8页Liying Wang Chunlei Dai Yifen Fang Xinru You Jun Wu 
This work was supported by the National Natural Science Foundation of China(Nos.51973243 and 52173150);International Cooperation and Exchange of the National Natural Science Foundation of China(No.51820105004);China Postdoctoral Science Foundation(No.2020M683058),the Science and Technology Planning Project of Shenzhen(No.JCYJ20190807155801657);Guangdong Innovative and Entrepreneurial Research Team Program(No.2016ZT06S029).
Many anticancer drugs have limited clinical applications owing to their unsatisfactory therapeutic efficacy or side effects.This situation can be improved by drug delivery systems or drug modification strategies.Herei...
关键词：6-mercaptopurine(6-MP) DIMER redox-responsive nanoparticle(NPs) cancer therapy 
Immunomodulators:still having a role?被引量：2
《Gastroenterology Report》2022年第1期178-187,共10页Jeffery M.Venner Charles N.Bernstein 
Immunomodulators,particularly the thiopurines and to a lesser extent methotrexate,were standard of care for inflammatory bowel diseases,including Crohn’s disease and ulcerative colitis,for>40 years.While there has be...
关键词：IMMUNOMODULATORS 6-mercaptopurine(6-MP) AZATHIOPRINE Crohn’s disease METHOTREXATE 
Ratiometric Fluorescence Detection of 6-Mercaptopurine Based on the Nanohybrid of Fluorescence Carbon Dots and Gold Nanoclusters被引量：1
《Journal of Sensor Technology》2021年第3期39-53,共15页Yanan Zhai Meixian Huang Lingfeng Jiang Hailin Liao 
The development of a simple and accurate quantitative method for the determination of 6-mercaptopurine (6-MP) is of great importance because of its serious side effects. Ratiometric fluorescence (RF) sensors are not s...
关键词：Gold Nanoclusters Carbon Dots 6-MERCAPTOPURINE Ratiometric Fluorescent Sensor 
TR3受体激动剂6-mercaptopurine对糖尿病ApoE-/-小鼠NF-κB p65/CylinD1通路影响及其与抗动脉硬化关系被引量：2
《蚌埠医学院学报》2019年第9期1137-1142,共6页李晶晶 祖磊 薛鹏程 
中央引导地方科技发展专项(2016080802D113)
目的:观察TR3受体激动剂(6-mercaptopurine,6-MP)对链脲佐菌素(streptozotocin,STZ)诱导的载脂蛋白E(apolipoprotein E,ApoE-/-)敲除糖尿病小鼠糖脂代谢及NF-κBp65/CylinD1通路的影响及其与抗动脉硬化的关系,探讨TR3受体在改善糖尿病...
关键词：糖尿病 APOE-/-小鼠 6-MP 动脉粥样硬化 血脂 TR3 NF-κBp65/CylinD1 
Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review被引量：15
《World Journal of Gastroenterology》2019年第9期1142-1157,共16页Adérson Omar Mourao Cintra Damiao Matheus Freitas Cardoso de Azevedo Alexandre de Sousa Carlos Marcela Yumi Wada Taciana Valéria Marcolino Silva Flávio de Castro Feitosa 
funded by Takeda Pharmaceuticals,Brazil
BACKGROUND Despite the advent of biological drugs, conventional therapy continues to be used in moderate to severe inflammatory bowel disease(MS-IBD). This study hypothesized that as a standard of treatment and the pr...
关键词：Inflammatory bowel diseases Steroids SULFASALAZINE MESALAMINE AZATHIOPRINE Methotrexate Mycophenolic acid CYCLOSPORINE TACROLIMUS 6-MERCAPTOPURINE 
Theoretical Investigation of Structures,Bonding and Electronic Properties for the Complexes of 6-Mercaptopurine and Ag8 Clusters
《Chinese Journal of Structural Chemistry》2018年第8期1233-1242,共10页任宏江 朱刚 李小军 何亚萍 
supported by the National Natural Science Foundation of China(No.21643014);the Special Natural Science Foundation of Science and Technology Bureau of Xi’an City Government(No.2016CXWL02 and SGH17H249)
The Ag clusters have been investigated widely theoretically and experimentally. In particular, it has recently shown that the neutral Ag8 clusters embedded in an argon matrix have a strong fluorescence signal. As we c...
关键词：6-MERCAPTOPURINE Ags cluster density functional theory bonding properties 
Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn's disease被引量：1
《World Journal of Gastroenterology》2018年第18期2036-2046,共11页Neera Gupta Robert H Lustig Cewin Chao Eric Vittinghoff Howard Andrews Cheng-Shiun Leu 
Supported by National Institutes of Health,No.DK077734(NG);Children’s Digestive Health and Nutrition Foundation(now known as North American Society for Pediatric Gastroenterology,Hepatology,and Nutrition Foundation)/Crohn’s and Colitis Foundation of America(now known as Crohn’s and Colitis Foundation)Award for New Investigators,No.CDHNF-06-002(NG);Crohn’s and Colitis Foundation of America(now known as Crohn’s and Colitis Foundation)Career Development Award,No.Award ID 1743(NG);University of California San Francisco Department of Pediatrics Pediatric Clinical Research Center Clinical Research Pilot Funding Award(NG);National Institutes of Health/National Center for Research Resources University of California San Francisco-Clinical and Translational Science Institute,No.UL1 RR024131
AIM To determine the distribution of anthropometric parameter(AP)-z-scores and characterize associations between medications/serum biomarkers and AP-z-scores in pediatric Crohn's disease(CD).METHODS CD patients [< chr...
关键词：Inflammatory BOWEL disease Azathioprine/6-mercaptopurine BIOLOGICS Nutrition 
The Promise of Pharmacogenomics in ReducingToxicity During Acute Lymphoblastic LeukemiaMaintenance Treatment被引量：6
《Genomics, Proteomics & Bioinformatics》2017年第2期82-93,共12页Shoshana Rudin Marcus Marable R. Stephanie Huang 
supports from the NIH/NIGMS (Grant Nos. U01GM61393 and K08GM089941);NIH/NCI (Grant No. R21 CA139278);Avon Foundation Research Grant, University of Chicago Cancer Center Support Grant (Grant No. P30 CA14599);Breast Cancer SPORE Career Development Award (Grant No. CA125183);the National Center for Advancing Translational Sciences of the NIH (Grant No. UL1RR024999) of the United States
Pediatric acute lymphoblastic leukemia(ALL) affects a substantial number of children every year and requires a long and rigorous course of chemotherapy treatments in three stages, with the longest phase, the maintenan...
关键词：Acute lymphoblastic leukemia 6-MERCAPTOPURINE METHOTREXATE PHARMACOGENOMICS Maintenance therapy 
Inclusion-Interaction Assembly Strategy for Constructing pH/Redox Responsive Micelles for Controlled Release of 6-Mercaptopurine
《Materials Sciences and Applications》2015年第7期605-616,共12页Mingyuan Tan Hua Zheng Xueqiong Zhang Zhiyan Yu Zhao Ye Liyan Shi Kaikai Ding 
An inclusion-interaction assembly strategy was used to construct novel pH/redox responsive core-shell micelles with hydrophobic drug as the core and hydrophilic polymer as the shell. At first, a dimer of hydrophobic d...
关键词：CHITOSAN CYCLODEXTRIN 6-MERCAPTOPURINE PH-SENSITIVE Redox-Responsive Controlled Release 
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