supported by the Medical Research Council (MRC)Grant (MR/V008935/1);supported by the National Natural Science Foundation of China (82304596);the Fundamental Research Funds for the Central Universities (3332022057);the CAMS Innovation Fund for Medical Sciences (2022-I2M-1-016);supported by the National Natural Science Foundation of China (81973383).
The Notch signaling pathway is evolutionarily conserved across metazoan species and plays key roles in many physiological processes.The Notch receptor is activated by two families of canonical ligands(Deltalike and Se...