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作品数：76被引量：263H指数：9
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相关领域：医药卫生农业科学更多>>
相关作者：秦立学王义徐慧马士涛赵文娟更多>>
相关机构：大连理工大学北方重工集团有限公司辽宁省交通高等专科学校佳木斯大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金江苏省自然科学基金更多>>
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Metformin promotes anti-tumor immunity in STK11 mutant NSCLC through AXIN1-dependent upregulation of multiple nucleotide metabolites
《Oncology Research》2024年第10期1637-1648,共12页ZHIGUO WANG KUNLIN LI CONGHUA LU MINGXIA FENG CAIYU LIN GUOFANG YIN DAN LUO WENYI LIU KAIYU JIN YUANYAO DOU DI WU JIE ZHENG KEJUN ZHANG LI LI XIANMING FAN 
People’s Hospital of Xuyong County-Southwest Medical University Science and Technology Strategic Cooperation Project(2023XYXNYD05);Guangdong Association of Clinical Trials(GACT)/Chinese Thoracic Oncology Group(CTONG)and Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer(2017B030314120);Natural Science Foundation of Chongqing Municipality(CSTB2023NSCQ-MSX0554).
Background:Metformin has pleiotropic effects beyond glucose reduction,including tumor inhibition and immune regulation.It enhanced the anti-tumor effects of programmed cell death protein 1(PD-1)inhibitors in serine/th...
关键词：METFORMIN Serine/threonine kinase 11(STK11) Lung cancer Axis inhibition protein 1(AXIN1) Nucleotide metabolites 
A proton-catalyzing prodrug for PDT and glycolysis inhibition-synergistic therapy of tumor in spatiotemporal dimensions
《Science China Chemistry》2024年第9期3162-3178,共17页Miao Li Xueying Sun Xiuqin Ma Yang Tan Xiaoyi Jin Yi Wang Fan Yang Qian Li Honglei Zhan Xiaojun Peng 
supported by the National Natural Science Foundation of China(22108024);the Dalian High-level Talent Innovation Support Program of China(2022RQ016);the Fundamental Research Funds for the Central Universities(DUT22LAB601)。
The reactive oxygen species(ROS)generation from photosensitizer in photodynamic therapy(PDT)is limited by tumor hypoxia.Even type-I photosensitizers,e.g.,sulfur-substituted Nile blue,still rely on oxygen as the main c...
关键词：photodynamic therapy PRODRUG glycolysis inhibition autophagy TUMOR synergistic therapy 
Chemical construction and anti-HCoV-OC43 evaluation of novel 10,12-disubstituted aloperine derivatives as dual cofactor inhibitors of TMPRSS2 and SR-B1
《Chinese Chemical Letters》2024年第5期201-206,共6页Yulong Shi Fenbei Chen Mengyuan Wu Xin Zhang Runze Meng Kun Wang Yan Wang Yuheng Mei Qionglu Duan Yinghong Li Rongmei Gao Yuhuan Li Hongbin Deng Jiandong Jiang Yanxiang Wang Danqing Song 
supported by the National Natural Science Foundation of China(No.81974494);CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-070).
Thirty-one new 10,12-disubstituted aloperine derivatives were subtly constructed through a selective oxidation on the 10-α-C-H induced by sulfonyl and a nucleophilic substitution with the stereoselectivity and scalab...
关键词：ALOPERINE SARS-CoV-2 TMPRSS2 SR-B1 Synthesis 
Subsequent strategies and underlying mechanism of acquired resistance to PD-1 axis inhibitors in advanced non-small cell lung cancer
《Chinese Medical Journal》2024年第7期880-882,共3页Huilan Wang Xinyu Cheng Fan Yang Lu Chen Anmei Zhang Liangzhi Zhong Haixia Long Bo Zhu Zhongyu Wang 
National Natural Science Foundation of China(No.82173097 to Z.W.);National Key Research&Development Program of China(Nos.2022YFC2505000 and 2022YFC2505002 to H.L.)
To the Editor:With the widespread application of immune checkpoint inhibitors(ICIs)in clinical practice,acquired resistance(AR)to programmed death-1(PD-1)/programmed death ligand 1(PD-L1)axis inhibitors in advanced no...
关键词：ROUTINE alterations resistance 
Novel insights in phosphodiesterase 4 subtype inhibition to target neuroinflammation and stimulate remyelination
《Neural Regeneration Research》2024年第3期493-494,共2页Melissa Schepers Tim Vanmierlo 
In neurodegenerative and classically demyelinating disorders such as multiple sclerosis(MS),spinal cord injury(SCI),stroke,and Charcot-Marie-Tooth disease,glial functioning is compromised and nervous tissue integrity ...
关键词：IMPAIRED INFLAMMATION Marie 
Analysis of a Strong-Inhibition Polyamine Drilling Fluid
《Fluid Dynamics & Materials Processing》2023年第9期2431-2447,共17页Yu Fan Jianhua Guo Xihui Hu Rui Wang Weiqiang Xu 
Drilling technologies based on oil-based drillingfluids and strong inhibitory saltwaterfluids are affected by draw-backs such as downhole accidents where sticking and wellbore instabilities occur.Existing polyamine dril...
关键词：High performance POLYAMINE strong inhibition adhesion sticking wellbore stability 
Carrier-free nanodrugs for stemness inhibition-enhanced photodynamic therapy
《Aggregate》2023年第3期84-93,共10页Yuwei Liu Kaiqi Long Tianyi Wang Weirong Kang Weiping Wang 
Research Grants Council of Hong Kong,Grant/Award Number:27115220;Ming Wai Lau Centre for Reparative Medicine Associate Member Program。
Cancer stem cell(CSC)has been considered a key driver of tumor growth,recurrence,and metastasis due to its self-renewal and tumor initiation capacities called stemness.Stemness is also responsible for the high resista...
关键词：cancer stemness NANOMEDICINE Notch pathway photodynamic therapy SELF-ASSEMBLY 
Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation被引量：1
《Acta Pharmacologica Sinica》2023年第5期1051-1065,共15页Hui-fang Zhang Hui-ming Liu Jia-yi Xiang Xing-cheng Zhou Dan Wang Rong-yu Chen Wan-lin Tan Lu-qun Liang Ling-ling Liu Ming-jun Shi Fan Zhang Ying Xiao Yu-xia Zhou Tian Zhang Lei Tang Bing Guo Yuan-yuan Wang 
supported by the National Natural Science Foundation of China(82060141,81960141);Merit-based Funding for High-level Talent Innovation and Entrepreneurship in Guizhou Province[(2021)02];Science and Technology Top Talent Project of General Higher Education Institutions in Guizhou Province(Qianjiaohe KY[2021]032).
Previous studies have shown mitochondrial dysfunction in various acute kidney injuries and chronic kidney diseases.Lipoic acid exerts potent effects on oxidant stress and modulation of mitochondrial function in damage...
关键词：diabetic kidney disease alpha lipoamide mitochondria RXRα CDX2 tubulointerstitial fibrosis 
DSCR9/miR-21-5p axis inhibits pancreatic cancer proliferation and resistance to gemcitabine via BTG2 signaling被引量：2
《Acta Biochimica et Biophysica Sinica》2022年第12期1775-1788,共14页Hui Huang Xia Li Xianlin Zhang Zhiqiang Li Duo Han Wenzhe Gao Ling Liu Cheng Peng Hongwei Zhu Xiao Yu 
supported by the grant from the National Natural Science Foundation of China(No.81873589).
The outcome of pancreatic adenocarcinoma(PAAD)patients is poor,given resistance to gemcitabine.Long noncoding RNA(lncRNA)has been implicated in the carcinogenesis of pancreatic cancer;however,its function and mechanis...
关键词：pancreatic cancer lncRNA DSCR9 miR-21-5p BTG2 PROLIFERATION gemcitabine resistance 
Emerging potential of ubiquitin-specific proteases and ubiquitinspecific proteases inhibitors in breast cancer treatment被引量：1
《World Journal of Clinical Cases》2022年第32期11690-11701,共12页Mei-Ling Huang Guang-Tai Shen Nan-Lin Li 
Supported by the National Natural Science Foundation of China,No.81472598;Project of Xijing Hospital,No.XJZT18MJ30.
Breast cancer is the most frequently diagnosed cancer in women,accounting for 30%of new diagnosing female cancers.Emerging evidence suggests that ubiquitin and ubiquitination played a role in a number of breast cancer...
关键词：Ubiquitin-specific proteases USPs inhibitors Breast cancer Review 
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