云南高校图书馆联盟文献共享服务平台- PEPTIDE

PEPTIDE: 作品数：1062被引量：2043H指数：15; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：杨松成张学敏张滨魏开华王红霞更多>>; 相关机构：北京大学福建医科大学复旦大学军事医学科学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Trinuclear gold-catalyzed site-selective alkylation of peptides: 《Science China Chemistry》2025年第1期249-256,共8页Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan Yong Liang Weipeng Li Chengjian Zhu Jie Han Jin Xie; the National Key Research and Development Program of China(2021YFC2101900,2022YFA1503200);the National Natural Science Foundation of China(22122103,22101130,22001117,22471121,22271144);the Fundamental Research Funds for the Central Universities(020514380327);the open project of state key laboratory of natural medicines(SKLNMKF202401)for financial support。; Selective modification of peptides has always been a challenging issue.The selective alkylation of peptides can alter the biological activity and physical properties of molecules,and it has gained significant research...; 关键词：gold catalysis PEPTIDE ALKYLATION C-C coupling RADICAL

LADA strategy for the synthesis of unnatural amino acids and direct modifications of peptides: 《Science China Chemistry》2023年第6期1788-1794,共7页Jun-Liang Zhou Yun-Qi Liu Zhan-Kui Sun; supported by the Shanghai Jiao Tong University(WF220417003 to Z.S.)。; Unnatural amino acids(UAAs)are important building blocks in organic synthesis and drug discovery.They are also frequently integrated into peptides or proteins for biological studies.However,the direct and simplified s...; 关键词：unnatural amino acids peptide modifications DESULFURIZATION CYSTEINE radical addition

Host defense peptide-mimicking peptide polymer-based antibacterial hydrogel enables efficient healing of MRSA-infected wounds被引量：2: 《Science China Chemistry》2023年第6期1824-1833,共10页Zhongqian Qiao Wenjing Zhang Yueming Wu Weinan Jiang Ning Shao Jiayang Xie Guixue Xia Qimeng Chen Zhefeng Liu Jingcheng Zou Jiawei Gu Shifang Luan Haodong Lin Runhui Liu; supported by the National Natural Science Foundation of China(22075078,52203162);the Program of Shanghai Academic/Technology Research Leader(20XD1421400);Shanghai Sailing Program(21YF1409100);China National Postdoctoral Program for Innovative Talents(BX20220108);the China Postdoctoral Science Foundation(2021M701198);the Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry(Changchun Institute of Applied Chemistry,Chinese Academy of Sciences);the Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism(2021Sci&Tech 03-28,Shanghai Municipal Education Commission)。; Wound infections are a compelling health issue caused by the invasion and proliferation of pathogens in wound sites.Antibioticloaded hydrogels are widely used to achieve anti-infectious wound healing.However,due to th...; 关键词：peptide polymer wound healing MRSA DRUG-RESISTANCE host defense peptide

Hierarchical metal-peptide assemblies with chirality-encoded spiral architecture and catalytic activity: 《Science China Chemistry》2023年第1期228-241,共14页Jiayu Liu Jiaxing Zhang Liwei Zhang Yuefei Wang Hao Wei Yuhe Shen Jiwei Min Xi Rong Wei Qi Rongxin Su Zhimin He; supported by the National Natural Science Foundation of China(21621004,51773149,22078239);Tianjin Development Program for Innovation and Entrepreneurship(2018);the State Key Laboratory of Chemical Engineering(SKL-Ch E-20Z04,SKLCh E-21T03)。; We report the coordination assembly of the ferrocene-diphenylalanine(Fc-FF)with divalent copper ions(Cu^(2+))into metalpeptide assemblies(MPAs)with hierarchical spiral architectures.The MPA particles are composed of h...; 关键词：PEPTIDE metal coordination spiral particles CHIRALITY CATALYSIS

Preorganization boosts the artificial esterase activity of a self-assembling peptide被引量：1: 《Science China Chemistry》2021年第9期1554-1559,共6页Yaoxia Chen Wenwen Zhang Yinghao Ding Chunhui Liang Yang Shi Zhi-Wen Hu Ling Wang Zhimou Yang; supported by the National Science Fund for Distinguished Young Scholars(31825012);the National Natural Science Foundation of China(21875116,31961143004,81921004);the National Key Research and Development Program of China(2017YFC1103502,2018YFC1003401);the China Postdoctoral Science Foundation(2020M680856)。; The creation of artificial enzymes to mimic natural enzymes remains a great challenge owing to the complexity of the structural arrangement of the essential amino acids in catalytic centers.In this study,we used the p...; 关键词：enzyme-instructed self-assembly PREORGANIZATION artificial esterase catalytic activities peptide folding

Enabling AIEgens close assembly in tumor-overexpressed protein cluster for boosted image-guided cancer surgery: 《Science China Chemistry》2020年第11期1694-1702,共9页Junxiao Gao Jun Li Daohe Wei Han Yang Yue Duan Yue Zhang Xiaoqun Gong Hanjie Wang Dan Ding Xiaoli Wu Jin Chang; This work was supported by the Tianjin Technical Expert Project(19JCTPJC41200);the National Natural Science Foundation of China(51873150,31770974);the National Key Research and Development Program of China(Intergovernmental Cooperation Project,2017YFE0132200).; Development of efficient fluorescent probes that can realize precise fluorescence image-guided cancer surgery(FIGCS)with extremely high tumor-to-normal tissue(T/NT)ratio is urgently desirable.Herein,we report the desi...; 关键词：aggregation-induced emission luminogen fluorescent probe self-assembling peptide fluorescence image-guided cancer surgery tumor-to-normal tissue ratio

Freezing the kinase signaling of breast cancer with transformable peptide nanoparticles: 《Science China Chemistry》2020年第8期1021-1022,共2页Di-Wei Zheng Xian-Zheng Zhang; Protein kinases have been recognized as dominant regulators of all aspects of tumor progression,including tumorigenesis,proliferation,invasion,and metastasis[1].During the activation of protein kinases,the binding of ...; 关键词：INVASION METASTASIS BREAST

Shape linear peptides into rigid rings: a sp^3 C–H arylation approach to cyclophane-braced peptide macrocycles: 《Science China Chemistry》2018年第12期1477-1478,共2页Yuankun Dao Suwei Dong; Peptide-based therapeutics have attracted increasing attention due to their unique properties in comparison to small molecule drugs and recombinant biologics [1].With moderate size and suitable surface area,peptides p...; 关键词：Shape linear PEPTIDES RIGID RINGS PEPTIDE macrocycles

Topology: a unique dimension in protein engineering被引量：3: 《Science China Chemistry》2018年第1期3-16,共14页Lianjie Xu Wen-Bin Zhang; supported by the National High Technology Research and Development Program of China (2015AA020941);the National Natural Science Foundation of China (21474003, 91427304);"1000 Plan (Youth)"; Controlling protein topology has been a long standing challenge to go beyond their linear configuration defined by the translation mechanism of cellular machinery. In this mini-review, we focus on the topological dive...; 关键词：protein topology protein engineering CATENANE ROTAXANE KNOT lasso peptide

Effects of chain length and hydrophobicity/charge ratio of AMP on its antimicrobial activity: 《Science China Chemistry》2017年第3期385-395,共11页Qiuhong Yu Zhengxi Zhang Jianbo Sun Yuqiong Xia Quan Du Dehai Liang; supported by the National Natural Science Foundation of China(21574002,21174007);the Beijing Natural Science Foundation(5132015);the Nantong Jianghai Talent Program; Using two series of de novo designed antimicrobial peptides,we studied the effects of peptide length and hydrophobicity/charge(H/C) ratio on the antimicrobial activities.For these peptides,a correlation was establishe...; 关键词：antimicrobial peptides peptide length hydrophobicity/charge ratio

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